COVID-19 and the ethics of human challenge trials

Gordijn, Bert; Have, Henk ten

doi:10.1007/s11019-021-10001-y

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…Furthermore, it is important to note that the outbreak of the COVID-19 pandemic sparked a worldwide discussion regarding ethics, if only because the process of vaccine development, testing, and evaluation progressed very quickly. Questions have also been raised as to whether the outbreak of a pandemic justifies controlled human infection studies and what justification there is for the professional obligation to continue work under circumstances of increased risk ( 64 ). In addition, attention was drawn to the lowered standard of reviewing published research.…”

Section: Discussionmentioning

confidence: 99%

Accessibility to Non-COVID Health Services in the World During the COVID-19 Pandemic: Review

Tuczyńska

Matthews‐Kozanecka

Baum

2021

Front. Public Health

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Background: COVID-19 pandemic caused by SARS-CoV2 has seriously impacted the global economy. Medical facilities around the world were not prepared for the enormous challenges posed by the growing number of patients each day, the shortage of personal protective equipment, and insufficient numbers of medical staff. Governments have tried to counteract the impact of the pandemic, but the measures taken have not always been sufficient to maintain access to and quality of health services at the same level as before the pandemic. The disruption of health services has resulted in more and more research reports from different parts of the world on the accessibility of health services during the COVID-19 pandemic.Methodology: This review article presents 21 selected scientific studies on access to health services in different regions of the world. Articles were found in PubMed, GoogleScholar, Medline, and ScienceDirect databases, then grouped, and significant data were extracted from each article. The results were summarized in a table.Results: The range of limited health services included a variety of specialties, including primary care, psychiatry, orthopedics, cardiology, neurosurgery, and more. Methods used in the studies were based on retrospective analysis or on the subjective assessment of patients in the form of a questionnaire or interview. Most authors claimed a decrease in accessibility to health services during the COVID-19 pandemic compared to the pre-pandemic period, including a decrease in planned surgeries, doctor appointments, patient admission to hospital or ER, and access to medicines. Additionally, some authors observed an increase in the mortality rate. One of the few medical services that have expanded rapidly during the pandemic was online appointments.Conclusions: The COVID-19 pandemic has most certainly affected the accessibility of health services worldwide. Lessons should be learned to prevent inaccessibility to medical services, especially as experts predict another wave of COVID-19 cases.

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Section: Discussionmentioning

confidence: 99%

Accessibility to Non-COVID Health Services in the World During the COVID-19 Pandemic: Review

Tuczyńska

Matthews‐Kozanecka

Baum

2021

Front. Public Health

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“…Considerable literature already addresses questions related to research on the prevention and treatment of Covid-19 itself: informed consent and posttrial access to vaccines for participants in vaccine trials, the permissibility of human challenge trials, and the prioritization and stratification of different Covid-19 studies in the context of limited resources. 8 Bioethicists have also emphasized the importance of ensuring diversity and equity in recruiting individuals to participate in research involving drugs and vaccines for Covid-19. In addition, scholarship has engaged with questions related to resource allocation at the systemic level, and particularly how to balance Covid-related clinical demands, Covid-related research, and other forms of human subjects research.…”

mentioning

confidence: 99%

“…Bioethicists have grappled with a range of challenges raised by the Covid‐19 pandemic. Considerable literature already addresses questions related to research on the prevention and treatment of Covid‐19 itself: informed consent and posttrial access to vaccines for participants in vaccine trials, the permissibility of human challenge trials, and the prioritization and stratification of different Covid‐19 studies in the context of limited resources 8 . Bioethicists have also emphasized the importance of ensuring diversity and equity in recruiting individuals to participate in research involving drugs and vaccines for Covid‐19.…”

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confidence: 99%

Research Ethics during Pandemics: How IRBs Can Prepare

Appel

Wilets

2023

Ethics & Human Research

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The Covid‐19 pandemic has raised a range of complex challenges for the research community in the United States. This essay uses Covid‐19 as a model pandemic illness to consider two such issues that have yet to be fully explored in the ethics literature: first, whether the informed consent process should include a discussion of pandemic risks and, if so, how precisely these risks should be conveyed to potential research participants and, second, whether and under what circumstances vaccination status should be taken into consideration when enrolling subjects in non‐pandemic‐related studies during a pandemic.

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The Case for Human Challenge Trials in COVID-19

Drewett

2023

Bioethical Inquiry

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COVID-19 and the ethics of human challenge trials

Cited by 4 publications

References 3 publications

Accessibility to Non-COVID Health Services in the World During the COVID-19 Pandemic: Review

Accessibility to Non-COVID Health Services in the World During the COVID-19 Pandemic: Review

Research Ethics during Pandemics: How IRBs Can Prepare

The Case for Human Challenge Trials in COVID-19

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