The article is devoted to the formation of organizational and economic support of the health care system of Ukraine in the conditions of digitalization. The scientific novelty of the study consists in the development of the theoretical and conceptual foundations of the justification of organizational and economic support for the transformation of the health care system in the digitalization conditions, which involves the use of a comprehensive approach to resource-economic, financial and personnel support, as well as information-digital and organizational-institutional support. This provides an opportunity to obtain a synergistic effect regarding the functioning of the health care system in accordance with the goals and efficiency criteria of the digital transformation, taking into account the consequences of the pandemic and post-war reconstruction. The article describes the problems of transformation of the healthcare system of Ukraine, as well as the priority tasks in the implementation of reforms. The goals of the health care system transformation process can be described by the following characteristics: system efficiency, accessibility of health care services to the population, high quality of services/work in the health care system, high professionalism and appropriate remuneration of the staff involved in all parts of the health care system, and ensuring a high level of social protection of the population. The scheme of organizational and economic support for the digital transformation of the healthcare system in Ukraine includes three key elements: resource and economic, information and digital, and institutional and organizational support. The research made it possible to formulate further goals and criteria for the effectiveness of the digital transformation of the healthcare system, taking into account the consequences of the pandemic and post-war recovery.