COVID‐19 associated Kikuchi‐Fujimoto disease

Stimson, Laura; Stitson, Richard; Bahhadi-Hardo, Maria; Renaudon-Smith, Edward

doi:10.1111/bjh.17292

Cited by 30 publications

(36 citation statements)

References 10 publications

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“…In addition, KFD can occur post or concurrent with COVID-19 infection [15,16]. While the ethnicity of the patients was not specifically mentioned in the available case reports, the patients were young (less than 20 years old), presented with prolonged fever and other systemic symptoms and one case mentioned rapid resolution of the symptoms within 7 days of commencing supportive treatment [15,16]. The clinical course of these cases was similar to that of KFD in general, as well as the cases of KFD post COVID-19 vaccination.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi–Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature

et al. 2021

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With the rapid development of various coronavirus disease 2019 (COVID-19) vaccines in a bid to counter and contain the COVID-19 pandemic, unusual and uncommon side effects of COVID-19 vaccination have been increasingly reported in the literature. Ipsilateral lymphadenopathy is a fairly common side effect of vaccination of any kind, with its etiology most commonly related to reactive lymphadenopathy. However, Kikuchi–Fujimoto Disease (KFD) or necrotizing histiocytic lymphadenitis is rarely observed post-vaccination, with only one other case of KFD post COVID-19 vaccination reported to date. We report two more cases of KFD post COVID-19 vaccination in the Asian population, highlighting the clinical course and salient clinical, radiological and histologic findings. In addition, we provide a literature review of the existing cases of lymphadenopathy post COVID-19 vaccination with cytologic and/or histologic correlation.

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Section: Discussionmentioning

confidence: 99%

Kikuchi–Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature

et al. 2021

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“…The etiopathogenesis of KFD remains unclear; an autoimmune response and diverse infectious agents are the most common hypotheses [ 1 , 2 ]. More recently in the coronavirus disease 2019 (COVID-19) pandemic, few cases of KFD after infection have been reported [ 3 , 4 ]. However, to our knowledge, only four cases of KFD following vaccination against COVID-19 have been described to date [ 5 - 7 ].…”

Section: Introductionmentioning

confidence: 99%

Kikuchi-Fujimoto's Disease or Histiocytic Necrotizing Lymphadenitis Following mRNA COVID-19 Vaccination: A Rare Case

Daghri¹,

Belmoufid²,

Rami³

et al. 2022

Cureus

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Kikuchi-Fujimoto disease (KFD), also known as necrotizing histiocytic lymphadenopathy, is a rare and benign lymph node disorder that mainly occurs in young women. It is clinically characterized by fever with tender and painful cervical lymphadenopathy mostly; however, all areas of lymph nodes can be involved. This disorder is often mistaken for malignant lymphoma or infection. The precise pathophysiology of KFD remains unknown, but it is theorized that it may be post-viral or associated with an autoimmune disease. The diagnosis is based on the histological analysis of the excised involved lymph node. The treatment is mainly supportive with favorable outcomes within a few weeks or months. In this case, we present a 24-year-old woman without a past medical history, who consulted for painful bilateral cervical lymphadenopathy associated with fever that has been evolving for one month following the coronavirus disease 2019 (COVID-19) vaccination. The initial diagnostic workup was performed and the diagnosis of KFD was confirmed based on the histopathological findings of the excised lymphadenopathy. Therapeutic management was based on oral corticosteroid treatment with clinical and radiological improvement after a few days without recurrence during follow-up. This article aims to report a rare case of KFD in a patient after receiving the messenger ribonucleic acid (mRNA)-based COVID-19 vaccine. Therefore, this case highlights the possible association between COVID-19 vaccination and KFD and this should be considered in the differential diagnosis.

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“…9 Reoccurrence has been recorded after a period of 2-10 years of initial presentation. 10 Various atypical presentation or association of KFD has been reported such as high levels of circulating Epstein-Barr viral DNA 11 , lymphocytic meningitis, 12 autoimmune hemolytic anemia, 13 Corona virus disease-19, 14 relapsing polychondritis, 15 acute appendicitis, 16 periportal and retroperitoneal lymphadenopathy, 17 fever of unknown origin, 18 and acute renal failure. 19 The consequence of various nonspecific clinical presentations of KFD is a broader differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Unexplained Fatigue in an Otherwise Healthy Man Linked to Kikuchi-Fujimoto Disease, A Case Report

Pant¹,

Pradhan²,

Sharma

2021

Nep. Med. J.

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Kikuchi histiocytic necrotizing lymphadenitis is a benign and self-limited illness usually characterized by cervical lymphadenopathy and fever. We present a case of a 42-year male who complained of extreme fatigue for 2 weeks. On laboratory workup, he had leucopenia and thrombocytopenia with normal peripheral blood and bone marrow examination. The radiological investigation revealed multiple enlarged lymph nodes in the left axilla and left supraclavicular region. The subsequent excisional biopsy of the axillary node clinched the diagnosis of Kikuchi- Fujimoto disease. The patient was completely recovered and laboratory parameters were normal with supportive treatment. Kikuchi- Fujimoto disease should be considered in patients with unexplained fatigue with lymphadenopathy and early biopsy prevents unnecessary investigations as well as potentially harmful treatments.

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COVID‐19 associated Kikuchi‐Fujimoto disease

Cited by 30 publications

References 10 publications

Kikuchi–Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature

Kikuchi–Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature

Kikuchi-Fujimoto's Disease or Histiocytic Necrotizing Lymphadenitis Following mRNA COVID-19 Vaccination: A Rare Case

Unexplained Fatigue in an Otherwise Healthy Man Linked to Kikuchi-Fujimoto Disease, A Case Report

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