COVID-19: A state of art on immunological responses, mutations, and treatment modalities in riposte

Gong, Xiaolong; Khan, Amber; Wani, Mohmmad Younus; Ahmad, Aijaz; Dusé, Adriano

doi:10.1016/j.jiph.2022.12.019

Cited by 9 publications

(9 citation statements)

References 150 publications

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“…In 2020, the average prevalence of anxiety and depression among college students in the early stages of the COVID-19 pandemic was approximately 24.79% and 28.5%. However, COVID-19 has undergone multiple mutations to become more susceptible, leading to changes in external and internal conditions [19]. In 2021, the incidence of depression (62.91%) and anxiety (15.43%) in college students was reported [20].…”

Section: Discussionmentioning

confidence: 99%

The mental health of college students: After the reduction of COVID-19 pandemic restrictions

He,

Zhu,

et al. 2023

Preprint

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Among adolescents and young adults, self-reported baseline psychological distress was quite high during the COVID-19 pandemic. As a vulnerable group, college students suffer from serious psychological problems such as anxiety and depression during the COVID-19 pandemic. Despite the fact that COVID-19 no longer constitutes a public health emergency of international concern and the reduction of COVID-19 pandemic restrictions in March 2023, the change of college students' mental health remains unclear. In March and June 2023, college students in Kunming, China, were investigated by the Self-Rating Anxiety Scale, Self-Rating Depression Scale, and Pittsburgh Sleep Quality Index. After the COVID-19 pandemic restrictions were reduced, the results of the scale indicated anxiety (-0.6%, 21.6%-21%), mild anxiety (+ 0.5%, 16.50%-17.0%), moderate anxiety (-0.7%, 3.94%-3.2%), and severe anxiety (-0.4%, 1.2%-0.8%). Depression (-8.1%, 37.2%-29.1%), mild depression (-5.2%, 19.4%-14.2%), moderate depression (-2.2%, 16.7%-14.5%), or severe depression (-0.7%, 1.1%-0.3%) among college students. Good sleep quality (0%, 72.3%-72.3%) and poor sleep quality (0%, 27.7%-27.7%); anxiety or depression (-6.5%, 39.7%-33.2%) among college students. The incidence of anxiety and depression in college students was reduced, after the reduction of COVID-19 pandemic restrictions.

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Section: Discussionmentioning

confidence: 99%

The mental health of college students: After the reduction of COVID-19 pandemic restrictions

He,

Zhu,

et al. 2023

Preprint

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“…Prompted by the recent global COVID-19 pandemic, nanomedicine-driven vaccines emerged as pivotal agents in preventive and therapeutic interventions 1 . However, clinical studies have shown that immune responses to these vaccines differ among individuals 2,3 .…”

Section: Introductionmentioning

confidence: 99%

Deep, unbiased and quantitative mass spectrometry-based plasma proteome analysis of individual responses to mRNA COVID-19 vaccine

Huang,

Campos,

Wang

et al. 2024

Preprint

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Global campaign against COVID-19 have vaccinated a significant portion of the world population in recent years. Combating the COVID-19 pandemic with mRNA vaccines played a pivotal role in the global immunization effort. However, individual responses to a vaccine are diverse and lead to varying vaccination efficacy. Despite significant progress, a complete understanding of the molecular mechanisms driving the individual immune response to the COVID-19 vaccine remains elusive. To address this gap, we combined a novel nanoparticle-based proteomic workflow with tandem mass tag (TMT) labeling, to quantitatively assess the proteomic changes in a cohort of 12 volunteers following two doses of the Pfizer-BioNTech mRNA COVID-19 vaccine. This optimized protocol seamlessly integrates comprehensive proteome analysis with enhanced throughput by leveraging the enrichment of low-abundant plasma proteins by engineered nanoparticles. Our data demonstrate the ability of this nanoparticle-based workflow to quantify over 3,000 proteins from 48 human plasma samples, providing the deepest view into COVID-19 vaccine-related plasma proteome study. We identified 69 proteins exhibiting a boosted response to the vaccine after the second dose. Additionally, 74 proteins were differentially regulated between seven volunteers, who contracted COVID-19 despite receiving two doses of the vaccine, and the ones who did not contract COVID-19. These findings offer valuable insights into individual variability in response to vaccination, demonstrating the potential of personalized medicine approaches in vaccine development.

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“… 18 , 19 Since the SARS-CoV-2 virus is constantly evolving, resulting in different subtypes that may have different symptoms, it is necessary to constantly update knowledge about the COVID-19 disease, including possible new symptoms and to be particularly vigilant in the evaluation of patients during and after the disease. 20 , 21 Ophthalmic pathologies resulting from SARS-CoV2 virus may affect all structures of the eye and manifest as ophthalmological symptoms due to the pathological effect of the virus on distant structures and tissues.…”

Section: Introductionmentioning

confidence: 99%

The Review of Ophthalmic Symptoms in COVID-19

Stawowski,

Konopińska,

Stawowski

et al. 2024

OPTH

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The COVID-19 pandemic caused by SARS-CoV-2 had a significant impact on the health of the global human population, affecting almost every human organ, including the organ of vision. Research focus on understanding the pathophysiology, identifying symptoms and complications of the disease. Eye-related pathologies are important foci of research due to the potential for direct impact of the virus. Ophthalmologists around the world are reporting various symptoms of eye infections and ocular pathologies associated with SARS-CoV-2. The review of ophthalmic symptoms was conducted to help physicians of various specialties recognize possible ophthalmic manifestations of this viral disease. A literature review was conducted from January 2020 to July 2023 in the PubMed, MEDLINE, Science Direct, Scopus, Scielo and Google Scholar databases. The review of the literature showed that conjunctivitis is the most common ophthalmic symptom observed during the course of COVID-19 and can occur at any stage of the disease. Changes in the eye may result from the direct effect of the virus, immune response, prothrombotic states, comorbidities, and medications used. Symptoms related to the organ of vision can be divided into: changes affecting the protective apparatus of the eye, the anterior eye segment, the posterior eye segment, neuro-ophthalmic, and orbital changes. Ocular symptoms may suggest COVID-19 infection or appear several weeks after recovery. Following COVID-19 vaccinations, a diverse range of ophthalmic symptoms was observed in various locations and at different times, mirroring the ocular symptoms experienced throughout the course of the COVID-19 illness. It is important for physicians of all specialties to be aware of possible potential connections between eye diseases and SARS-CoV-2, in order to effectively diagnose and treat patients.

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COVID-19: A state of art on immunological responses, mutations, and treatment modalities in riposte

Cited by 9 publications

References 150 publications

The mental health of college students: After the reduction of COVID-19 pandemic restrictions

The mental health of college students: After the reduction of COVID-19 pandemic restrictions

Deep, unbiased and quantitative mass spectrometry-based plasma proteome analysis of individual responses to mRNA COVID-19 vaccine

The Review of Ophthalmic Symptoms in COVID-19

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