COVID-19 and hepatic injury: Diversity and risk assessment

Ali, Fares E.M.; El-Aziz, Mostafa K Abd; Ali, Mahmoud Mohammed Ahmed; Ghogar, Osama M; Bakr, Adel G.

doi:10.3748/wjg.v29.i3.425

Cited by 13 publications

(10 citation statements)

References 241 publications

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“… 20 Potential mechanisms for AHF and AKI in COVID-19 include cytokine storm, macrophage activation syndrome, lymphopenia endothelial dysfunction, hypercoagulability, ischemic injury, and sepsis. 21 , 22 Similar mechanisms involving endothelial dysfunction, mitochondrial dysfunction, coagulopathy, SIRS, and ischemic injury have also been implicated in the pathogenesis of HS-induced AHF and AKI. 23 , 24 The prolonged effects of SARS-CoV-2 necessitated the continuation of CRRT and liver protection therapy in patients with HS.…”

Section: Discussionmentioning

confidence: 99%

Heatstroke Comorbid with SARS-CoV-2 Infection: A Case Report and Literature Review

Ni,

Liu,

Zeng

et al. 2024

IMCRJ

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Background Hyperthermia and multiple organ dysfunction syndrome (MODS) are the main characteristics of heatstroke and COVID-19. Differentiating between these illnesses is crucial during a summer COVID-19 pandemic, but cases of heatstroke comorbid with COVID-19 are rarely reported. Case description We report the first case of heatstroke comorbid with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in a 52-year-old male. After receiving intravenous antibiotics, organ protection measures, and treatment for coagulation disorders, his fever and coma resolved. However, he developed dyspnea and cerebral hemorrhage after several days. This patient experienced a multi-pathogen pulmonary infection and an intractable coagulopathy that ultimately resulted in MODS and death. Conclusion The combination of heatstroke and SARS-CoV-2 infection exacerbated inflammation, immune abnormalities, and coagulation disorders. The interaction between inflammation and coagulation disturbances contributed to the underlying mechanism in this case, highlighting the importance of early anti-infection, treatment for coagulopathy, immune regulation, and organ protection as crucial interventions.

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Section: Discussionmentioning

confidence: 99%

Heatstroke Comorbid with SARS-CoV-2 Infection: A Case Report and Literature Review

Ni,

Liu,

Zeng

et al. 2024

IMCRJ

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“…On the other hand, previously diagnosed viral hepatitis was not found as a triggering factor for liver damage after being infected with the coronavirus [182]. According to global data, the overall risk of a severe course and death because of COVID-19 in patients with CLD becomes 2.44 times greater in comparison to the population with no hepatic problems [183][184][185]. The global multicenter experience (the United States, Europe and China) with cirrhotic patients treated due to SARS-CoV-2 infection gives the perspective of the significantly higher mortality rate among these individuals (up to 35%) compared to the non-cirrhotic population [186][187][188].…”

Section: Covid-19 In Patients With Pre-existing Liver Failure-general...mentioning

confidence: 97%

COVID-19, Possible Hepatic Pathways and Alcohol Abuse—What Do We Know up to 2023?

Michalak,

Lach,

Szczygieł

et al. 2024

IJMS

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The pandemic period due to coronavirus disease 2019 (COVID-19) revolutionized all possible areas of global health. Significant consequences were also related to diverse extrapulmonary manifestations of this pathology. The liver was found to be a relatively common organ, beyond the respiratory tract, affected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Multiple studies revealed the essential role of chronic liver disease (CLD) in the general outcome of coronavirus infection. Present concerns in this field are related to the direct hepatic consequences caused by COVID-19 and pre-existing liver disorders as risk factors for the severe course of the infection. Which mechanism has a key role in this phenomenon—previously existing hepatic disorder or acute liver failure due to SARS-CoV-2—is still not fully clarified. Alcoholic liver disease (ALD) constitutes another not fully elucidated context of coronavirus infection. Should the toxic effects of ethanol or already developed liver cirrhosis and its consequences be perceived as a causative or triggering factor of hepatic impairment in COVID-19 patients? In the face of these discrepancies, we decided to summarize the role of the liver in the whole picture of coronavirus infection, paying special attention to ALD and focusing on the pathological pathways related to COVID-19, ethanol toxicity and liver cirrhosis.

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“…I like paper “COVID-19 and hepatic injury: Diversity and risk assessment” because it provides in-depth insight into the cellular and molecular mechanisms of several liver cell types. To better highlight the study’s precise topic, I suggest changing the title to: “COVID-19 and hepatic injury: Cellular and molecular mechanisms in diverse liver cells”[ 10 ].…”

Section: Hot Articles and Insufficient Articlesmentioning

confidence: 99%

Editor-in-Chief articles of choice and comments at the year-end of 2023

Tarnawski

2024

World J Gastroenterol

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As the Editor-in-Chief, every week prior to a new issue’s online publication, I perform a careful review of all encompassed articles, including the title, clinical and/or research importance, originality, novelty, and ratings by the peer reviewers. Based on this review, I select the papers of choice and suggest pertinent changes (e.g. , in the title) to the Company Editors responsible for publication. This process, while time-consuming, is very important for assuring the quality of publications and highlighting important articles that Readers may revisit.

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COVID-19 and hepatic injury: Diversity and risk assessment

Cited by 13 publications

References 241 publications

Heatstroke Comorbid with SARS-CoV-2 Infection: A Case Report and Literature Review

Heatstroke Comorbid with SARS-CoV-2 Infection: A Case Report and Literature Review

COVID-19, Possible Hepatic Pathways and Alcohol Abuse—What Do We Know up to 2023?

Editor-in-Chief articles of choice and comments at the year-end of 2023

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