COVID-19 and Older Adult

Morley, John E.; Vellas, Bruno

doi:10.1007/s12603-020-1349-9

Cited by 163 publications

(153 citation statements)

References 14 publications

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“…Elder age is a risk factor for COVID-19 severe form [ 114 , 115 ]. Researchers demonstrated mixed results on correlations between aging and TLR4 signaling malfunction; the cytokine production after TLR4 stimulation with LPS increases [ 116 ], decreases [ 117 , 118 ]; and remain unchanged [ 119 ] with aging.…”

Section: Toll-like Receptorsmentioning

confidence: 99%

Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?

Brandão

Ramos

Dompieri

et al. 2021

Cytokine & Growth Factor Reviews

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Highlights Some inflammatory diseases are related to severe forms of COVID-19, characterized by an immune system overactivation. SARS-CoV-2 Spike protein binds with human innate immune receptors, mainly TLR4, increasing secretion of IL‐ 6 and TNF‐ α. The main inflammatory diseases seen as risk factors for COVID-19 are hypertension, diabetes, obesity, and atherosclerosis. The TLR4 signaling pathway is connected to inflammatory diseases seen as risk factors for COVID-19.

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Section: Toll-like Receptorsmentioning

confidence: 99%

Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?

Brandão

Ramos

Dompieri

et al. 2021

Cytokine & Growth Factor Reviews

View full text Add to dashboard Cite

show abstract

“…Old people are constrained from visits with family members, therefore the social participation have been restricted ( 7 ). Thus, the decreasing of social interaction produced by social distancing could have a negative impact on mental and physical health in older people ( 22 – 24 ), since it has limited the social participation in community organizations and in family activities ( 23 , 25 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of Social Isolation Due to COVID-19 on Health in Older People: Mental and Physical Effects and Recommendations

Sepúlveda-Loyola

Rodríguez-Sánchez

Pérez-Rodríguez

et al. 2020

The Journal of nutrition, health and aging

597

352

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Objectives To review the impact of social isolation during COVID-19 pandemic on mental and physical health of older people and the recommendations for patients, caregivers and health professionals. Design Narrative review. Setting Non-institutionalized community-living people. Participants 20.069 individuals from ten descriptive cross-sectional papers. Measurements Articles since 2019 to 2020 published on Pubmed, Scielo and Google Scholar databases with the following MeSh terms (‘COVID-19’, ‘coronavirus’, ‘aging’, ‘older people’, ‘elderly’, ‘social isolation’ and ‘quarantine’) in English, Spanish or Portuguese were included. The studies not including people over 60 were excluded. Guidelines, recommendations, and update documents from different international organizations related to mental and physical activity were also analysed. Results 41 documents have been included in this narrative review, involving a total of 20.069 individuals (58% women), from Asia, Europe and America. 31 articles included recommendations and 10 addressed the impact of social distancing on mental or physical health. The main outcomes reported were anxiety, depression, poor sleep quality and physical inactivity during the isolation period. Cognitive strategies and increasing physical activity levels using apps, online videos, telehealth, are the main international recommendations. Conclusion Mental and physical health in older people are negatively affected during the social distancing for COVID-19. Therefore, a multicomponent program with exercise and psychological strategies are highly recommended for this population during the confinement. Future investigations are necessary in this field.

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“…According to the World Health Organization (WHO) over one million people worldwide are now infected with COVID-19 and over 50,000 deaths have been confirmed so far (updated April 4, 2020) (1). It is now evident that older people are amongst the most vulnerable population with a mortality rate of approximately 15% (2)(3)(4). In addition, people with pre-existing chronic conditions such as diabetes, cardiovascular disease, lung disease, hypertension, and cancer are at increased risk of mortality (2,3,5,6).…”

mentioning

confidence: 99%

“…It is now evident that older people are amongst the most vulnerable population with a mortality rate of approximately 15% (2)(3)(4). In addition, people with pre-existing chronic conditions such as diabetes, cardiovascular disease, lung disease, hypertension, and cancer are at increased risk of mortality (2,3,5,6). Although, the spread of the virus in China, the Republic of Korea and Singapore is mostly under control, other countries like Italy and the United States are facing the tsunami of COVID-19 with a high case fatality rate.…”

mentioning

confidence: 99%

Prevention of COVID-19 in Older Adults: A Brief Guidance from the International Association for Gerontology and Geriatrics (IAGG) Asia/Oceania Region

Chhetri

Chan

Arai

et al. 2020

The Journal of nutrition, health and aging

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COVID-19 and Older Adult

Cited by 163 publications

References 14 publications

Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?

Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?

Impact of Social Isolation Due to COVID-19 on Health in Older People: Mental and Physical Effects and Recommendations

Prevention of COVID-19 in Older Adults: A Brief Guidance from the International Association for Gerontology and Geriatrics (IAGG) Asia/Oceania Region

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