COVID-19 and first manic episodes: a systematic review

Russo, Mirella; Rosa, Matteo A. De; Evangelista, Giacomo; Consoli, Stefano; Santilli, Matteo; Gambi, Francesco; Onofrj, Marco; Giannantonio, Massimo Di; Parruti, Giustino; Sensi, Stefano L.

doi:10.1016/j.psychres.2022.114677

Cited by 16 publications

(14 citation statements)

References 86 publications

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“…As previously mentioned, a host of confounding factors impede the study of mania in COVID patients. Another recent systematic review identified 21 additional cases of a first manic episode without a diagnosis of bipolar disorder following the SARS-CoV-2 infection [ 4 ]. The study adds further evidence to the correlation between manic episodes and COVID-19; however, the sample size was low.…”

Section: Discussionmentioning

confidence: 99%

“…Of course, viral infection, severe illness, and subsequent hospitalization are all psychologically stressful events that can exacerbate underlying psychiatric disorders like bipolar disorder. However, there have been multiple reports of first-time manic episodes occurring in the setting of a SARS-CoV-2 infection and in the absence of any previous psychiatric history [ 4 ]. This has brought into question whether these manic symptoms are in fact a neuropsychiatric manifestation of COVID-19 itself.…”

Section: Introductionmentioning

confidence: 99%

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First Manic Episode Following SARS-CoV-2 Infection

Alihsan¹,

Kashfi²,

Roarke³

2023

Cureus

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Since the beginning of the COVID-19 pandemic, there have been reports of neuropsychiatric symptoms following infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), most notably mania and psychosis. However, despite the widely reported incidence of psychosis and mania following infection with SARS-CoV-2, a causal link between the virus and these neuropsychiatric symptoms has not been established. A myriad of confounding factors such as underlying psychiatric disorders, personal and family psychiatric histories, substance use, and treatment with steroids all have the ability to obscure a correlation between SARS-CoV-2 and subsequent psychiatric symptoms. Here we present a case of a manic episode in a 40-year-old male following a COVID-19 infection. He had no past psychiatric history, no family psychiatric history, and no history of substance use. This case is unique in that the patient lacks all these typical confounding variables. It should serve as an example of a first-time manic episode following a recent infection with SARS-CoV-2. It may contribute data to future investigations seeking to better elucidate the correlation between SARS-CoV-2 and neuropsychiatric symptoms such as mania.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

First Manic Episode Following SARS-CoV-2 Infection

Alihsan¹,

Kashfi²,

Roarke³

2023

Cureus

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“…Russo et al (2022) highlighted that the existing case reports have a significant inhomogeneity of diagnostic workups which hampered defining the common clinical features of COVID-19 in their systematic review. ( Russo et al, 2022 )…”

Section: Discussionmentioning

confidence: 99%

A rare clinical presentation after COVID-19: Manic episode with psychotic features

Balcioglu

Zorgor

GUCLU

et al. 2023

Psychiatry Research Case Reports

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“…The observation of the so-called “sickness behavior,” i.e., the behavioral changes observed in inflammatory conditions, characterized by changes in mood, social behavior, and cognition, has suggested a role of the immune system in the development of mood disorders ( 111 , 152 ). Even the SARS-CoV-2 infection has been related with the development of manic episodes ( 153 ). Moreover, a certain degree of association between BSD and autoimmune diseases is known ( 107 ) and a prior hospitalization due to an autoimmune disease or infection has been recognized as a risk factor for developing a major mood disorder ( 111 ).…”

Section: Pathophysiology Of Bsdmentioning

confidence: 99%

Bipolar spectrum disorders in neurologic disorders

et al. 2022

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Psychiatric symptoms frequently predate or complicate neurological disorders, such as neurodegenerative diseases. Symptoms of bipolar spectrum disorders (BSD), like mood, behavioral, and psychotic alterations, are known to occur – individually or as a syndromic cluster – in Parkinson’s disease and in the behavioral variant of frontotemporal dementia (FTD). Nonetheless, due to shared pathophysiological mechanisms, or genetic predisposition, several other neurological disorders show significant, yet neglected, clinical and biological overlaps with BSD like neuroinflammation, ion channel dysfunctions, neurotransmission imbalance, or neurodegeneration. BSD pathophysiology is still largely unclear, but large-scale network dysfunctions are known to participate in the onset of mood disorders and psychotic symptoms. Thus, functional alterations can unleash BSD symptoms years before the evidence of an organic disease of the central nervous system. The aim of our narrative review was to illustrate the numerous intersections between BSD and neurological disorders from a clinical-biological point of view and the underlying predisposing factors, to guide future diagnostic and therapeutical research in the field.

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COVID-19 and first manic episodes: a systematic review

Cited by 16 publications

References 86 publications

First Manic Episode Following SARS-CoV-2 Infection

First Manic Episode Following SARS-CoV-2 Infection

A rare clinical presentation after COVID-19: Manic episode with psychotic features

Bipolar spectrum disorders in neurologic disorders

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