COVID-19 Associated Bacteremia with Chryseobacterium indologenes Co-Harboring blaIND-2, blaCIA and blaCcrA

Yeh, Ting-Kuang; Li, Zong-Hao; Huang, Yao‐Ting; Liu, Po‐Yu

doi:10.2147/idr.s347066

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…Hence, it is possible that a GLA exists and whenever there is a lung infection, the possibilities of a gastrointestinal infection rates are higher. Chryseobacterium indologenes was identified in COVID‐19 associated bacteraemia with devastating co‐harbouring antimicrobial resistance genes blaND2, blaCIA and blaCcrA (Yeh and Li 2022 ). In CDIG, apart from C. difficile and E. coli , three other abundant bacteria— R. lactatiformans , Parabacteroides distasonis and F. prausnitzii were frequently associated with gut dysbiosis and severity of gastrointestinal pathologies (Schult and Reitmeier 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of the microbial biomarkers in the gut–lung crosstalk in COVID-19, community-acquired pneumonia and Clostridium difficile infections

Aishwarya

Gunasekaran

2022

Letters in Applied Microbiology

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Respiratory infections are the leading causes of mortality and the current pandemic COVID‐19 is one such trauma that imposed catastrophic devastation to the health and economy of the world. Unravelling the correlations and interplay of the human microbiota in the gut–lung axis would offer incredible solutions to the underlying mystery of the disease progression. The study compared the microbiota profiles of six samples namely healthy gut, healthy lung, COVID‐19 infected gut, COVID‐19 infected lungs, Clostridium difficile infected gut and community‐acquired pneumonia infected lungs. The metagenome data sets were processed, normalized, classified and the rarefaction curves were plotted. The microbial biomarkers for COVID‐19 infections were identified as the abundance of Candida and Escherichia in lungs with Ruminococcus in the gut. Candida and Staphylococcus could play a vital role as putative prognostic biomarkers of community‐acquired pneumonia whereas abundance of Faecalibacterium and Clostridium is associated with the C. difficile infections in gut. A machine learning random forest classifier applied to the data sets efficiently classified the biomarkers. The study offers an extensive and incredible understanding of the existence of gut–lung axis during dysbiosis of two anatomically different organs.

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Section: Discussionmentioning

confidence: 99%

Meta-analysis of the microbial biomarkers in the gut–lung crosstalk in COVID-19, community-acquired pneumonia and Clostridium difficile infections

Aishwarya

Gunasekaran

2022

Letters in Applied Microbiology

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“…Sequencing analysis revealed three β-lactamases including an Ambler Class A Extended-Spectrum β-lactamase, bla CIA , and two metallo-β-lactamases, bla IND-2 and a putative metallo β lactamase (MBL) gene. The bla CIA and bla IND-2 genes code for two predominant β-lactamase genes in C. indologenes and co-harbouring of both has been reported worldwide (Matsumoto et al, 2012;Yeh, Li, Huang, & Liu, 2022;Zhang et al, 2021). The putative MBL is composed of 251 amino acids and has not been characterized before hence was named CIM-1 for C. indologenes metallo-β-lactamase 1 in this study.…”

Section: Origin Of Indologenes #3362mentioning

confidence: 99%

Adding to the family of resistance factors against last resort antibiotics: Identification and characterization of a novel carbapenemase, CIM-1

Wang,

Sapula,

Whittall

et al. 2023

Preprint

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The increasing rate of carbapenem-resistant bacteria within healthcare environments is an issue of great concern that needs urgent attention. This resistance is driven by metallo-β-lactamases (MBLs), which can catalyse the hydrolysis of almost all clinically available β-lactams and are resistant to all the available β-lactamase inhibitors. In this study, a novel MBL was identified in a multidrug resistant isolate of the opportunistic pathogen, Chryseobacterium indologenes. Sequence analysis predicted this MBL (CIM-1) to be a lipoprotein with an atypical lipobox. Characterization of CIM-1 revealed it to be a membrane-associated, high-affinity carbapenemase with a broad spectrum of activity that includes all cephalosporins and carbapenems. This is the first report of the identification and characterisation of an MBL with an atypical lipobox and only the second lipidated MBL to be characterised after critically important NDM-1. We also identified more lipidated MBLs with non-canonical lipoboxes highlighting the necessity in further investigation of lipidated MBLs.

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Identification and characterization of CIM-1, a carbapenemase that adds to the family of resistance factors against last resort antibiotics

Wang,

Sapula,

Whittall

et al. 2024

Commun Biol

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The increasing rate of carbapenem-resistant bacteria within healthcare environments is an issue of great concern that needs urgent attention. This resistance is driven by metallo-β-lactamases (MBLs), which can catalyse the hydrolysis of almost all clinically available β-lactams and are resistant to all the clinically utilized β-lactamase inhibitors. In this study, an uncharacterized MBL is identified in a multidrug resistant isolate of the opportunistic pathogen, Chryseobacterium indologenes. Sequence analysis predicts this MBL (CIM-1) to be a lipoprotein with an atypical lipobox. Characterization of CIM-1 reveals it to be a high-affinity carbapenemase with a broad spectrum of activity that includes all cephalosporins and carbapenems. Results also shown that CIM-1 is potentially a membrane-associated MBL with an uncharacterized lipobox. Using prediction tools, we also identify more potentially lipidated MBLs with non-canonical lipoboxes highlighting the necessity of further investigation of lipidated MBLs.

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COVID-19 Associated Bacteremia with Chryseobacterium indologenes Co-Harboring blaIND-2, blaCIA and blaCcrA

Cited by 4 publications

References 7 publications

Meta-analysis of the microbial biomarkers in the gut–lung crosstalk in COVID-19, community-acquired pneumonia and Clostridium difficile infections

Meta-analysis of the microbial biomarkers in the gut–lung crosstalk in COVID-19, community-acquired pneumonia and Clostridium difficile infections

Adding to the family of resistance factors against last resort antibiotics: Identification and characterization of a novel carbapenemase, CIM-1

Identification and characterization of CIM-1, a carbapenemase that adds to the family of resistance factors against last resort antibiotics

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