COVID-19 and Glomerular Diseases

Klomjit, Nattawat; Zand, Ladan; Cornell, Lynn D.; Alexander, Mariam P.

doi:10.1016/j.ekir.2023.03.016

Cited by 19 publications

(17 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since early in the pandemic, multiple case reports have reported glomerular diseases in temporal relation to COVID-19. A recent review 7 summarizes published data on 511 native and 85 transplant kidney biopsies performed after SARS-CoV-2 infection, of which the vast majority were cases of collapsing glomerulopathy (i.e. COVAN), followed by podocytopathy (primary FSGS and MCD), diabetic nephropathy, and a variety of other histological diagnoses.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Incidence of Common Glomerular Diseases Other Than Collapsing Glomerulopathy is Not Increased After SARS-CoV-2 Infection

Diebold,

Enzler-Tschudy,

Helmchen

et al. 2024

Kidney International Reports

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“… 6 In addition to these 2 well-recognized renal manifestations of COVID-19, numerous case reports and case series have described a variety of other renal diseases, mostly glomerulopathies, manifesting in temporal association with SARS-CoV-2 infection. 7 …”

Section: Introductionmentioning

confidence: 99%

Incidence of Common Glomerular Diseases Other Than Collapsing Glomerulopathy is Not Increased After SARS-CoV-2 Infection

Diebold,

Enzler-Tschudy,

Helmchen

et al. 2024

Kidney International Reports

View full text Add to dashboard Cite

“…COVID-19-induced AKI and glomerular disease pathogenesis involve various mechanisms, including hypoperfusion, cytokine storm, endothelial injury, and potential direct kidney infection [ 3 ]. In our case series, COVID-19-infected patients displayed diverse glomerular diseases and frequently presented with AKI, likely attributable to COVID-19 [ 14 ]. The most frequently observed glomerular disorder was podocytopathy, comprising one case of collapsing variant FSGS and two cases of MCD.…”

Section: Discussionmentioning

confidence: 99%

“…Collapsing variant FSGS (collapsing glomerulopathy) is the most common type of GN observed in COVID-19 patients. It is believed to be induced by immune dysregulation triggered by COVID-19 [ 14 ]. In addition, we identified newly diagnosed IgAN and HSP in COVID-19 patients.…”

Section: Discussionmentioning

confidence: 99%

“…This evaluation helped establish the difference in the proportion of newly diagnosed GN cases at Severance Hospital before and after the commencement of the nationwide vaccination program (April 1, 2021), and before and after the peak of the COVID-19 pandemic (February 1, 2022) in South Korea. This approach considered that the nationwide vaccine program began in March 2021, and COVID-19 cases surged significantly as of February 2022 in South Korea, considering weeks of latent period [ 1 , 2 , 4 , 14 ]. An additional time-series analysis was conducted using an autoregressive integrated moving average (ARIMA) model.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Glomerulonephritis following COVID-19 infection or vaccination: a multicenter study in South Korea

Kim,

Roh

et al. 2024

Kidney Res Clin Pract

View full text Add to dashboard Cite

Background: Despite the widespread impact of the severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019, COVID-19) and vaccination in South Korea, our understanding of kidney diseases following these events remains limited. We aimed to address this gap by investigating the characteristics of glomerular diseases following the COVID-19 infection and vaccination in South Korea. Methods: Data from multiple centers were used to identify de novo glomerulonephritis (GN) cases with suspected onset following COVID-19 infection or vaccination. Retrospective surveys were used to determine the COVID-19–related histories of patients who were initially not implicated. Bayesian structural time series and autoregressive integrated moving average models were used to determine causality. Results: Glomerular diseases occurred shortly after the infection or vaccination. The most prevalent postinfection GN was podocytopathy (42.9%), comprising primary focal segmental glomerulosclerosis and minimal change disease, whereas postvaccination GN mainly included immunoglobulin A nephropathy (IgAN; 57.9%) and Henoch-Schönlein purpura nephritis (HSP; 15.8%). No patient progressed to end-stage kidney disease. Among the patients who were initially not implicated, nine patients with IgAN/HSP were recently vaccinated against COVID-19. The proportion of glomerular diseases changed during the pandemic in South Korea, with an increase in acute interstitial nephritis and a decrease in pauci-immune crescentic GN. Conclusion: This study showed the characteristics of GNs following COVID-19 infection or vaccination in South Korea. Understanding these associations is crucial for developing effective patient management and vaccination strategies. Further investigation is required to fully comprehend COVID-19’s impact on GN.

show abstract