COVID-19 and nutriceutical therapies, especially using zinc to supplement antimicrobials

Butters, Desley; Whitehouse, M. W.

doi:10.1007/s10787-020-00774-8

Cited by 14 publications

(8 citation statements)

References 28 publications

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“…The subclinical zinc deficiency might be responsible for the high incidence of infections and degenerative pathologies related to age. For example, as zinc is involved in the synthesis of bone matrix constituents, zinc deficiency is also a risk factor for age related osteoporosis [184,185]. Zinc supports components of the innate and adaptive immune systems, which include the three main lines of defence: epithelial barriers, cellular defences, and antibodies.…”

Section: Zincmentioning

confidence: 99%

The coronavirus disease (COVID-19) – A supportive approach with selected micronutrients

Gröber¹,

Holick

2022

International Journal for Vitamin and Nutrition Research

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Abstract. Worldwide the pandemic of COVID-19 spreads rapidly and has had an enormous public health impact with substantial morbidity and mortality especially in high-risk groups, such as older people and patients with comorbidities like diabetes, dementia or cancer. In the absence of a vaccine against COVID-19 there is an urgent need to find supportive therapies that can stabilize the immune system and can help to deal with the infection, especially for vulnerable groups such as the elderly. This is especially relevant for our geriatric institutions and nursing homes. A major potential contributing factor for elderly is due to their high incidence of malnutrition: up to 80% among the hospitalized elderly. Malnutrition results when adequate macronutrients and micronutrients are lacking in the diet. Often missing in public health discussions around preventing and treating COVID-19 patients are nutritional strategies to support optimal function of their immune system. This is surprising, given the importance that nutrients play a significant role for immune function. Several micronutrients, such as vitamin D, retinol, vitamin C, selenium and zinc are of special importance supporting both the adaptive and innate immune systems. As suboptimal status or deficiencies in these immune-relevant micronutrients impair immune function and reduces the resistance to infections, micronutrient deficiencies should therefore be corrected as soon as possible, especially in the elderly and other vulnerable groups. According to epidemiological, experimental and observational studies, some case reports and a few intervention studies the supplementation of vitamin D and/or zinc are promising. The multiple anti-inflammatory and immunomodulatory effects of Vitamin D could explain its protective role against immune hyper reaction and cytokine storm in patients with severe COVID-19. A randomized, placebo-controlled intervention study even shows that high dose vitamin D supplementation promotes viral clearance in asymptomatic and mildly symptomatic SARS-CoV-2 positive individuals. Besides, the data of a recent prospective study with COVID-19 patients reveal that a significant number of them were zinc deficient. The zinc deficient patients had more complications and the deficiency was associated with a prolonged hospital stay and increased mortality. Thus, immune-relevant micronutrients may help to increase the physiological resilience against COVID-19.

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Section: Zincmentioning

confidence: 99%

The coronavirus disease (COVID-19) – A supportive approach with selected micronutrients

Gröber¹,

Holick

2022

International Journal for Vitamin and Nutrition Research

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“…The potential for food products, as functional foods or nutraceutical extracts from foods, to alleviate or modify COVID-19 transmission, morbidity or mortality is an especially attractive hypothesis when vaccines are not available. In reviewing the literature, the topic is replete with articles hypothesizing a beneficial effect of a healthy diet in reducing the incidence of COVID-19 infection and depressing its clinical symptoms [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. These articles review past association of a variety of nutritional factors that may influence infections in general and hypothesize that these same associations may modify COVID-19 viral morbidity and mortality.…”

Section: Nutrition As a Strategy For Coronavirus Disease 2019 (Covid-19) Therapymentioning

confidence: 99%

The Impact of Nutrition on the COVID-19 Pandemic and the Impact of the COVID-19 Pandemic on Nutrition

Rodriguez-Leyva

Pierce

2021

Nutrients

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The coronavirus disease 2019 (COVID-19) pandemic has had significant morbidity, mortality, social and financial implications for the global population. Despite this knowledge, we still know very little about how COVID-19 infection affects quality of life resulting from changes in nutritional behaviour and, conversely, how nutrition could modulate the epidemiology of COVID-19. In addition, the social isolation most have experienced due to the regulations imposed by governments during the COVID-19 pandemic may have also had effects on our nutritional behaviour. It is possible that nutritional interventions may have effects on the incidence of COVID-19 infection and mortality rates. The purpose of this review is to evaluate the current status of research on the topic of nutrition as it relates to the COVID-19 pandemic.

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“…Dietary creatine has been recently suggested as a possible adjuvant therapeutic agent for use in COVID-19 recovery [58], due to the beneficial effects demonstrated during rehabilitation in various pulmonary conditions. Being a safe and inexpensive dietary compound, creatine should be investigated post-haste as a possible component of nutritional care for post-COVID-19 fatigue syndrome, along with other nutraceuticals, to reduce post-viral fatigue, promote a swift recovery, and fortify future resistance in often poorly nourished patients [59]. However, like other promising therapeutics for post-COVID-19 subjects, creatine requires accelerated yet attentive research and approval pathways, with sufficient efficacy and safety guarantees.…”

Section: Open Questions and Creatine In The Post-covid-19 Worldmentioning

confidence: 99%

Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome

Ostojić

2021

Nutrients

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Post-viral fatigue syndrome (PVFS) is a widespread chronic neurological disease with no definite etiological factor(s), no actual diagnostic test, and no approved pharmacological treatment, therapy, or cure. Among other features, PVFS could be accompanied by various irregularities in creatine metabolism, perturbing either tissue levels of creatine in the brain, the rates of phosphocreatine resynthesis in the skeletal muscle, or the concentrations of the enzyme creatine kinase in the blood. Furthermore, supplemental creatine and related guanidino compounds appear to impact both patient- and clinician-reported outcomes in syndromes and maladies with chronic fatigue. This paper critically overviews the most common disturbances in creatine metabolism in various PVFS populations, summarizes human trials on dietary creatine and creatine analogs in the syndrome, and discusses new frontiers and open questions for using creatine in a post-COVID-19 world.

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COVID-19 and nutriceutical therapies, especially using zinc to supplement antimicrobials

Cited by 14 publications

References 28 publications

The coronavirus disease (COVID-19) – A supportive approach with selected micronutrients

The coronavirus disease (COVID-19) – A supportive approach with selected micronutrients

The Impact of Nutrition on the COVID-19 Pandemic and the Impact of the COVID-19 Pandemic on Nutrition

Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome

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