COVID-19 and hypercoagulability in the outpatient setting

Emert, Roger; Shah, Pranay; Zampella, John G.

doi:10.1016/j.thromres.2020.05.031

Cited by 26 publications

(28 citation statements)

References 18 publications

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“…To our knowledge, this is the first report of an MIS-C case manifesting with extensive aortic and branch artery abnormalities including aortitis, mural thrombus, saccular aneurysms and severe stenosis of the left renal artery ostium. The thrombotic findings are concordant with the hypercoagulable state described in adult patients with SARS-CoV-2 [ 9 , 10 ]. The patient exhibited ASO, ANA, anti-Ro/SSA and anti-thyroid antibodies that are not typically associated with large vessel vasculitis, and were possibly related to the immunologic response associated with MIS-C.…”

Section: Discussionsupporting

confidence: 81%

A Large-Vessel Arteritis in SARS-CoV-2–related Multisystem Inflammatory Syndrome in Children

Salman

Masand

Huisman

et al. 2021

Radiology: Cardiothoracic Imaging

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Section: Discussionsupporting

confidence: 81%

A Large-Vessel Arteritis in SARS-CoV-2–related Multisystem Inflammatory Syndrome in Children

Salman

Masand

Huisman

et al. 2021

Radiology: Cardiothoracic Imaging

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“… 36 Hypercoagulability, along with a systemic inflammatory response to the viral infection, could lead to macro- and microthrombi formation, ultimately eliciting cerebrovascular incidents. 37 , 38 A thromboelastography study of the coagulation profile in critical COVID-19 patients yielded consistency with a hypercoagulative state. It’s been postulated that substantially increased factor VIII is associated with COVID-19 related hypercoagulability.…”

Section: Mechanism Of Stroke In Covid-19 Patientsmentioning

confidence: 92%

COVID-19 and stroke: A review

Keith

Huang

2021

Brain Hemorrhages

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COVID-19 patients have presented with a wide range of neurological disorders, among which stroke is the most devastating. We have reviewed current studies, case series, and case reports with a focus on COVID-19 patients complicated with stroke, and presented the current understanding of stroke in this patient population. As evidenced by increased D-dimer, fibrinogen, factor VIII and von Willebrand factor, SARS-CoV-2 infection induces coagulopathy, disrupts endothelial function, and promotes hypercoagulative state. Collectively, it predisposes patients to cerebrovascular events. Additionally, due to the unprecedented strain on the healthcare system, stroke care has been inevitably compromised. The underlying mechanism between COVID-19 and stroke warrants further study, so does the development of an effective therapeutic or preventive intervention.

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“…Despite the clinical implications of thrombosis, little is known regarding clinical presentations and outcomes of outpatient thrombosis in COVID-19. 16 Data from the pre-COVID-19 era suggest that venous thromboembolism (VTE) occurring in outpatients has a more favorable prognosis than inpatient VTE. Outpatient thromboses outcomes in COVID-19 patients have not been evaluated.…”

Section: Introductionmentioning

confidence: 99%