In much of the current scientific literature on COVID-19, potential treatments are studied singly or in combination with two or three other items. Treatment options for unvaccinated individuals at high risk for COVID-related complications and mortality have improved but may still be limited for remote locations. A case study of an unvaccinated older male with co-morbidities at higher risk for COVID-19 related mortality is used to illustrate possible solutions to some of the issues. His vital signs, including O 2 saturation, breathing rate, heart rate variability, night skin temperature, and resting heart rate, were monitored for 30 days before and after COVID-19 infection, providing more individual details than available in most studies to date. Supplements may have limited his vulnerability to COVID-19 while monoclonal antibodies led to rapid improvement in multiple vital signs. Tests for COVID-19 may not detect the earliest stages of COVID infection as fever levels increased before the patient tested positive for COVID-19.