COVID-19 and the liver: What do we know after six months of the pandemic?

Fierro, Nora A.

doi:10.1016/j.aohep.2020.09.001

Cited by 33 publications

(36 citation statements)

References 12 publications

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“…Indeed, a broad spectrum of symptoms associated with COVID-19 has been identified. These range from asymptomatic disease to mild and moderate symptoms and severe symptoms associated with critical illness resulting in acute respiratory distress syndrome, respiratory failure or multiorgan dysfunction, and/or death [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

Atraumatic Splenic Rupture in a SARS-CoV-2 Patient: Case Report and Review of Literature

Agus

Ferrara

Bianco

et al. 2021

Case Reports in Surgery

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Splenic rupture in the absence of trauma or previously diagnosed disease is rare. Due to the delay of diagnosis and treatment, this is a potentially life-threatening condition. We report a case of atraumatic splenic rupture in a SARS-CoV-2 patient. This report is of particular interest as it first identifies SARS-CoV-2 infection as a possible cause of spontaneous rupture of the spleen. A 46-year-old Caucasian woman presented at the emergency department pale and sweaty, complaining of syncopal episodes, tachycardia, hypotension, diarrhea, intense abdominal pain, diffuse arthromyalgia, and fever from the day before. RT-PCR was positive for SARS-CoV-2 infection. CT scan demonstrated extensive hemoperitoneum due to rupture of the splenic capsule. The patient required an emergency open splenectomy because of an unresponsive hemorrhagic shock. At the end of the surgery, the patient was relocated to a COVID-19 dedicated facility. COVID-19 is a new disease of which all manifestations are not yet known. Inpatients affected by SARS-CoV-2 infection with abdominal pain and spontaneous splenic rupture should be considered to avoid a delayed diagnosis.

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Section: Introductionmentioning

confidence: 99%

Atraumatic Splenic Rupture in a SARS-CoV-2 Patient: Case Report and Review of Literature

Agus

Ferrara

Bianco

et al. 2021

Case Reports in Surgery

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“…It has been demonstrated that the extensive release of inflammatory mediators such as TNF- α , IL-6, and IL-10 is associated with increased mortality risk in COVID-19 patients [ 45 ]. Moreover, this cytokine storm may lead to liver dysfunction in these patients as elevated AST/ALT levels are widely reported in the literature [ 46 ]. The potential benefits of β S supplementation in COVID-19 could be investigated in future research.…”

Section: Discussionmentioning

confidence: 99%

β‐Sitosterol Alters the Inflammatory Response in CLP Rat Model of Sepsis by Modulation of NFκB Signaling

Kasirzadeh

Ghahremani

Setayesh

et al. 2021

BioMed Research International

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Purpose. Sepsis originates from the host inflammatory response, especially to bacterial infections, and is considered one of the main causes of death in intensive care units. Various agents have been developed to inhibit mediators of the inflammatory response; one prospective agent is β-sitosterol (βS), a phytosterol with a structure similar to cholesterol. This study is aimed at evaluating the effects of βS on the biomarkers of inflammation and liver function in cecal ligation and puncture- (CLP-) induced septic rats. Methods. Thirty male Wistar rats were divided equally into six groups as follows: sham, CLP, CLP+dexamethasone (DX, 0.2 mg/kg), CLP+βS (1 mg/kg), CLP+imipenem (IMI, 20 mg/kg), and CLP+IMI (20 mg/kg)+βS (1 mg/kg). Serum levels of IL-1β, IL-6, IL-10, AST, ALT, and liver glutathione (GSH) were assessed by ELISA. Liver expression levels of TNF-α and NF-κBi mRNAs were evaluated by RT-qPCR. Results. Serum concentrations of IL-1β, IL-6, IL-10, ALT, and AST and mRNA levels of TNF-α and NF-κBi were all significantly higher in septic rats than in normal rats ( p < 0.05 ). Liver GSH content was markedly lower in the CLP group than that in the sham group. βS-treated rats had remarkably lower levels of IL-1β, IL-6, IL-10, TNF-α, NF-κBi, AST, and ALT (51.79%, 62.63%, 41.46%, 54.35%, 94.37%, 95.30%, 34.87%, and 46.53% lower, respectively) and greater liver GSH content (35.71% greater) compared to the CLP group ( p < 0.05 ). Conclusion. βS may play a protective role in the septic process by mitigating inflammation. This effect is at least partly mediated by inhibition of the NF-κB signaling pathway. Thus, βS can be considered as a supplementary treatment in septic patients.

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“…Кроме того, частота гипербилирубинемии увеличивается в 1,7 раза среди пациентов с COVID-19, которые находятся в критическом состоянии, а косвенные маркеры поражения печени, включая гипоальбуминемию, были обнаружены в семь раз чаще у пациентов с тяжелой формой COVID-19. Безусловно, указанные особенности течения заболевания в стационарных условиях требуют определенной программы реабилитации после курса лечения [399]. Это является основанием для дальнейшего изучения вопроса и включении в консенсус по пост-COVID синдрому результатов не только оценки симптомов поражения печени в острой фазе заболевания, но и в отдаленном периоде [400].…”

Section: клиническая картинаunclassified

Management of patients with digestive diseases during the COVID-19 pandemic. Clinical Practice Guidelines by the Russian scientiﬁc medical society of internal medicine (RSMSIM) and the Gastroenterological Scientiﬁc Society of Russia (2nd edition)

Гриневич

Kravchuk

Педь

et al. 2021

jour

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The presented clinical practice guidelines of the Gastroenterological Scientiﬁc Society of Russia (GSSR), diagnostic, and therapeutic approaches for patients with digestive diseases during the COVID-19 pandemic. The guidelines were approved by the XXIII Congress of the GSSR and the 22nd International Slavonic-Baltic Scientiﬁ c Forum “St. Petersburg - Gastro-2020 ON-LINE” (St. Petersburg, June 11, 2020). The presented clinical practice guidelines of the Russian Scientiﬁc Medical Society of Internal Medicine (RSMSIM) and the Gastroenterological Scientiﬁc Society of Russia (GSSR), diagnostic, and therapeutic approaches for patients with digestive diseases during the COVID-19 pandemic. The recommendations were approved at the XV National Congress of Internal Medicine, XXIII Congress of NOGR on the basis of the 1st edition, adopted at the 22nd International Slavic- Baltic Scientiﬁc Forum “St. Petersburg - Gastro-2020 ON-LINE”.

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COVID-19 and the liver: What do we know after six months of the pandemic?

Cited by 33 publications

References 12 publications

Atraumatic Splenic Rupture in a SARS-CoV-2 Patient: Case Report and Review of Literature

Atraumatic Splenic Rupture in a SARS-CoV-2 Patient: Case Report and Review of Literature

β‐Sitosterol Alters the Inflammatory Response in CLP Rat Model of Sepsis by Modulation of NFκB Signaling

Management of patients with digestive diseases during the COVID-19 pandemic. Clinical Practice Guidelines by the Russian scientiﬁc medical society of internal medicine (RSMSIM) and the Gastroenterological Scientiﬁc Society of Russia (2nd edition)

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