COVID-19 adaptive evolution during the pandemic – Implications of new SARS-CoV-2 variants on public health policies

Oosterhout, Cock van; Stephenson, Jessica F.; Weimer, Bart C.; Ly, Hinh; Hall, Neil

doi:10.1080/21505594.2021.1960109

Cited by 7 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, a high vaccination rate indirectly decreases the risk of the emergence of new dangerous variant strains of the virus by offering it a reduced population, crippling its evolutionary potential (cf. Van Oosterhout et al , 2021 : 2013), which in turn benefits the populations of other nations where these variants could spread.…”

Section: A Virtuous Ruler and Mandatory Covid-19 Vaccinationsmentioning

confidence: 99%

COVID-19 Vaccines and the Virtues

Boyneburgk

Bellazzi

2022

Public Health Ethics

View full text Add to dashboard Cite

From a moral point of view, what arguments are there for and against seeking COVID-19 vaccination? Can it be morally permissible to require (parts of) a population to receive a vaccine? The present paper adopts a perspective of virtue ethics and argues both that it is morally right for an individual virtuous moral agent to seek COVID-19 vaccination and for a virtuous ruler to impose mandatory vaccinations on her population. We begin by first presenting virtue ethics and the current vaccine controversy. Second, we examine whether a virtuous individual should get vaccinated. Third, we consider whether, from a moral point of view, it is right for a ruler to impose mandatory vaccinations on her citizens. Fourth, we answer some objections to our argument. Finally, we conclude that virtue ethical considerations warrant both the individual choice of getting vaccinated and mandatory vaccinations against COVID-19.

show abstract

Section: A Virtuous Ruler and Mandatory Covid-19 Vaccinationsmentioning

confidence: 99%

COVID-19 Vaccines and the Virtues

Boyneburgk

Bellazzi

2022

Public Health Ethics

View full text Add to dashboard Cite

show abstract

“…It should be mentioned that the current pandemic created by the SARS-CoV-2 is a result of adaptive evolution of the virus to human hosts (Rochman et al, 2021 ). Further adaptation of the virus to better suit the environment, in this case humans, is the delta variant of the virus (van Oosterhout et al, 2021 ). As the mechanisms of adaptive evolution are deciphered, the predictability of such evolution can be improved to better control emerging diseases.…”

Section: Adaptive Evolution Application In Research and Industrymentioning

confidence: 99%

Microbial adaptive evolution

Shi

Feng

Broach

2021

Journal of Industrial Microbiology and Biotechnology

View full text Add to dashboard Cite

Bacterial species can adapt to significant changes in their environment by mutation followed by selection, a phenomenon known as adaptive evolution. With the development of bioinformatics and genetic engineering, research on adaptive evolution has progressed rapidly, as have applications of the process. In this review, we summarize various mechanisms of bacterial adaptive evolution, the technologies used for studying it and successful applications of the method in research and industry. We particularly highlight the contributions of Dr. L.O. Ingram. Microbial adaptive evolution has significant impact on our society not only from its industrial applications but also in the evolution, emergence and control of various pathogens.

show abstract

“…Rapid and extensive transmission worldwide has provided more chances for SARS-CoV-2 genome to accumulate mutations. After frequent mutations for around two years, SARS-CoV-2 has diverged greatly and formed many different lineages [23] , [24] . While monitoring mutations in specific viral proteins facilitates the development of effective vaccines and antiviral drugs [25] , [26] , understanding the evolution trend of SARS-CoV-2 genome could help foresee difficulties in controlling spread of the virus [27] , [28] .…”

Section: Introductionmentioning

confidence: 99%

Human SARS-CoV-2 has evolved to increase U content and reduce genome size

Wang

Chen

Liu

et al. 2022

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Infections caused by SARS-CoV-2 have brought great harm to human health. After transmission for over two years, SARS-CoV-2 has diverged greatly and formed dozens of different lineages. Understanding the trend of its genome evolution could help foresee difficulties in controlling transmission of the virus. In this study, we conducted an extensive monthly survey and in-depth analysis on variations of nucleotide, amino acid and codon numbers in 311,260 virus samples collected till January 2022. The results demonstrate that the evolution of SARS-CoV-2 is toward increasing U-content and reducing genome-size. C, G and A to U mutations have all contributed to this U-content increase. Mutations of C, G and A at codon position 1, 2 or 3 have no significant difference in most SARS-CoV-2 lineages. Current viruses are more cryptic and more efficient in replication, and are thus less virulent yet more infectious. Delta and Omicron variants have high mutability over other lineages, bringing new threat to human health. This trend of genome evolution may provide a clue for tracing the origin of SARS-CoV-2, because ancestral viruses should have lower U-content and probably bigger genome-size.

show abstract

COVID-19 adaptive evolution during the pandemic – Implications of new SARS-CoV-2 variants on public health policies

Cited by 7 publications

References 13 publications

COVID-19 Vaccines and the Virtues

COVID-19 Vaccines and the Virtues

Microbial adaptive evolution

Human SARS-CoV-2 has evolved to increase U content and reduce genome size

Contact Info

Product

Resources

About