COVID-19 and intestinal inflammation: Role of fecal calprotectin

Ojetti, Veronica; Saviano, Angela; Covino, Marcello; Acampora, Nicola; Troiani, Eliana; Franceschi, Francesco

doi:10.1016/j.dld.2020.09.015

Cited by 47 publications

(61 citation statements)

References 9 publications

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“…Among the eight included quantitative studies, five studies discussed the comparison of serum levels of calprotectin in severe and non-severe COVID-19 patients [12,14,[25][26][27] ( Table 3). Three of the studies reported a comparison of the fecal calprotectin [18,28,29] ( Table 3). The two included qualitative studies conducted an RNA-sequence analysis of a single cell [33,34] with reports documenting more elevated levels of calprotectin expression in severe compared to non-severe COVID-19 (Table 4).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The mean serum/fecal calprotectin was compared between the severe and non-severe groups of COVID-19 infection in these included studies (Figure 2). Among the included studies, all of the serum quantitative studies were considered to be of good quality [12,14,[25][26][27] while two of the fecal studies were of good quality [28,29] except Effenberger et al [18], which was considered to be of moderate quality (Table 2). Further, the two included studies in the qualitative category had good (Unterman et al) [33] and low (Livanos et al) [34] quality respectively (Table 4).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Congruent upon the I 2 , is the chi-squared statistic (Q) which is 46.7 on seven degrees of freedom with a low p-value of 0.001, which is statistically significant. [14]; De Guadiana et al [25]; Shi et al [26]; Silvin et al [12]; Bauer et al [27]; Effenberger et al [16]; Ojetti et al [28]; Britton et al [29]. C. Funnel plot showing some publication bias.…”

Section: Meta-analysis Forest Plot and Sensitivity Analysismentioning

confidence: 99%

“…Since there is substantial heterogeneity, there is a need to explore the data for possible causes. First of all, we conducted a subgroup analysis such that the data were analyzed as study group either reporting on serum calprotectin [study [1][2][3][4][5] [12,14,[25][26][27] or reporting on fecal calprotectin [study [6][7][8] [18,28,29]. The results respectively are as follows 1.17 [0.66, 1.67] I 2 = 79% p-value 0.001, and 1.66 [0.13, 3.19] I 2 = 93% with a p-value = 0.03.…”

Section: Subgroup Analysis and Meta-regressionmentioning

confidence: 99%

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Calprotectin, an Emerging Biomarker of Interest in COVID-19: A Systematic Review and Meta-Analysis

Udeh

Advani

Romualdo

et al. 2021

JCM

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COVID-19 has been shown to present with varied clinical course, necessitating a need for more specific diagnostic tools that could identify severe cases and predict outcomes during COVID-19 infection. Recent evidence has shown an expanded potential role for calprotectin, both as a diagnostic tool and also as a tool in stratifying COVID-19 patients in terms of severity. Therefore, this systematic review and meta-analysis aims to evaluate the levels of calprotectin in severe and non-severe COVID-19 and also identify the implication of raised calprotectin levels. MEDLINE, EMBASE, The Cochrane Library, Web of science and MedRxiv were searched. Meta-analysis was done to compare the serum/fecal levels of calprotectin between severe and non-severe COVID-19 infections. A total of ten studies included in the review (eight had quantitative data while two were qualitative). A pooled analysis of the eight studies from 613 patients who were RT-PCR positive for COVID-19 (average age = 55 years; 52% males) showed an overall estimate as 1.34 (95%CI: 0.77, 1.91). In conclusion, calprotectin levels have been demonstrated to be significantly elevated in COVID-19 patients who develop the severe form of the disease, and it also has prognostic importance.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Meta-analysis Forest Plot and Sensitivity Analysismentioning

confidence: 99%

Section: Subgroup Analysis and Meta-regressionmentioning

confidence: 99%

See 2 more Smart Citations

Calprotectin, an Emerging Biomarker of Interest in COVID-19: A Systematic Review and Meta-Analysis

Udeh

Advani

Romualdo

et al. 2021

JCM

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“…Moreover, patients with COVID-19-associated thrombosis had significantly higher blood levels of NETs and neutrophil activation markers such as CLP compared with COVID-19 patients without thrombosis [ 85 ]. Additionally, many studies support that fecal CLP indicates intestinal inflammation in COVID-19 [ 86 , 87 , 88 ].…”

Section: Clp In Respiratory Infectionsmentioning

confidence: 99%

Calprotectin in Lung Diseases

Kotsiou

Papagiannis

Papadopoulou

et al. 2021

IJMS

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Calprotectin (CLP) is a heterodimer formed by two S-100 calcium-binding cytosolic proteins, S100A8 and S100A9. It is a multifunctional protein expressed mainly by neutrophils and released extracellularly by activated or damaged cells mediating a broad range of physiological and pathological responses. It has been more than 20 years since the implication of S100A8/A9 in the inflammatory process was shown; however, the evaluation of its role in the pathogenesis of respiratory diseases or its usefulness as a biomarker for the appropriate diagnosis and prognosis of lung diseases have only gained attention in recent years. This review aimed to provide current knowledge regarding the potential role of CLP in the pathophysiology of lung diseases and describe how this knowledge is, up until now, translated into daily clinical practice. CLP is involved in numerous cellular processes in lung health and disease. In addition to its anti-microbial functions, CLP also serves as a molecule with pro- and anti-tumor properties related to cell survival and growth, angiogenesis, DNA damage response, and the remodeling of the extracellular matrix. The findings of this review potentially introduce CLP in daily clinical practice within the spectrum of respiratory diseases.

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Quantitative assessment of the impact of COVID-19 pandemic on pancreatic surgery: an Italian multicenter analysis of 1423 cases from 10 tertiary referral centers

et al. 2021

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COVID-19 and intestinal inflammation: Role of fecal calprotectin

Abstract: COVID-19 and intestinal inflammation: Role of fecal calprotectin ✩Dear Editor , ✩ The members of the GEMELLI AGAINST COVID-19 group can be found in the Appendix.

Cited by 47 publications

References 9 publications

Calprotectin, an Emerging Biomarker of Interest in COVID-19: A Systematic Review and Meta-Analysis

Calprotectin, an Emerging Biomarker of Interest in COVID-19: A Systematic Review and Meta-Analysis

Calprotectin in Lung Diseases

Quantitative assessment of the impact of COVID-19 pandemic on pancreatic surgery: an Italian multicenter analysis of 1423 cases from 10 tertiary referral centers

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