COVID‐19 and skin diseases: results from a survey of 843 patients with atopic dermatitis, psoriasis, vitiligo and chronic urticaria

Criado, Paulo Ricardo; Ianhez, Mayra; Castro, Caio César Silva de; Talhari, Carolina; Ramos, Paulo Müller; Miot, Hélio Amante

doi:10.1111/jdv.17635

Cited by 14 publications

(9 citation statements)

References 11 publications

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“…Conversely, the rate of CU exacerbation in hospitalized patients was higher than in non-hospitalized patients (73% vs. 31%). CU exacerbations have also been reported in a Romanian cohort of CSU patients in whom 44% of infected patients had increased severity of the disease, more frequently seen in moderate–severe COVID infection—47% [ 75 , 78 ]; likewise, high fever was associated with the exacerbation of CU in a Brazilian cohort [ 87 , 90 ]. In the UCARE study, treatments at the time of COVID-19 diagnosis were antihistamines (55.7%), omalizumab (33%), and cyclosporine (2.5%).…”

Section: The Role Of Viral Infections Including Covid-19 In Chronic U...mentioning

confidence: 83%

How Infection and Vaccination Are Linked to Acute and Chronic Urticaria: A Special Focus on COVID-19

Kocatürk

Muñoz

Elieh‐Ali‐Komi

et al. 2023

Viruses

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Since more than a century ago, there has been awareness of the connection between viral infections and the onset and exacerbation of urticaria. Our knowledge about the role of viral infection and vaccination in acute and chronic urticaria improved as a result of the COVID-19 pandemic but it has also highlighted knowledge gaps. Viral infections, especially respiratory tract infections like COVID-19, can trigger the onset of acute urticaria (AU) and the exacerbation of chronic urticaria (CU). Less frequently, vaccination against viruses including SARS-CoV-2 can also lead to new onset urticaria as well as worsening of CU in minority. Here, with a particular focus on COVID-19, we review what is known about the role of viral infections and vaccinations as triggers and causes of acute and chronic urticaria. We also discuss possible mechanistic pathways and outline the unmet needs in our knowledge. Although the underlying mechanisms are not clearly understood, it is believed that viral signals, medications, and stress can activate skin mast cells (MCs). Further studies are needed to fully understand the relevance of viral infections and vaccinations in acute and chronic urticaria and to better clarify causal pathways.

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Section: The Role Of Viral Infections Including Covid-19 In Chronic U...mentioning

confidence: 83%

How Infection and Vaccination Are Linked to Acute and Chronic Urticaria: A Special Focus on COVID-19

Kocatürk

Muñoz

Elieh‐Ali‐Komi

et al. 2023

Viruses

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“…( P = 0.82, P = 0.55) 13 . Moreover, there was no difference in the number of hospitalizations for COVID‐19 between respondents with and without AD according to an online questionnaire ( P = 0.168) 32 . However, some studies have considered AD to be a risk factor for COVID‐19 outcomes.…”

Section: Discussionmentioning

confidence: 96%

“… 13 Moreover, there was no difference in the number of hospitalizations for COVID‐19 between respondents with and without AD according to an online questionnaire ( P = 0.168). 32 However, some studies have considered AD to be a risk factor for COVID‐19 outcomes. An epidemiological study showed that skin diseases, including AD, increase the risk of COVID‐19 (OR, 1.55; P = 1.4 × 10 −9 ).…”

Section: Discussionmentioning

confidence: 99%

No causal association between atopic dermatitis and COVID‐19 outcomes: A Mendelian randomization study

