COVID-19 and kidney transplantation: the impact of remdesivir on renal function and outcome - a retrospective cohort study

Elec, Florin Ioan; Magnusson, Jesper; Elec, Alina Daciana; Muntean, Adriana; Antal, Oana; Moisoiu, Tudor; Cismaru, Cosmin Andrei; Lupşe, Mihaela; Oltean, Mihai

doi:10.1016/j.ijid.2022.03.015

Cited by 20 publications

(24 citation statements)

References 23 publications

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“…Other strategies for the management of COVID-19 remain similar to the general population. Remdesivir is reported to be safe in KTR [ 103 , 104 ].…”

Section: Clinical Outcomes Of Covid-19 In Kidney Transplant Recipientsmentioning

confidence: 99%

COVID-19 and Kidney Disease: Progress in Health Inequity From Low-Income Settings

Tannor

Bajpal²,

Nlandu

et al. 2022

Seminars in Nephrology

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“…Other strategies for the management of COVID-19 remain similar to the general population. Remdesivir is reported to be safe in KTR [ 103 , 104 ].…”

Section: Clinical Outcomes Of Covid-19 In Kidney Transplant Recipientsmentioning

confidence: 99%

COVID-19 and Kidney Disease: Progress in Health Inequity From Low-Income Settings

Tannor

Bajpal²,

Nlandu

et al. 2022

Seminars in Nephrology

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“…However, the sample size was very small, and tacrolimus doses were significantly reduced in 11 of 22 patients at admission before starting remdesivir. Similarly, in Elec et al 11 , tacrolimus was withdrawn or adjusted to lower trough levels in all patients before starting antiretrovirals. Otherwise, the incidence of AKI in this study was more than previously reported in patients receiving remdesivir for COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Potential Effects of Remdesivir on Tacrolimus Exposure in Transplant Recipients With COVID-19 Infection

Habeeb

Gabardi

Townsend

et al. 2023

Kidney International Reports

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“…Sotrovimab and remdesivir have been reported to significantly reduce mortality due to COVID‐19, and have no apparent nephrotoxic effects on renal transplant patients. 17 , 18 However, sufficient evidence has not yet been accumulated regarding steroid pulse therapy for COVID‐19 in renal transplant recipients. In a retrospective cohort study, treatment with methylprednisolone was shown to reduce the risk of death in patients with acute respiratory distress syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Sotrovimab and remdesivir have been reported to significantly reduce mortality due to COVID‐19, and have no apparent nephrotoxic effects on renal transplant patients 17,18 . However, sufficient evidence has not yet been accumulated regarding steroid pulse therapy for COVID‐19 in renal transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

Rapid deterioration of renal function following coronavirus disease 2019 in a renal transplant recipient

et al. 2022

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Introduction The coronavirus disease 2019 pandemic emerged in December 2019. Renal transplant recipients receiving chronic immunosuppression are considered to be at a high risk of infection. Aside from upper respiratory tract symptoms, coronavirus disease 2019 has also been reported to cause acute kidney injury in 20–50% of infected cases. Case presentation A 62‐year‐old male renal transplant recipient presented with high fever, diarrhea, and cough, concurrent with rapid deterioration of graft function. The patient tested positive for coronavirus disease 2019. The pathological findings of the graft biopsy revealed diffuse flattening of tubular epithelial cells and extensive loss of the brush border in proximal tubular cells. Mycophenolate mofetil was discontinued and sotrovimab, remdesivir, intravenous immunoglobulin, and intravenous methylprednisolone were administered, resulting in gradual improvements in clinical symptoms and renal function. Conclusion We describe a case of a coronavirus disease 2019‐infected kidney transplant recipient who developed severe acute kidney injury caused by severe acute tubular necrosis.

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COVID-19 and kidney transplantation: the impact of remdesivir on renal function and outcome - a retrospective cohort study

Cited by 20 publications

References 23 publications

COVID-19 and Kidney Disease: Progress in Health Inequity From Low-Income Settings

COVID-19 and Kidney Disease: Progress in Health Inequity From Low-Income Settings

Potential Effects of Remdesivir on Tacrolimus Exposure in Transplant Recipients With COVID-19 Infection

Rapid deterioration of renal function following coronavirus disease 2019 in a renal transplant recipient

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