COVID‐19 and asthma, the good or the bad?

Wang, Jiu Yao; Pawankar, Ruby; Tsai, Hui Ju; Wu, Lawrence Shih Hsin; Kuo, Wen Shuo

doi:10.1111/all.14480

Cited by 29 publications

(67 citation statements)

References 10 publications

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“…[2] Furthermore, conventional therapeutics used for asthma control, including inhaled corticosteroids, [10] and anti-IgE monoclonal antibody, seem to provide beneficial effects, reducing the risk of COVID-19 infection. [3,11] Recent studies have shown that blocking IgE could reduce susceptibility to respiratory virus infection. Taken together, these observations suggest a potential effect of omalizumab on antiviral responses.…”

Section: Discussionmentioning

confidence: 99%

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Do Severe Pediatric Asthma Patients Have an Increased Susceptibility of Being Infected by Covid-19?

Farzanegan

Michavila

et al. 2020

Preprint

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Background: The Coronavirus disease 2019 caused by SARS-CoV2 virus has rapidly spread worldwide becoming one of the most important challenges humans are facing nowadays. Risk factors for severe outcomes have been identified, but asthma seems not to be one of them. Objectives: To analyze lifestyle before the pandemic in severe pediatric asthma patients in treatment with a monoclonal antibody, belonging to Castellon's Universitary General Hospital Health's Department, and investigate the prevalence of COVID-19 in these patients in order to see if their lifestyle may have influenced the probability of being infected by COVID-19. Methods: A questionnaire was developed asking about: their lifestyle before the pandemic; suggestive COVID-19 symptoms and exposition to the disease; and patients' behavior, asthma control and treatment during the pandemic. Total SARS-Cov-2 antibody tests were performed to all patients. Results: A total of 15 patients were included. All patients had a high social exposure before the pandemic. 2 patients had direct contact with positive COVID-19 patients. Both experienced mild symptoms that could be attributed to the disease, but neither of them had a positive serological test. Most patients followed asthma treatment correctly before and during the pandemic. 13 patients referred good asthma control. Most patients continued monthly monoclonal antibody administration. Serological tests were negative for all patients. Conclusion: Severe asthma pediatric patients in treatment with MAB, do not have an increased susceptibility for being infected by the virus, but in the case that they contracted the disease, evidence says they would have shown very weak symptoms.

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Section: Discussionmentioning

confidence: 99%

“…However, recent reports reveal that the prevalence of COVID-19 in asthma patients is lower than expected. [3] It seems that COVID-19 has less direct impact on children and adolescents than on adults. Only about 1% of the entire COVID-19 population are children, being pediatric asthma patients underrepresented in this population.…”

Section: Introductionmentioning

confidence: 99%

Do Severe Pediatric Asthma Patients Have an Increased Susceptibility of Being Infected by Covid-19?

Farzanegan

Michavila

et al. 2020

Preprint

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“…In contrast to other allergic and immunotoxic diseases that may be due to bioaerosol exposure, the significance of asthma in relation to COVID-19 has been studied and discussed by many authors [29][30][31][32][33][34][35][36][37][38][39][40]. Nevertheless, the data interpretation and conclusion formulation are difficult because of the variable prevalence of asthma in the general population, which is usually much greater in the USA and…”

Section: Respiratory Diseases Caused By Exposure To Occupational Bioamentioning

confidence: 99%

COVID 19 – Possible interrelations with respiratory comorbidities caused by occupational exposure to various hazardous bioaerosols. Part I. Occurrence, epidemiology and presumed origin of the pandemic

Dutkiewicz¹,

Maćkiewicz²,

Lemieszek³

2020

Ann Agric Environ Med.

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“…Since its first report in Wuhan, China, in December 2019, the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus has totally changed our life throughout the world [ 1 ]. ‘Stay home, stay safe.’ As of 9:00 a.m. July 30, 2020 (Korean standard time), total number of confirmed cases was 16,864,828 and the total number of deceased cases was 663,580 in the world [ 2 ].…”

mentioning

confidence: 99%

“…However, the prevalence of asthma and allergic diseases in patients with COVID-19 seems to be lower than expected so far [ 4 5 6 ]. Possible hypotheses have been suggested [ 1 ]. Firstly, reduced expression of angiotensin converting enzyme 2 (ACE2), a receptor for the docking spike glycoprotein of SARS-CoV-2 virus, and transmembrane protease serine 2 (TMPRSS2) which cleaves spike protein into two subunits for virus entry by membrane fusion in the mucosal membranes of asthma and respiratory allergy.…”

mentioning

confidence: 99%