COVID-19 and Fungal infections: a double debacle

Mina, Sara; Yaakoub, Hajar; Annweiler, Cédric; Dubée, Vincent; Papon, Nicolas

doi:10.1016/j.micinf.2022.105039

Cited by 21 publications

(10 citation statements)

References 145 publications

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“…Immunomodulatory therapy, which became part of the standard therapy for COVID-19, is known to influence the fungal burden in the microbiome. Recent studies have described an increase in deaths from fungal infections during the COVID-19 pandemic ( Mina et al, 2022 ; Gold et al, 2023 ). A history of proton pump inhibitors (PPI) is a risk factor for the identification of Candida ( Mojazi Amiri et al, 2012 ), but PPIs were prescribed proportionally at 32% in both severity groups.…”

Section: Discussionmentioning

confidence: 99%

Hospital antimicrobial stewardship: profiling the oral microbiome after exposure to COVID-19 and antibiotics

Buendia,

Fernandez,

Raley

et al. 2024

Front. Microbiol.

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IntroductionDuring the COVID-19 Delta variant surge, the CLAIRE cross-sectional study sampled saliva from 120 hospitalized patients, 116 of whom had a positive COVID-19 PCR test. Patients received antibiotics upon admission due to possible secondary bacterial infections, with patients at risk of sepsis receiving broad-spectrum antibiotics (BSA).MethodsThe saliva samples were analyzed with shotgun DNA metagenomics and respiratory RNA virome sequencing. Medical records for the period of hospitalization were obtained for all patients. Once hospitalization outcomes were known, patients were classified based on their COVID-19 disease severity and the antibiotics they received.ResultsOur study reveals that BSA regimens differentially impacted the human salivary microbiome and disease progression. 12 patients died and all of them received BSA. Significant associations were found between the composition of the COVID-19 saliva microbiome and BSA use, between SARS-CoV-2 genome coverage and severity of disease. We also found significant associations between the non-bacterial microbiome and severity of disease, with Candida albicans detected most frequently in critical patients. For patients who did not receive BSA before saliva sampling, our study suggests Staphylococcus aureus as a potential risk factor for sepsis.DiscussionOur results indicate that the course of the infection may be explained by both monitoring antibiotic treatment and profiling a patient’s salivary microbiome, establishing a compelling link between microbiome and the specific antibiotic type and timing of treatment. This approach can aid with emergency room triage and inpatient management but also requires a better understanding of and access to narrow-spectrum agents that target pathogenic bacteria.

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Section: Discussionmentioning

confidence: 99%

Hospital antimicrobial stewardship: profiling the oral microbiome after exposure to COVID-19 and antibiotics

Buendia,

Fernandez,

Raley

et al. 2024

Front. Microbiol.

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“…Multiple articles regarding the association between invasive mold infections (especially aspergillosis) and severe or critical forms of COVID-19 were published [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Similarly to our cases, when COVID-19 was associated with aspergillosis, the mortality rate was very high [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Filamentous Fungi Infections: Yet Another Victim of COVID-19?

Cighir

Mare

Cighir

et al. 2023

Life

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Filamentous fungi have always been a matter of concern in the medical field, but nowadays, due to an increase in the risk factors and the added infections with the SARS-CoV-2 virus, they are slowly but surely emerging as a dangerous health threat worldwide. Our study aims to estimate the incidence of mold infections in central Romania, as well as assess the impact the pandemic had on them while evaluating other parameters such as age, associated bacterial and fungal infections and comorbidities. Purulent discharge and respiratory secretion specimens were collected and analyzed over a period of 10 years. A total of 68 samples tested positive for molds, with an increased number of positive samples during the pandemic. The highest number of specimens came from the outpatient department, followed by medical wards, with the most common filamentous fungus being Aspergillus section Flavi. Associated diseases included affections of the respiratory system, followed by the cardiovascular system and people who suffered from a viral infection with SARS-CoV-2, and they were mostly present in seniors. The most common associated infections were with Staphylococcus aureus and Candida nonalbicans. A statistically significant correlation was found between the association of mold infection and SARS-CoV-2 and an increase in mortality.

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“…pneumoniae ) have also been implicated in causing ARIs [ 3 – 5 ]. Single or mixed infections of fungi such as Candida albicans ( C. Albicans ) and Pneumocystis jirovecii can also cause ARIs [ 6 ]. ARIs pose significant health risks, particularly among vulnerable populations such as young children, older adults, and individuals with underlying health conditions.…”

Section: Introductionmentioning

confidence: 99%

Changes in Spectrum of Respiratory Pathogen Infections and Disease Severity Among Children in Hohhot, China: Impact of COVID-19 Prevention Measures

Gan,

Yang,

Liu

et al. 2024

Med Sci Monit

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Background This retrospective study evaluated the effects of specific COVID-19 preventive measures, including the use of medical masks, nucleic acid testing, and patient isolation, on respiratory infections, disease severity, and seasonal patterns among children in Hohhot, located in northern China. Understanding these alterations is pivotal in developing effective strategies to handle pediatric respiratory infections within the context of continuous public health initiatives. Material/Methods At the First Hospital of Hohhot, throat swabs were collected from 605 children with community-acquired respiratory between January 2022 and March 2023 for pathogen infection spectrum detection using microarray testing. Results Among the patients, 56.03% were male, and their average age was 3.45 years. SARS-CoV-2 infections were highest between October 2022 and January 2023. Influenza A peaked in March 2023, and other pathogens such as respiratory syncytial virus and influenza B virus disappeared after December 2022. The proportion of mixed infections was 41.94% among SARS-CoV-2 patients, while other pathogens had mixed infection rates exceeding 57.14%. Before December 2022, the mean WBC count for Streptococcus pneumoniae and Haemophilus influenzae was 8.83×10 9 /L, CRP was 18.36 mg/L, and PCT was 1.11 ng/ml. After December 2022, these values decreased significantly. Coughing, difficulty breathing, running nose, and lower respiratory tract infection diagnoses decreased in December 2022, except for SARS-CoV-2 infections. Conclusions SARS-CoV-2 peaked around November 2022, influenza A peaked in March 2023, and other pathogens like respiratory syncytial virus and influenza B virus were greatly reduced after December 2022. Inflammatory markers and respiratory symptoms decreased after December 2022, except for SARS-CoV-2.

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COVID-19 and Fungal infections: a double debacle

Cited by 21 publications

References 145 publications

Hospital antimicrobial stewardship: profiling the oral microbiome after exposure to COVID-19 and antibiotics

Hospital antimicrobial stewardship: profiling the oral microbiome after exposure to COVID-19 and antibiotics

Filamentous Fungi Infections: Yet Another Victim of COVID-19?

Changes in Spectrum of Respiratory Pathogen Infections and Disease Severity Among Children in Hohhot, China: Impact of COVID-19 Prevention Measures

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