Jin,

2024

Skin Research and Technology

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BackgroundFrequent hand washing and disinfection during the corona virus disease (COVID‐19) pandemic may lead to skin‐related disability. The causal relationship between atopic dermatitis (AD), the most common chronic, noninfectious, inflammatory skin disease, and COVID‐19 remains unclear. We used Mendelian randomization (MR) to explore the causal inference of atopic dermatitis with COVID‐19 outcomes.MethodsGenome‐wide association study (GWAS) data for AD, consisting of 8383 cases and 236,162 controls of European ethnicity, were provided by the FinnGen database. The GWAS outcome data were derived from the COVID‐19 Host Genetics Initiative and consisted of COVID‐19 susceptibility (122,616 cases and 2,475,240 controls), hospitalization (32,519 cases and 2,062,805 controls), and very severe respiratory disease (13,769 cases and 1,072,442 controls). The inverse variance weighted with a fixed effects model (IVW (fe)) was used as the main statistical approach to assess the causality between AD and COVID‐19 in this study. Several other analytical methods have also been used to complement or identify pleiotropy and heterogeneity.ResultsMR analysis showed no causality between AD and COVID‐19 outcomes. The odds ratios (OR) were 1.00 (95% confidence interval (CI), 0.99–1.02) for susceptibility, 1.00 (95% CI, 0.96–1.04) for hospitalization, 0.97 (95% CI, 0.92–1.03) for very severe respiratory disease by the method of IVW (fe).ConclusionIn conclusion, we found no causal relationship between AD and COVID‐19 outcomes. This study provides additional ideas for the exploration of the risk factors for COVID‐19.

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“…Notably, several studies of COVID-19 hospitalization patients have indicated that approximately 39.5% of patients present with different allergic diseases, and the incidence of CU is 10%. Moreover, CU is one of the skin disorders most severely affected by COVID-19, and it severely impairs CU patient care ( 10 , 11 ). Besides, what has caused much concern is the adverse event in which CU occurs secondary to the COVID-19 vaccine ( 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

Integrated bioinformatics to identify potential key biomarkers for COVID-19-related chronic urticaria

Zhang

Feng²,

Zou³

et al. 2022

Front. Immunol.

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BackgroundA lot of studies have revealed that chronic urticaria (CU) is closely linked with COVID-19. However, there is a lack of further study at the gene level. This research is aimed to investigate the molecular mechanism of COVID-19-related CU via bioinformatic ways.MethodsThe RNA expression profile datasets of CU (GSE72540) and COVID-19 (GSE164805) were used for the training data and GSE57178 for the verification data. After recognizing the shared differently expressed genes (DEGs) of COVID-19 and CU, genes enrichment, WGCNA, PPI network, and immune infiltration analyses were performed. In addition, machine learning LASSO regression was employed to identify key genes from hub genes. Finally, the networks, gene-TF-miRNA-lncRNA, and drug-gene, of key genes were constructed, and RNA expression analysis was utilized for verification.ResultsWe recognized 322 shared DEGs, and the functional analyses displayed that they mainly participated in immunomodulation of COVID-19-related CU. 9 hub genes (CD86, FCGR3A, AIF1, CD163, CCL4, TNF, CYBB, MMP9, and CCL3) were explored through the WGCNA and PPI network. Moreover, FCGR3A, TNF, and CCL3 were further identified as key genes via LASSO regression analysis, and the ROC curves confirmed the dependability of their diagnostic value. Furthermore, our results showed that the key genes were significantly associated with the primary infiltration cells of CU and COVID-19, such as mast cells and macrophages M0. In addition, the key gene-TF-miRNA-lncRNA network was constructed, which contained 46 regulation axes. And most lncRNAs of the network were proved to be a significant expression in CU. Finally, the key gene-drug interaction network, including 84 possible therapeutical medicines, was developed, and their protein-protein docking might make this prediction more feasible.ConclusionsTo sum up, FCGR3A, TNF, and CCL3 might be potential biomarkers for COVID-19-related CU, and the common pathways and related molecules we explored in this study might provide new ideas for further mechanistic research.

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COVID‐19 and skin diseases: results from a survey of 843 patients with atopic dermatitis, psoriasis, vitiligo and chronic urticaria

Cited by 14 publications

References 11 publications

How Infection and Vaccination Are Linked to Acute and Chronic Urticaria: A Special Focus on COVID-19

How Infection and Vaccination Are Linked to Acute and Chronic Urticaria: A Special Focus on COVID-19

No causal association between atopic dermatitis and COVID‐19 outcomes: A Mendelian randomization study

Integrated bioinformatics to identify potential key biomarkers for COVID-19-related chronic urticaria

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