Covered Stent Septal Ablation for Hypertrophic Obstruction Cardiomyopathy

Anzuini, Angelo; Uretsky, Barry F.

doi:10.1161/01.cir.0000111127.49988.79

Cited by 62 publications

(10 citation statements)

References 4 publications

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“…Oxidative stress and inflammation are emerging unifying patho-physiological mechanisms leading to cardiovascular disease [1]. Various cellular detoxification systems exist that protect against both endogenous and environmental toxic substances.…”

Section: Introductionmentioning

confidence: 99%

Glutathione S-Transferase Gene Polymorphism as a Susceptibility Factor for Acute Myocardial Infarction and Smoking in the North Indian Population

et al. 2011

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Objectives: Glutathione S-transferase (GST) plays a key role in the detoxification of xenobiotic atherogens generated by smoking. We investigated whether functional GST gene polymorphism might be associated with acute myocardial infarction (AMI) and smoking. No such investigation has previously been conducted among North Indians. Methods: 230 patients with AMI and 300 healthy controls of North Indian ethnicity were enrolled in the study. GSTM1/T1/P1 gene polymorphisms were examined using restriction fragment length polymorphism. Results: When GST polymorphism was analyzed in patients with AMI, GSTM1 null genotype frequencies were 0.24 and 0.21 among cases with coronary artery disease and controls, respectively. The respective GSTT1 null genotype frequencies were 0.10 and 0.20 (p = 0.001). GSTP1 variant Val/Val allele frequencies were 0.02 and 0.07 with p = 0.03. After risk factor adjustment, only GSTP1Val/Val was found to be protective against disease. Considering the effect of GST (T1, M1, and P1) gene polymorphism on smoking, subjects were further divided into smokers and nonsmokers. However, GSTT1 null as well as GSTP Val/Val genotypes were protective only in nonsmokers (p = 0.01 and p = 0.04). Conclusions: A significant protective effect of GSTT1 null and GSTP1 Val genotype against disease was observed in patients with AMI although protection was limited to nonsmokers.

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Section: Introductionmentioning

confidence: 99%

Glutathione S-Transferase Gene Polymorphism as a Susceptibility Factor for Acute Myocardial Infarction and Smoking in the North Indian Population

et al. 2011

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“…Traditional biomarkers appear insufficient to predict CVD risk and novel non-traditional biomarkers are being scrutinized to better predict adverse CVD events [2,3,4,5,6]. These novel markers are detectable even among patients without evidence of abnormalities in traditional biomarkers [6, 7].…”

Section: Introductionmentioning

confidence: 99%

“…Markers of inflammation have received attention as predictors of CVD outcome in the general population and patients with CKD [2,13,14,15]. However, markers of endothelial activation have not been explored in anemic ND-CKD patients.…”

Section: Introductionmentioning

confidence: 99%

Endothelial Activation Markers in Anemic Non-Dialysis Chronic Kidney Disease Patients

et al. 2008

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Background/Aims: Anemia in chronic kidney disease is an independent predictor of cardiovascular disease (CVD). We explored the relationship between anemia and markers of inflammation and endothelial activation in non-dialysis chronic kidney disease (ND-CKD) patients to understand this mechanism. Methods: Cross-sectional analysis was performed on 30 adult ND-CKD patients for markers of inflammation and endothelial activation using a multiplexed immunoassay. Data were analyzed according to the anemic status defined by the modified World Health Organization criteria. Results: Seventeen patients were classified as anemic. Baseline characteristics by anemic status were similar except that anemic patients were older (p = 0.006), had lower estimated glomerular filtration rate (eGFR; p = 0.01) and higher prevalence of CVD (p = 0.02). Compared to non-anemic patients, log-transformed values of fibrinogen (p = 0.012); von Willebrand factor (vWF, p = 0.008), vascular cell adhesion molecule-1 (VCAM-1, p = 0.025) and C-reactive protein (p = 0.043) were elevated in anemic patients. Serum ferritin (p = 0.93) and serum albumin (p = 0.06) were not different. Age and eGFR-adjusted logistic regression analysis showed that anemic patients had increased odds for a composite of higher median values of fibrinogen, vWF and VCAM-1 (p = 0.01, odds ratio 8.1, 95% CI 1.08–111.0). Conclusion: We report the association of anemia with elevated markers of endothelial activation in ND-CKD patients. Longitudinal studies are needed to confirm our findings.

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“…7 In 2004, a covered stent was used due to the inability to cannulate the first septal artery; collateralisation from the right coronary artery led to symptom recurrence after an undisclosed period of time. 8 Finally, in 2006, a woman with coronary artery disease and an alcohol septal ablation 6 months prior had a covered stent placed after symptom recurrence due to 70% stenosis of the left anterior descending and D1. Twelve months after placement, her gradient remained low and she was asymptomatic.…”

Section: Discussionmentioning

confidence: 99%

Effective treatment of hypertrophic cardiomyopathy with left ventricular outflow tract obstruction using a covered stent

2022

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A woman in her 60s presented with progressive exertional dyspnoea, exertional chest pressure and exertional dizziness. Echocardiogram identified a 156 mm Hg left ventricular outflow tract gradient with provocation, indicating hypertrophic cardiomyopathy with left ventricular outflow obstruction—confirmed with MRI and angiogram. An alcohol septal ablation was planned but due to communication of the second septal perforator with the right ventricle and a wire-induced mid-left anterior descending artery dissection, alcohol septal ablation was not performed. Instead, a covered stent was placed in the mid-left anterior descending artery covering the origins of the third and fourth septal perforators. The left ventricular outflow tract gradient decreased from 90 to 30 mm Hg with provocation and her symptoms improved. Follow-up showed a left ventricular outflow tract gradient of 35 mm Hg with provocation and decreased symptoms.

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Covered Stent Septal Ablation for Hypertrophic Obstruction Cardiomyopathy

Cited by 62 publications

References 4 publications

Glutathione S-Transferase Gene Polymorphism as a Susceptibility Factor for Acute Myocardial Infarction and Smoking in the North Indian Population

Glutathione S-Transferase Gene Polymorphism as a Susceptibility Factor for Acute Myocardial Infarction and Smoking in the North Indian Population

Endothelial Activation Markers in Anemic Non-Dialysis Chronic Kidney Disease Patients

Effective treatment of hypertrophic cardiomyopathy with left ventricular outflow tract obstruction using a covered stent

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