COVID-19 autopsy reports from the Ga-East Municipal and the 37 Military Hospitals in Accra, Ghana

Attoh, Seth; Segborwotso, Roxana P; Akoriyea, Samuel Kaba; Teddy, Gina; Edusei, Lawrence; Hobenu, Frederick; Agyemang-Bediako, Kwasi; Toppar, Alfred; Fatchu, Raymond; Akakpo, Patrick Kafui

doi:10.4314/gmj.v54i4s.9

Cited by 8 publications

(15 citation statements)

References 14 publications

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“…Congested liver was among the common finding described in these studies of, Falasca et al ( 2020 ), Attoh et al ( 2020 ) and Edler et al ( 2020 ). Other than that, steatosis or fatty changes of liver was also one of the frequently found pathology in these studies by Falasca et al ( 2020 ), Menter et al ( 2020 ) and Elsoukkary et al ( 2021 ).…”

Section: Resultsmentioning

confidence: 63%

“…Almost all studies reported on the autopsy pulmonary findings in COVID-19 death except for one article reported by Santoriello et al ( 2020 ) that focused on kidney pathology in COVID-19 deaths. Heavy, firm and edematous lungs have been mostly described in (Roden et al 2021 ; Konopka et al 2020 ; Falasca et al 2020 ; Barton et al 2020 ; Keresztesi et al 2020 ; Attoh et al 2020 ) There was patchy to diffuse consolidation in the lungs as mentioned by (Fig. 2 ).…”

Section: Resultsmentioning

confidence: 78%

“…From the study, nine cases were reported with the presence of myocardial hypertrophy and myocardial fibrosis. Myocardial hypertrophy was one of the common findings of the cardiovascular system described in these studies by (Attoh et al 2020 ; Menter et al 2020 ; Elsoukkary et al 2021 ; McMullen et al 2021 ) In the study of Menter et al ( 2020 ), 70% of the cases have severe generalized atherosclerosis of the aorta.…”

Section: Resultsmentioning

confidence: 87%

“…Influenza case findings : Most cases showed DAD and haemorrhage in respiratory system. COVID-19 autopsy reports from the Ga-East Municipal and the 37 Military Hospitals in Accra, Ghana Attoh et al ( 2020 ) Accra, Ghana Case report 20 cases with comorbidity 65% diabetes mellitus type 2 or hypertension Respiratory system : Macroscopically, lungs were heavy, firm, and severely congested. Microscopically, lungs showed features of DAD.…”

Section: Main Textmentioning

confidence: 99%

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Autopsy findings in COVID-19 infection-related death: a systematic review

Sofizan

Rahman

Lai

et al. 2022

Egypt J Forensic Sci

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Introduction Coronavirus-19 disease (COVID-19) has been declared as pandemic by the World Health Organization (WHO) in March 2020. As of 28 November 2021, there were more than 260 million cases and nearly 5.2 million deaths caused by COVID-19. The most affected system by COVID-19 infection was the respiratory system although several other studies suggested multi-organ involvement with pathophysiology that was not clearly understood. Autopsy findings were beneficial to researchers to determine the mechanism behind these organ failures. The objective of this review was to summarize the autopsy findings related to COVID-19 death. Method Online literature search was conducted via online databases such as Scopus, PubMed and Google Scholar. The keywords inputted during the search were “post-mortem”, “autopsy” and “COVID-19” in title, abstract and keywords. The inclusion criteria were the topic related with the title of this review, published in 2020–2021, have full text available and in English language. Any articles that were not related, duplicated studies, review articles including systematic review and meta-analysis and in other languages were excluded. Results A total of 20 articles were included in this review. The articles reviewed were mostly case reports and case series while others were case-control and cohort study ranging from one to 348 cases. Majority were originated from the United States of America (USA). Conclusion The most frequent system described in autopsy findings in COVID-19 death was the respiratory system, with the most common histological finding of diffuse alveolar damage (DAD). Majority of the findings of other organs were related to chronic diseases.

