Coverage Rate of ADME Genes: Application to CYP2C8, CYP2D6 and CYP3A Genes for Personalized Chloroquine Treatment Against Coronavirus

Abstract

Background: The latest studies have shown the effectiveness of Chloroquine against Coronavirus. However, since the tolerance and effectiveness of statistical data must be taken into account before proposing treatment to a patient, these promising results are often lacking.Since the CYP2C8, CYP2D6 and CYP3A Absorption, Distribution, Metabolism and Elimination (ADME) genes are involved in the drug response of Chloroquine, we are interested in studying the variations of these genes.Methods: The purpose of this study is to make a comparison between the various current genotyping and enrichment platforms, to know which of them allows the best coverage. Conclusions: This will allow us to carry out genome-wide association studies (GWAS) with the aim of finding new therapeutic targets against Coronavirus using Chloroquine.