2021
DOI: 10.1111/jocd.14022
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COVID‐19 and human papillomavirus: Paradoxical immunity

Abstract: Coronavirus disease 2019 (COVID‐19) is a multisystemic disease that can cause progressive lung failure, organ dysfunction, and coagulation disorder associated with high mortality and morbidity. COVID‐19 is known to either primarily cause skin symptoms or increase existing skin diseases. Human papillomavirus (HPV) is a DNA virus that can cause benign and malignant neoplasms. Mucocutaneous verruca vulgaris are common benign lesions of HPV. Here, we report a case of verruca vulgaris regressed after COVID‐19.

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Cited by 5 publications
(5 citation statements)
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References 14 publications
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“…Clustal_W analysis results gave approximately 21% similarity with SARS-nCoV-2 nucleocapsid protein. The results suggest the drug repurposing opportunity with the identification of a similar category of drugs with a high affinity towards SARS-nCoV-2 viral proteins 15 , 39 . Table 4 is also suggesting affinity towards a viral protein Baculoviral IAP repeat-containing protein 40 .…”
Section: Resultsmentioning
confidence: 82%
“…Clustal_W analysis results gave approximately 21% similarity with SARS-nCoV-2 nucleocapsid protein. The results suggest the drug repurposing opportunity with the identification of a similar category of drugs with a high affinity towards SARS-nCoV-2 viral proteins 15 , 39 . Table 4 is also suggesting affinity towards a viral protein Baculoviral IAP repeat-containing protein 40 .…”
Section: Resultsmentioning
confidence: 82%
“…We have found one confirmed mimicry epitope, FKEELD from SARS-CoV-2 and OC43 Spike proteins. Other predicted events of antibody cross-reactivity of SARS-CoV-2 Spike with HPV-16, HIV-1, and Dengue virus were suggested by previous literature (Demirbaş et al, 2021;Mannar et al, 2021;Lustig et al, 2021). Unlike previous studies (Balbin et al, 2021;Ludin et al, 2011;Doxey and McConkey, 2013), the EMoMiS pipeline can predict the exact site of molecular mimicry, thus opening the door for further experimentation.…”
Section: Discussionmentioning
confidence: 85%
“…HPV is a DNA virus that can cause benign and malignant neoplasms (Molijn et al ., 2005). A recent study reported a patient for which persistent verruca vulgaris (benign HPV warts) paradoxically regressed after recovery from COVID-19 (Demirbaş et al ., 2021). However, we hypothesize that the HPV vaccine will not be effective against COVID-19, as the predicted motif KHTP is not included in the list of cross-neutralizing epitopes (Tumban et al ., 2011).…”
Section: Discussionmentioning
confidence: 99%
“…Human papillomaviruses vaccination is considered a safe and effective measure to prevent the infection and further complications [ 12 , 13 ]. According to a recent case report, verruca vulgaris, a common benign HPV lesion, regressed after COVID-19, suggesting a possible negative correlation between COVID‐19 and HPV infections [ 14 ]. There is growing evidence that the innate immune system may be able to acquire trained immunity, which works against a wide range of infectious diseases and possibly for extended periods of time [ 15 , 16 ].…”
Section: Introductionmentioning
confidence: 99%