COVID-19 and tuberculosis—threats and opportunities

Zumla, Alimuddin; Marais, Ben J.; McHugh, Timothy D.; Maeurer, Markus; Kapata, Nathan; Ntoumi, Francine; Chanda‐Kapata, Pascalina; Mfinanga, Sayoki; Centis, Rosella; Cirillo, Daniela María; Petersen, Eskild; Hui, David Shu Cheong; Ippolito, Giuseppe; Leung, C C; Migliori, Giovanni Battista; Tiberi, Simon

doi:10.5588/ijtld.20.0387

Cited by 53 publications

(40 citation statements)

References 15 publications

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“…This evidence is consistent with data form other Italian [15][16][17] and regional hospital that have confirmed on a large regional scale the reduction in TB cases in 2020 vs. 2019 (Department of Epidemiology of Lazio Regional Health Service, unpublished data). Also, from the experience of other epidemics, there are possible explanations [10][11][12][13][14][15][16][17][18][19]. The reorganization of hospital/health services under pressure from COVID-19 resulting in the conversion of tuberculosis wards in COVID-19 unit-had a major indirect impact on the path of care of TB patients, explaining the observed reduction in hospitalization.…”

Section: Discussionmentioning

confidence: 99%

Increase in Tuberculosis Diagnostic Delay during First Wave of the COVID-19 Pandemic: Data from an Italian Infectious Disease Referral Hospital

et al. 2021

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Background: The WHO advised that the impact of COVID-19 pandemic on TB services was estimated to be dramatic due to the disruption of TB services. Methods: A retrospective data collection and evaluation was conducted to include all the patients hospitalized for TB at INMI from 9 March to 31 August 2020 (lockdown period and three months thereafter). For the purpose of the study, data from patients hospitalized in the same period of 2019 were also collected. Results: In the period of March–August 2019, 201 patients were hospitalized with a diagnosis of TB, while in the same period of 2020, only 115 patients, with a case reduction of 43%. Patients with weight loss, acute respiratory failure, concurrent extrapulmonary TB, and higher Timika radiographic scores were significantly more frequently hospitalized during 2020 vs. 2019. The median patient delay was 75 days (IQR: 40–100) in 2020 compared to 30 days (IQR: 10–60) in 2019 (p < 0.01). Diagnostic delays in 2020 remain significant in the multiple logistic model (AOR = 6.93, 95%CI: 3.9–12.3). Conclusions: Our experience suggests that COVID-19 pandemic had an impact on TB patient care in terms of higher diagnostic delay, reduction in hospitalization, and a greater severity of clinical presentations.

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Section: Discussionmentioning

confidence: 99%

Increase in Tuberculosis Diagnostic Delay during First Wave of the COVID-19 Pandemic: Data from an Italian Infectious Disease Referral Hospital

et al. 2021

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“…Some projections have been made for these excess deaths, and evidence is already accumulating for some of these excess death causes. 7,8,[15][16][17][18][19][20][21][22][23][24][25] Putting projections together, the excess deaths from the measures taken is likely to be much larger than the COVID-19 deaths, for example, disruption of tuberculosis programmes alone is expected to cause 1.4 million extra deaths over the next 5 years and the death toll from famine can be even more staggering. However, the exact impact of these major problems has very large uncertainty, and some projections may be exaggerated (as was the cause also for COVID-19 projections).…”

Section: Covid-19 Versus From Measures Takenmentioning

confidence: 99%

Global perspective of COVID‐19 epidemiology for a full‐cycle pandemic

Ioannidis

2020

Eur J Clin Investigation

177

162

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Almost a year since the first known cases in November 2019 in Wuhan, COVID-19 has been linked to over 1 million deaths and active epidemic waves continue to spread. It is important to overview the emerging epidemiological footprint and understand the current situation and its implications for the future of the pandemic. It is unknown exactly how long a full cycle for the pandemic spreading worldwide may take, and this is likely to vary across different locations. Regardless,

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“…Furthermore, we do agree that the population of individuals with post-TB treatment sequelae deserves further evaluation, given the potential effect of both TB and COVID-19 on quality of life and subsequent need for rehabilitation [4][5][6].…”

Section: On Tuberculosis and Covid-19 Co-infectionmentioning

confidence: 99%

“…4 Moscow Research and Clinical Center for TB Control, Moscow, Russian Federation. 5 Translational Research Unit, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy. 6 Dipartimento di Scienze Mediche, Clinica Universitaria Malattie Infettive, Ospedale Amedeo di Savoia, Torino, Italia.…”

Section: On Tuberculosis and Covid-19 Co-infectionmentioning

confidence: 99%

The (in)significance of TB and COVID-19 co-infection

Khurana

Aggarwal²

2020

Eur Respir J

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We read with great interest the research letter by TADOLINI et al. [1], in which they have published the first cohort of 49 cases of tuberculosis (TB) and coronavirus disease 20019 (COVID-19) co-infection. However, a few issues regarding the letter need to be addressed. The authors categorised the patients with TB and COVID-19 co-infection into 3 groups based on timing of their diagnosis. However, in view of the difference in the natural history of TB (chronic course) and COVID-19 (acute), categorising 14 patients as having COVID-19 prior to TB (median time interval of 4 days between the two diagnosis) and nine as diagnosed simultaneously (within the same week) seems inappropriate. Since TB has an insidious onset, it is obvious that TB was present before COVID-19 infection in both the subgroups, although the diagnosis was made at different times. In fact, it may be right to say that all the three subgroups actually constitute a single group of old/active TB patients who developed COVID-19 infection. COVID-19 has probably just unmasked some of the subtle active TB cases that were responsible for hidden transmission in the general population [2]. Superimposed COVID-19 has brought them to the hospital to get a timely diagnosis.

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COVID-19 and tuberculosis—threats and opportunities

Cited by 53 publications

References 15 publications

Increase in Tuberculosis Diagnostic Delay during First Wave of the COVID-19 Pandemic: Data from an Italian Infectious Disease Referral Hospital

Increase in Tuberculosis Diagnostic Delay during First Wave of the COVID-19 Pandemic: Data from an Italian Infectious Disease Referral Hospital

Global perspective of COVID‐19 epidemiology for a full‐cycle pandemic

The (in)significance of TB and COVID-19 co-infection

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