2021
DOI: 10.3390/jcm11010013
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Covert Brain Infarcts in Patients with Philadelphia Chromosome-Negative Myeloproliferative Disorders

Abstract: Backgrounds and Purpose. Philadelphia chromosome-negative myeloproliferative disorders (Ph-negative MPD) are a rare group of hematological diseases, including three distinct pathologies: essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF). They most often manifest with thrombotic complications, including cerebrovascular events. Covert brain infarcts (CBIs) are defin ed as predominantly small ischemic cerebral lesions that are detected using magnetic resonance imaging (MRI) i… Show more

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Cited by 4 publications
(1 citation statement)
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“…Mayerhofer et al [ 83 ] highlighted that young individuals who experience episodes of stroke display a three-times elevated prevalence of clonal hematopoiesis of indeterminate potential mutations and several suffer from MPNs and eventually need of cytoreduction treatment. Furthermore, they defined that these patients express a higher burden of atherosclerosis and an elevated carotid intima media thickness, reinforcing that there is pronounced endothelial dysfunction in MPNs[ 83 , 84 ]. It is well known that dyslipidemia aggravates atherogenesis and is associated with inflammation, oxidative stress, cytokines, and other molecular messengers to promote atherosclerosis, including in subjects with MPNs[ 85 - 87 ].…”
Section: Molecular Mechanisms Common In Dyslipidemia Mets and Mpnsmentioning
confidence: 99%
“…Mayerhofer et al [ 83 ] highlighted that young individuals who experience episodes of stroke display a three-times elevated prevalence of clonal hematopoiesis of indeterminate potential mutations and several suffer from MPNs and eventually need of cytoreduction treatment. Furthermore, they defined that these patients express a higher burden of atherosclerosis and an elevated carotid intima media thickness, reinforcing that there is pronounced endothelial dysfunction in MPNs[ 83 , 84 ]. It is well known that dyslipidemia aggravates atherogenesis and is associated with inflammation, oxidative stress, cytokines, and other molecular messengers to promote atherosclerosis, including in subjects with MPNs[ 85 - 87 ].…”
Section: Molecular Mechanisms Common In Dyslipidemia Mets and Mpnsmentioning
confidence: 99%