COVID-19 and Aging-Related Genome (Chromosome) Instability in the Brain: Another Possible Time-Bomb of SARS-CoV-2 Infection

Iourov, Ivan Y.; Vorsanova, Svetlana G.

doi:10.3389/fnagi.2022.786264

Cited by 6 publications

(5 citation statements)

References 29 publications

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“…It is widely recognized that COVID-19 infection poses numerous problems for the human genome, particularly in terms of genomic stability (Iourov & Vorsanova, 2022). One aspect of genomic instability is the issue of telomere regulation (telomere dysregulation), which can lead to cell death (Sepe et al, 2022).…”

Section: Genomic Instabilitymentioning

confidence: 99%

Mapping the Genomic Impact of the COVID-19 Virus

Ikawaty,

Efendi Marzuki HY,

Baharuddin

2024

Preprint

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The COVID-19 pandemic caused by the RNA virus SARS-CoV-2, has had a significant impact not only on bodily metabolism but also at the genomic level. This study utilizes a bibliometric approach to map and identify the relationship between COVID-19 and DNA damage, genomic instability, and cell cycle deregulation. The research began with the development of in-depth research questions and conducted two rounds of literature search in the Scopus database with stringent filters to ensure relevance and accuracy. From an initial 1098 documents, 576 relevant documents were selected for further analysis. The collected data was then visualized using bibliometric methods, enabling the identification of important patterns, trends, and relationships among the research variables. Key findings indicate that DNA damage, which can induce apoptosis, is the worst impact of the infection on cells. Term frequency analysis and science mapping revealed a close relationship between "DNA damage" and "apoptosis". Furthermore, discussions on genomic instability highlight telomere regulation issues, while cell cycle deregulation during virus replication in mammalian cells indicates the importance of maintaining cell membrane integrity.This study confirms the importance of bibliometric analysis in detecting and understanding the impact of COVID-19 at the genomic level, proposing several potential research targets and enhancing our understanding of the biological response to viral infection.

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Section: Genomic Instabilitymentioning

confidence: 99%

Mapping the Genomic Impact of the COVID-19 Virus

Ikawaty,

Efendi Marzuki HY,

Baharuddin

2024

Preprint

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“…The interactions between SARS-CoV-2 and the host may result in a wide range of different pathways being affected by this virus. Continuing the topic of the effect of SARS-CoV-2 on the nervous system, it has been shown that the virus may be involved in pathogenesis (Nazari et al, 2021) by initiating/stimulating chromosomal instability of neurons (Pennisi et al, 2020;Iourov and Vorsanova, 2022). About 88% (78/88) of patients with COVID-19 with a severe course of the disease were found to have neurological manifestations, including acute cerebral circulation disorder and impaired consciousness (Zou et al, 2020).…”

Section: Sars-cov-2 and Brain Tissuesmentioning

confidence: 99%

“…COVID-19 has been shown to be associated with neurodegeneration (including Alzheimer's disease) due not only to advanced age of some elderly patients, but also to chromosome/genome instability due to coronavirus infection (Alves et al, 2020). In this case, chromosomal instability is superimposed on genomic abnormalities of brain cells associated with age-related chromosomal instabilities, leading to a complex of brain diseases (Xu et al, 2020b;Iourov and Vorsanova, 2022). Some authors confirmed that the long-term effects of SARS-CoV-2 infection may contribute to the development of Alzheimer's disease or other forms of dementia over time (de Erausquin et al, 2021;Douaud et al, 2022).…”

Section: Sars-cov-2 and Brain Tissuesmentioning

confidence: 99%

The effects of SARS-CoV-2 on susceptible human cells

Klestova

2023

Acta Virol.

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The biological consequences of viral infection result from biochemical, physiological, structural, morphological and genetic changes in infected cells. In productive infections, virus-induced biological changes in cells may be closely related to the efficiency of viral replication or to the recognition of these cells by the immune system. These changes are usually associated with cytocidal viruses, as in the case of the pandemic coronavirus SARS-CoV-2, which causes COVID-19. Many of these changes are required for effective viral replication. The physiological state of living cells has a significant impact on the outcome of viral infection, as the host cell provides the synthetic machinery, key regulatory molecules and precursors for newly synthesised viral proteins and nucleic acids. This review focuses on novel target cell types for SARS-CoV-2 exposure outside the respiratory tract. Findings and examples are collected that provide information on virus-cell interactions. The identification of unusual target cells for SARS-CoV-2 may help to explain the diverse symptoms in COVID-19 patients and the long-lasting effects after infection. In particular, the discovery of previously undescribed target cells for SARS-CoV-2 action needs to be considered to improve treatment of patients and prevention of infection.

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“…Therefore, as noticed previously [129], environmental interactions with changed genomes should not be left aside in studies dedicated to somatic cell genomics of brain disorders. To support this idea, one can refer to the ability of the notorious COVID-19 virus to produce aging-related genome/chromosome instability in the diseased brain [140]. Thus, therapeutic interventions based on analysis of brain-specific somatic mosaicism are to be developed taking into account genetic-environmental interactions.…”

Section: What Is Now and What Is Next?mentioning

confidence: 99%

Somatic mosaicism in the diseased brain

et al. 2022

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It is hard to believe that all the cells of a human brain share identical genomes. Indeed, single cell genetic studies have demonstrated intercellular genomic variability in the normal and diseased brain. Moreover, there is a growing amount of evidence on the contribution of somatic mosaicism (the presence of genetically different cell populations in the same individual/tissue) to the etiology of brain diseases. However, brain-specific genomic variations are generally overlooked during the research of genetic defects associated with a brain disease. Accordingly, a review of brain-specific somatic mosaicism in disease context seems to be required. Here, we overview gene mutations, copy number variations and chromosome abnormalities (aneuploidy, deletions, duplications and supernumerary rearranged chromosomes) detected in the neural/neuronal cells of the diseased brain. Additionally, chromosome instability in non-cancerous brain diseases is addressed. Finally, theoretical analysis of possible mechanisms for neurodevelopmental and neurodegenerative disorders indicates that a genetic background for formation of somatic (chromosomal) mosaicism in the brain is likely to exist. In total, somatic mosaicism affecting the central nervous system seems to be a mechanism of brain diseases.

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COVID-19 and Aging-Related Genome (Chromosome) Instability in the Brain: Another Possible Time-Bomb of SARS-CoV-2 Infection

Cited by 6 publications

References 29 publications

Mapping the Genomic Impact of the COVID-19 Virus

Mapping the Genomic Impact of the COVID-19 Virus

The effects of SARS-CoV-2 on susceptible human cells

Somatic mosaicism in the diseased brain

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