COVID-19-associated mucormycosis in India: Why such an outbreak?

Pasquier, Grégoire

doi:10.1016/j.mycmed.2023.101393

Cited by 12 publications

(4 citation statements)

References 46 publications

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“…In uncontrolled diabetes, ketoacidosis is considered a key factor enabling mucormycosis, with two parallel mechanisms proposed: a low plasma pH reduces the phagocytic effect of macrophages and the oxidative burst of neutrophils, and at the same time, a lower pH reduces the affinity of transferrin for free iron, making metal available to the infecting pathogen [24]. Also, the main comorbidity for mucormycosis in India remained diabetes, as it was found in 54-76% of patients pre-COVID-19 and in 60-92% of patients with COVID-19-associated mucormycosis once the pandemic started [25].…”

Section: Discussionmentioning

confidence: 99%

COVID-19-Associated Rhino-Orbital Mucormycosis: Histological and Electron Microscopy Characteristics

Jeican,

Horhat,

Dumitru

et al. 2024

Diagnostics

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COVID-19-associated rhino-orbital mucormycosis has become a new clinical entity. This study’s aim was to evaluate the histopathological and ultramicroscopic morphological aspects of this fungal infection. This was an observational retrospective study on eight patients from three tertiary centers in Romania. The tissue samples collected during functional endoscopic sinus surgery were studied through histopathological examination, scanning electron microscopy, and transmission electron microscopy. In the histopathological examination, the morphological aspects characteristic of mucormycosis in all cases were identified: wide aseptate hyphae with right-angle ramifications, which invade blood vessels. One case presented perineural invasion into the perineural lymphatics. And in another case, mucormycosis–aspergillosis fungal coinfection was identified. Through scanning electron microscopy, long hyphae on the surface of the mucosa surrounded by cells belonging to the local immune system were identified in all samples, and bacterial biofilms were identified in half of the samples. Through transmission electron microscopy, aseptate hyphae and bacterial elements were identified in the majority of the samples. Rhino-orbital-cerebral mucormycosis associated with COVID-19 produces nasal sinus dysbiosis, which favors the appearance of bacterial biofilms. The way in which the infection develops depends on the interaction of the fungi with cells of the immune system.

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Section: Discussionmentioning

confidence: 99%

COVID-19-Associated Rhino-Orbital Mucormycosis: Histological and Electron Microscopy Characteristics

Jeican,

Horhat,

Dumitru

et al. 2024

Diagnostics

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“…Dies kann zu einer erhöhten Invasionsrate in diesem Bereich führen. Indische Zentren, in denen eine strenge Blutzuckerkontrolle erfolgte und geringe Glukokortikoid-Dosen eingesetzt wurden, berichteten von nur wenigen CAM-Fällen [15].…”

Section: Merkeunclassified

Die Mukormykose in Zeiten von COVID-19: Risiken und Herausforderungen

Seidel,

Sal,

Nacov

et al. 2024

Dtsch Med Wochenschr

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“…Mucormycosis outbreak happened in India during the second COVID-19 wave.It was mainly ROCM type and it affected diabetic patients with uncontrolled Glucose levels and who were on treatment with corticosteroids. 6 We are reporting a case of ROCM successfully treated with antifungal drug and surgery along with a review on the taxonomy, risk factors, pathogenesis, clinical forms, diagnosis and management of mucormycosis.…”

Section: Introductionmentioning

confidence: 99%

A case study of rhino orbito cerebral Mucormycosis (ROCM) in a diabetic patient reported from a multispeciality hospital in Tamil Nadu

John,

Kathirvelu,

et al. 2023

IJMMTD

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ROCM is the most common type of Mucormycosis and it can rapidly spread from the paranasal sinuses to orbit and brain which can be fatal in most patients. Diabetes mellitus is the most common risk factor in India. As invasive fungal diseases present with nonspecific clinical features, increasing awareness and education among clinicians about this deadly enemy is very crucial for early diagnosis and prompt initiation of appropriate therapy. We are reporting a case study on ROCM in a Diabetic patient caused by species along with a short review on the taxonomy, risk factors, pathogenesis, clinical forms, diagnosis and management of mucormycosis. We hope that this will help in expanding awareness among medical community about mucormycosis which is a lethal opponent of patients with Diabetes Mellitus.

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COVID-19-associated mucormycosis in India: Why such an outbreak?

Cited by 12 publications

References 46 publications

COVID-19-Associated Rhino-Orbital Mucormycosis: Histological and Electron Microscopy Characteristics

COVID-19-Associated Rhino-Orbital Mucormycosis: Histological and Electron Microscopy Characteristics

Die Mukormykose in Zeiten von COVID-19: Risiken und Herausforderungen

A case study of rhino orbito cerebral Mucormycosis (ROCM) in a diabetic patient reported from a multispeciality hospital in Tamil Nadu

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