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Section: Resultsmentioning

confidence: 63%

Section: Resultsmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 87%

Section: Main Textmentioning

confidence: 99%

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Autopsy findings in COVID-19 infection-related death: a systematic review

Sofizan

Rahman

Lai

et al. 2022

Egypt J Forensic Sci

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“…Post-mortem studies have documented a link between aspects of respiratory distress syndrome, such as diffuse alveolar damage and infection with SARS-CoV-2 [ 2 – 4 ]. These studies have, for the most part, focused on geographic areas other than Africa, and thus feature populations with generally lower background rates of various diseases, such as underlying HIV infection and tuberculosis [ 5 , 6 ]; with only single case reports or studies with small number of COVID-19 patients being available from the African continent [ 7 – 10 ]. Furthermore, possible differences in genetics, social behaviours and exposures to other infectious agents in the population may affect the pathology due to SARS-CoV-2 infection.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and histopathology of COVID-19 related deaths in South African adults

et al. 2022

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Comparisons of histopathological features and microbiological findings between decedents with respiratory symptoms due to SARS-CoV-2 infection or other causes, in settings with high prevalence of HIV and Mycobacterium tuberculosis (MTB) infections have not been reported. Deaths associated with a positive ante-mortem SARS-CoV-2 PCR test and/or respiratory disease symptoms at Chris Hani Baragwanath Academic Hospital in Soweto, South Africa from 15th April to 2nd November 2020, during the first wave of the South African COVID-19 epidemic, were investigated. Deceased adult patients had post-mortem minimally-invasive tissue sampling (MITS) performed to investigate for SARS-CoV-2 infection and molecular detection of putative pathogens on blood and lung samples, and histopathology examination of lung, liver and heart tissue. During the study period MITS were done in patients displaying symptoms of respiratory disease including 75 COVID-19-related deaths (COVID+) and 42 non-COVID-19-related deaths (COVID-). The prevalence of HIV-infection was lower in COVID+ (27%) than in the COVID- (64%), MTB detection was also less common among COVID+ (3% vs 13%). Lung histopathology findings showed differences between COVID+ and COVID- in the severity of the morphological appearance of Type-II pneumocytes, alveolar injury and repair initiated by SARS-CoV-2 infection. In the liver necrotising granulomatous inflammation was more common among COVID+. No differences were found in heart analyses. The prevalence of bacterial co-infections was higher in COVID+. Most indicators of respiratory distress syndrome were undifferentiated between COVID+ and COVID- except for Type-II pneumocytes. HIV or MTB infection does not appear in these data to have a meaningful correspondence with COVID-related deaths.

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Findings and inferences from full autopsies, minimally invasive autopsies and biopsy studies in patients who died as a result of COVID19 — A systematic review

Raviraj¹,

Shobhana²

2022

Forensic Sci Med Pathol

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Many articles on COVID19 deaths have been published since the pandemic has occurred. On reviewing the articles published until June 2021, the findings were very heterogeneous. Adding to the existing knowledge, there were also some unique observations made in the pathogenesis of COVID19. This review was done to determine the findings obtained and inferences drawn from various studies published globally among patients who died due to COVID19. PRISMA guidelines were used to conduct this systematic review. A search of databases like PubMed, ScienceDirect and Epistemonikos was done. The articles focusing on postmortem sample studies involving full autopsies, minimally invasive autopsies and tissue biopsy studies were screened and searched. The studies included were all the case reports, case series, narrative reviews and systematic reviews obtained in full text and in the English language containing study information, and samples obtained postmortem. The information obtained was tabulated using Microsoft excel sheets. The duplicates were removed at the beginning of the tabulation. Zotero referencing software was used for article sorting and citation and bibliography. Two authors independently reviewed the articles throughout the process to prevent bias. Adding to the heterogeneity of COVID19, the concept of lethality in preexisting disease conditions, the occurrence of secondary bacterial and fungal infections, and other pathogenetic mechanisms uniquely encountered are to be considered in treating the patients. Also, the presence of SARS-CoV-2 postmortem is established and should be considered a hazard.

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COVID-19 autopsy reports from the Ga-East Municipal and the 37 Military Hospitals in Accra, Ghana

Cited by 8 publications

References 14 publications

Autopsy findings in COVID-19 infection-related death: a systematic review

Autopsy findings in COVID-19 infection-related death: a systematic review

Clinical characteristics and histopathology of COVID-19 related deaths in South African adults

Findings and inferences from full autopsies, minimally invasive autopsies and biopsy studies in patients who died as a result of COVID19 — A systematic review

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