COVID-19 after hematopoietic stem cell transplantation: report of two children

Zamperlini–Netto, Gabriele; Fernandes, Juliana Folloni; Garcia, José Nivaldo; Ribeiro, Andreza Alice Feitoza; Camargo, Luís Fernando Aranha; Terra, Celso de Moraes; Hamerschlak, Nelson

doi:10.1038/s41409-020-01041-8

Cited by 22 publications

(38 citation statements)

References 14 publications

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“…In 29 studies ( n = 177 patients), 8,11–14,16–39 there was a mention of the type of test used to detect SARS‐CoV‐2. Among the 177 patients in these studies, PCR‐based tests were used to establish the diagnosis in 142 (one was also positive on CBNAAT) and antibody‐based tests in 23 (the type of test used was not mentioned for 12 patients in the study by Montoya et al 18 …”

Section: Resultsmentioning

confidence: 99%

“…In 196 patients (31 studies), 5,10–39 there was a mention about the type of malignancy, and 120 (53%) had hematological malignancies, and 76 (47%) had solid tumors. In studies that reported remission status (18 studies), 23 patients out of 47 were in remission from the underlying malignancy 10,11,14,20–26,29–37 (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Among 24 studies including 102 patients 5,10,13–17,20–25,27–35,37 for whom information was available on the phase of chemotherapy/hematopoietic stem cell transplant (HSCT) status, 34 were on the intensive phase of chemotherapy, 13 were on low‐dose chemotherapy, six had completed treatment, and 17 post HSCT (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐six studies ( n = 184 patients) reported about clinical symptoms 5,10–14,16–18,20–28,30–36,38 . Amongst the 184 patients included in these studies, fever was the commonest symptom in 77 (41.4%), followed by cough (12.3%).…”

Section: Resultsmentioning

confidence: 99%

“…Gastrointestinal symptoms were present in 17, and skin involvement was mentioned for three patients. In 30 studies ( n = 209 patients), 5,8,10–18,20–38 the severity of the symptoms was reported. Sixty‐three patients had no symptoms, 38 had mild symptoms, nine had moderate symptoms, and 20 (9.6%) had severe symptoms.…”

Section: Resultsmentioning

confidence: 99%

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Clinical presentations and outcomes of children with cancer and COVID‐19: A systematic review

Meena

Gupta

Tanwar

et al. 2021

Pediatric Blood & Cancer

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Information regarding the novel coronavirus disease (COVID‐19) in pediatric oncology is limited. We conducted a systematic review of the available published literature on children with cancer affected by COVID‐19. The last date of the study search was October 20, 2020, and 33 studies comprising 226 children were included for the final analysis. Data were extracted in a predefined data collection form, and the variables were extracted and analyzed. Patients with hematological malignancies were more in number. Males and children on intensive treatment were more frequently affected. Fever was the commonest symptom. The disease was asymptomatic/mild in 48% and severe in 9.6%. Consolidation, peribronchial cuffing, and consolidation with ground glass opacities were the common imaging findings. Hydroxychloroquine was the most frequently used drug for COVID‐19. About 10% of children required intensive care, and about 32% had oxygen requirements. The percentage of children who died due to COVID‐19 was 4.9%. The severity, morbidity, and mortality of COVID‐19 in pediatric oncology were more compared to the general pediatric population. This information can help in risk stratification for the management of COVID‐19.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Clinical presentations and outcomes of children with cancer and COVID‐19: A systematic review

Meena

Gupta

Tanwar

et al. 2021

Pediatric Blood & Cancer

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COVID‐19 and pediatric pulmonology: Feedback from an expert center after the first year of the pandemic

Corvol

Prévost

Aubertin

et al. 2022

Pediatric Pulmonology

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The coronavirus disease 2019 (COVID‐19) outbreak has evolved with different waves corresponding to subsequent severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) mutations. While the most severe cases have been observed in the elderly and in individuals with underlying comorbidities, severe pediatric and young adult cases have been observed, as well as post‐infectious inflammatory syndromes and persistent symptoms leading to long‐COVID. This manuscript describes the experience of a pediatric respiratory unit during the first year of the pandemic and reviews the corresponding literature with a special emphasis on children and young people with underlying conditions, such as immunosuppression, sickle cell disease, and cystic fibrosis.

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