COVID-19 Co-infection in a patient with Crimean Congo Hemorrhagic Fever: A Case Report

Büyüktuna, Seyit Ali; Hasbek, Mürşit; Öksüz, Caner; Baysal, Cihad; Öz, Murtaza; Elaldı, Nazif; Bakır, Mehmet

doi:10.5578/mb.20219813

Cited by 13 publications

(5 citation statements)

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“…Case reports from Turkey and Iran have shown considerable improvement and complete recovery in co-infections of CCHF and Covid if diagnosed early, before multi-organ failure develops. 10 However, in this case the diagnosis of CCHF was delayed until multiorgan failure was already established. Moreover, administration of Baricitinib also raised the suspicion of drug-induced hepatic failure which further delayed the diagnosis of CCHF.…”

Section: Discussionmentioning

confidence: 92%

Case of Covid-19 co-infection with Crimean Congo haemorrhagic fever (CCHF) in a CCHF endemic country: a case report

Musani,

Alam,

Latif

2023

J Pak Med Assoc

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Covid-19 pandemic affected the health care systems globally. In many countries, healthcare services were overwhelmed by the huge number of Covid cases; hence, shifting the focus from locally endemic infectious diseases. Such a case presented to us that was initially managed along the lines of critical Covid pneumonia with steroids, Remdesivir, and supplemental oxygen for hypoxic respiratory failure. The patient also received Baricitinib, to which he was non-responsive and thus offered invasive mechanical ventilation. Post intubation, the patient was managed for Covid-associated ARDS with lung protective ventilation. He later also developed liver dysfunction, renal failure, coagulation derangements, and shock. Workup for malaria and dengue were negative. Later, Crimean Congo PCR was sent which came positive; a possible cause of progressive deterioration. In CCHF endemic areas, it is crucial to rule out the CCHF infection among patients presenting with critical Covid pneumonia due to similar clinical presentation in both the infections.

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Section: Discussionmentioning

confidence: 92%

Case of Covid-19 co-infection with Crimean Congo haemorrhagic fever (CCHF) in a CCHF endemic country: a case report

Musani,

Alam,

Latif

2023

J Pak Med Assoc

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“…The common symptoms observed in COVID-19 patients are highly similar to the symptoms in patients with Crimean-Congo Hemorrhagic Fever (CCHF) (1). There have also been cases of mixed infections of CCHF and COVID-19 during the COVID-19 pandemic (2). Thus, CCHF cases and epidemics are an additional threat to the pandemic coronavirus infection in endemic countries such as Türkiye, Iran, Oman, Russia, and Pakistan.…”

Section: Introductionmentioning

confidence: 82%

An evaluation of the laboratory and clinical data of the Crimean-Congo hemorrhagic fever patients during the Covid-19 pandemic

ÖNER¹,

ÖZGÜLER²

2023

J Exp Clin Med

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In this study, the purpose was to investigate the demographic, laboratory, and clinical characteristics of the Crimean-Congo Hemorrhagic Fever (CCHF) cases that were treated in our hospital during the Coronavirus disease-2019 (COVID-19) pandemic. It was also investigated whether the patients hospitalized with a provisional diagnosis of CCHF who tested negative for CCHF PCR were infected with COVID-19. In our study, data (epidemiological, clinical, laboratory, prognosis) from 38 patients diagnosed with CCHF through reverse-transcriptase polymerase chain reaction (PCR) and viral-RNA and/or Immunoglobulin M antibodies using ELISA between May 2020 and November 2022 were investigated retrospectively. Of all the patients, 23 were CCHF PCR (+) and 15 were CCHF PCR (-).15 (65.2%) of PCR (+) patients and 9 (60%) of PCR (-) patients were engaged in farming. 65.2% of PCR (+) and 26.7% of PCR (-) patients presented with a history of tick bites. 21 (91.3%) of PCR (+) and 12 (80%) of PCR (-) patients had a history of rural living. Among the PCR (+) patients, 65.2%, 17.4%, and 17.4% received treatment for CCHF in 2022, 2021, and 2020 respectively. 87% of PCR (+) and 60% of PCR (-) patients were discharged after full recovery. The most common symptoms were fever, diffuse body ache, weakness, and headache. Significant differences were found between PCR (+) and PCR (-) patients in terms of leukocytes, LDH, INR, NEU, PLT, fibrinogen, and NLR values. 3 patients hospitalized with a provisional diagnosis of CCHF tested negative for CCHF PCR and positive for COVID-19 PCR. Thoracic CT, clinical, and laboratory findings of these patients showed no differences from the other patients. The possibility of misdiagnosis should be considered in CCHF and COVID-19 infections due to their similar symptoms and indications. Extensive multicentric studies need to be conducted to investigate the causes of the increased number of CCHF cases during the pandemic.

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“…This is because both diseases in the early stages have similar symptoms but with different modes of transmission, incubation periods, and mortality rates (11). As a result, diagnosis at some stages can be very difficult, and occasionally, co-infection, leading to ignoring this issue, may occur (11)(12)(13). This study reports the first confirmed but misdiagnosed CCHF case in the setting of an ongoing COVID-19 pandemic from Ravansar County of Kermanshah province in Iran.…”

Section: Introductionmentioning

confidence: 90%

A Case Report of Crimean-Congo Hemorrhagic Fever in Iran

Zeinali,

Doosti,

Amiri

et al. 2023

Arch Clin Infect Dis

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Introduction: Crimean Congo hemorrhagic fever (CCHF) is a tick-borne, zoonotic disease distributed globally. As the clinical features of CCHF and COVID-19 are similar, getting an early and reliable diagnosis may be difficult. Case Presentation: We report the first misdiagnosed case of CCHF in the setting of a COVID-19 pandemic from Ravansar County of Kermanshah province in Iran. Our patient was initially misdiagnosed with COVID-19, got hospitalized, but later tested positive for CCHF. However, the delay in diagnosis caused her death. Conclusions: Crimean Congo hemorrhagic fever should be considered among people in endemic areas who show COVID-19 symptoms for urgent medical attention.

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COVID-19 Co-infection in a patient with Crimean Congo Hemorrhagic Fever: A Case Report

Cited by 13 publications

References 0 publications

Case of Covid-19 co-infection with Crimean Congo haemorrhagic fever (CCHF) in a CCHF endemic country: a case report

Case of Covid-19 co-infection with Crimean Congo haemorrhagic fever (CCHF) in a CCHF endemic country: a case report

An evaluation of the laboratory and clinical data of the Crimean-Congo hemorrhagic fever patients during the Covid-19 pandemic

A Case Report of Crimean-Congo Hemorrhagic Fever in Iran

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