2020
DOI: 10.1002/jmv.26346
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COVID‐19 and coagulation dysfunction in adults: A systematic review and meta‐analysis

Abstract: The outbreak of 2019 novel coronavirus disease (COVID-19) has posed a grave threat to the global public health. The COVID-19-induced infection is closely related to coagulation dysfunction in the affected patients. This paper attempts to conduct a meta-analysis and systematically review the blood coagulation indicators in patients with severe COVID-19. A meta-analysis of eligible studies was performed to compare the blood coagulation indicators in patients with severe and nonsevere COVID-19. PubMed, Embase, We… Show more

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Cited by 84 publications
(87 citation statements)
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“…The results of our phenotype analysis using mouse orthologs of shared human genes shows that phenotypic enrichment is consistent with the pathway enrichment using the human genes and is also consistent with pathologies associated with severe COVID-19: blood coagulation, inflammation and cardiovascular pathologies [36][37][38][39][40][41] . Since mice provide an attractive genetic system for disease modeling, we investigated the phenotypes associated with each of these genes in further detail.…”
Section: Identification Of Potential Mouse Models To Study Comorbiditsupporting
confidence: 81%
“…The results of our phenotype analysis using mouse orthologs of shared human genes shows that phenotypic enrichment is consistent with the pathway enrichment using the human genes and is also consistent with pathologies associated with severe COVID-19: blood coagulation, inflammation and cardiovascular pathologies [36][37][38][39][40][41] . Since mice provide an attractive genetic system for disease modeling, we investigated the phenotypes associated with each of these genes in further detail.…”
Section: Identification Of Potential Mouse Models To Study Comorbiditsupporting
confidence: 81%
“…Coagulation dysfunction is a consistent observation in human COVID-19 and has been associated with disease severity [18][19][20][21][22]. Here, we performed a limited analysis of blood clotting times (PT and aPTT) and circulating fibrinogen levels to begin to characterize the coagulopathy in SARS-CoV-2-infected AGMs.…”
Section: Discussionmentioning
confidence: 99%
“…Transient increases in aPTT and in circulating fibrinogen levels were observed during the acute phase of infection. Increases in PT and/ or aPTT have been linked to severe human COVID-19 cases in some but not all studies [18][19][20][21][22]. However, nearly all severe COVID-19 cases have been associated with high levels of fibrinogen [20][21][22].…”
Section: Discussionmentioning
confidence: 99%
“…In addition, however, megakaryocytes have been observed to produce blood platelets within the alveolar capillaries of COVID-19 patients [ 33 ]. In addition to altered blood platelet numbers, COVID-19 patients also present with alterations in a number of other elements of hemostasis, including coagulation times (thrombin times and prothrombin times), d-dimer concentrations and fibrinogen levels [ 4 , 25 , 34 , 35 ].…”
Section: Blood Platelet Count and Platelet Activation In Covid-19mentioning
confidence: 99%