2023
DOI: 10.1111/aji.13700
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COVID‐19 and preeclampsia: The unique and the mutually nonexclusive clinical manifestations

Abstract: Preeclampsia (PE) is a serious, unpredictable hypertensive disorder of pregnancy present in around 8–10% of all pregnancies resulting in high rate of maternal and fetal morbidity and mortality. With the pathophysiology partially known, delivery is the only cure for PE. The disease sets due to multiple pathologic processes involving endothelial cell activation, inflammation, multiorgan damage and syncytiotrophoblast stress.  Though the primary target organ is lungs in COVID‐19, other systemic manifestations whi… Show more

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Cited by 4 publications
(3 citation statements)
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“…The key host protease responsible for initiating this process and facilitating viral entry is TMPRSS2, a type II transmembrane serine protease [ 30 , 31 ]. In addition to ACE2, SARS-CoV-2 impacts other elements of the renin-angiotensin system (RAS), including ADAM17, which primarily controls the levels of ACE2 on the cell membrane and consequently reduces its expression [ 32 ]. ACE2, a membrane-bound exopeptidase primarily found in the kidney, lungs, and heart, is a critical component of the RAS, which regulates the conversion of angiotensin II (Ang II) to angiotensin 1–7 (Ang 1–7) and the conversion of angiotensina I (Ang I) to angiotensina 1–9 (Ang 1–9).…”
Section: Discussionmentioning
confidence: 99%
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“…The key host protease responsible for initiating this process and facilitating viral entry is TMPRSS2, a type II transmembrane serine protease [ 30 , 31 ]. In addition to ACE2, SARS-CoV-2 impacts other elements of the renin-angiotensin system (RAS), including ADAM17, which primarily controls the levels of ACE2 on the cell membrane and consequently reduces its expression [ 32 ]. ACE2, a membrane-bound exopeptidase primarily found in the kidney, lungs, and heart, is a critical component of the RAS, which regulates the conversion of angiotensin II (Ang II) to angiotensin 1–7 (Ang 1–7) and the conversion of angiotensina I (Ang I) to angiotensina 1–9 (Ang 1–9).…”
Section: Discussionmentioning
confidence: 99%
“…In pregnancy, the RAS system plays a crucial role in placental function, controlling trophoblast proliferation, angiogenesis, and blood flow. It significantly influences utero-placental blood flow through the modulation of vasoconstrictor and vasodilator pathways [ 30 , 32 ].…”
Section: Discussionmentioning
confidence: 99%
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