COVID-19 and Its Global Economic Impact

Kolahchi, Zahra; Domenico, Manlio De; Uddin, Lucina Q.; Cauda, Valentina; Grossmann, Igor; Lacasa, Lucas; Grancini, Giulia; Rezaei, Nima

doi:10.1007/978-3-030-63761-3_46

Cited by 75 publications

(43 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The global death toll of the COVID-19 pandemic has been estimated to 5.5 million over the first two years of its existence [ 2 ], with long-standing illness and long-term complications affecting several survivors [ 3 , 4 ]. Additionally, the COVID-19 pandemic has resulted in an unprecedented impact in practically all aspects of life, including international production and trade, with a subsequent global economic impact [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Attitudes and Determinants of Mandatory Vaccination against COVID-19 among the General Population of Cyprus: A Nationwide Cross-Sectional Study

2022

View full text Add to dashboard Cite

Vaccinations for the prevention of coronavirus disease (COVID-19) are important to control the ongoing pandemic. A much-discussed strategy to increase vaccination coverage is mandatory vaccination; however, its legitimacy and effectiveness as a measure are doubtful. This study aims to investigate the attitudes of the general population of Cyprus towards COVID-19 mandatory vaccination and to identify the factors influencing individuals’ attitudes towards such policy. An online cross-sectional study was conducted, using a self-administered, anonymous questionnaire to collect information on sociodemographic and health-related characteristics, trust, and satisfaction about the healthcare system and utilization of preventive healthcare services, COVID-19 vaccination information, general vaccination knowledge, and attitudes towards mandatory vaccination. A total of 2140 participants completed the survey, with 27.8% being in favor of mandatory vaccination. We found that as the age increases by one year, the odds of supporting mandatory vaccination increase by 1.04 units (OR 1.04, 95% CI: 1.02–1.05). In addition, those who reported increased trust in national healthcare authorities’ guidelines and recommendations (OR 3.74, 95% CI: 3.11–4.49) and those satisfied with the healthcare system (OR 1.38, 95% CI: 1.16–1.65) and follow doctor’s instructions (OR 1.29, 95% CI: 1.03–1.61), were significantly more likely to support mandatory vaccination while those who had underage children living in the household were significantly less likely to support mandatory vaccination (OR 0.69, 95% CI: 0.50–0.94). Public health authorities need to develop well-organized vaccination campaigns in which accurate evidence-based information would be disseminated with respect to individuals’ autonomy.

show abstract

Section: Introductionmentioning

confidence: 99%

Attitudes and Determinants of Mandatory Vaccination against COVID-19 among the General Population of Cyprus: A Nationwide Cross-Sectional Study

2022

View full text Add to dashboard Cite

show abstract

“…One stream of research studies the influence of the COVID-19 on economic growth, foreign trade, employment, production and consumption, for example, in terms of economy, studies on the impact of COVID-19 on the economy and relevant measures taken by various countries to solve the problem [ 5 , 6 ]. Studies show that the epidemic has a huge impact on the world economy and will cause a loss of more than 2.2 billion US dollars to the world GDP by the end of 2020 [ 7 , 8 ]. Countermeasures and suggestions are proposed based on the characteristics of various industries from the policy, economic and financial levels [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Study on the influence of COVID-19 on the growth of China’s small and medium-sized construction enterprises

et al. 2022

View full text Add to dashboard Cite

The outbreak of COVID-19 at the beginning of 2020 had a significant impact on China’s economy, society, and citizens; it also had a negative impact on the development of the construction industry. In particular, small and medium-sized construction enterprises with low ability to withstand risk have been strongly impacted, aggravating a crisis of survival among these firms. The focus of this study is to analyze the impact of COVID-19 on the growth of small and medium-sized construction companies. Based on the characteristics of small and medium-sized construction enterprises, this paper establishes a growth evaluation index and builds a growth evaluation model based on factor analysis. Twenty-three construction enterprises listed on small and medium-sized enterprises board are selected as samples, and the quarterly data of 2019 and 2020 are used for empirical analysis. The results show that the epidemic has had a high short-term impact on construction enterprises, and the total output value of the construction industry in the first quarter of 2020 was 16% lower than that in the same period of last year. In the long run, the impact of the epidemic on the growth of small and medium-sized construction enterprises has been limited. In the first quarter of 2020, the growth score of enterprises decreased by only 1.95% year-over-year, and it was essentially flat in the second and third quarters. The epidemic has had little influence on solvency, tangible resources or intangible resources but a high short term influence on profitability, capital expansion and market expectations. The long-term impact is small; It is conducive to the improvement of enterprise operation ability. Finally, to both address the influence of the COVID-19 on small and medium-sized construction enterprises and to realize their transformation and upgrading, targeted suggestions are offered at the policy and enterprise levels. The results will help to understand the impact of the epidemic on the growth of construction enterprises, and provide decision support for the healthy and orderly development of the follow-up construction industry.

show abstract

“…SARS-CoV-2 causes coronavirus disease 2019 (COVID-19), which was declared a global pandemic on March 11, 2020. The rapid national and international spread of SARS-CoV-2 has threatened human health and led to a global economic recession [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Trypsin enhances SARS-CoV-2 infection by facilitating viral entry

et al. 2022

View full text Add to dashboard Cite

Coronaviruses infect cells by cytoplasmic or endosomal membrane fusion, driven by the spike (S) protein, which must be primed by proteolytic cleavage at the S1/S2 furin cleavage site (FCS) and the S2′ site by cellular proteases. Exogenous trypsin as a medium additive facilitates isolation and propagation of several coronaviruses in vitro. Here, we show that trypsin enhances severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in cultured cells and that SARS-CoV-2 enters cells via either a non-endosomal or an endosomal fusion pathway, depending on the presence of trypsin. Interestingly, trypsin enabled viral entry at the cell surface and led to more efficient infection than trypsin-independent endosomal entry, suggesting that trypsin production in the target organs may trigger a high level of replication of SARS-CoV-2 and cause severe tissue injury. Extensive syncytium formation and enhanced growth kinetics were observed only in the presence of exogenous trypsin when cell-adapted SARS-CoV-2 strains were tested. During 50 serial passages without the addition of trypsin, a specific R685S mutation occurred in the S1/S2 FCS ( 681 PRRAR 685 ) that was completely conserved but accompanied by several mutations in the S2 fusion subunit in the presence of trypsin. These findings demonstrate that the S1/S2 FCS is essential for proteolytic priming of the S protein and fusion activity for SARS-CoV-2 entry but not for viral replication. Our data can potentially contribute to the improvement of SARS-CoV-2 production for the development of vaccines or antivirals and motivate further investigations into the explicit functions of cell-adaptation-related genetic drift in SARS-CoV-2 pathogenesis.

show abstract

COVID-19 and Its Global Economic Impact

Cited by 75 publications

References 86 publications

Attitudes and Determinants of Mandatory Vaccination against COVID-19 among the General Population of Cyprus: A Nationwide Cross-Sectional Study

Attitudes and Determinants of Mandatory Vaccination against COVID-19 among the General Population of Cyprus: A Nationwide Cross-Sectional Study

Study on the influence of COVID-19 on the growth of China’s small and medium-sized construction enterprises

Trypsin enhances SARS-CoV-2 infection by facilitating viral entry

Contact Info

Product

Resources

About