COVID-19, colchicine and glycemia

Ilias, Ιoannis; Milionis, Charalambos

doi:10.1016/j.mehy.2021.110547

Cited by 5 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Critically ill, hospitalised patients with sepsis, hypothermia and organ (hepatic, renal, cardiac and respiratory) failure may develop spontaneous hypoglycaemia (Table 1). Although COVID-19 infection is well known to cause hyperglycaemia both in diabetic and non-diabetic individuals [15], hypoglycaemia has been reported in COVID-19 patients in those admitted to ICU [16] or who received treatment with hydroxychloroquine or colchicine [17,18]. It, therefore, appears COVID-19 is not a cause of hypoglycaemia per se in the absence of severe comorbidity or medication associated with hypoglycaemia.…”

Section: Patients Who Are Illmentioning

confidence: 99%

Investigation and Causes of Spontaneous (Non-Diabetic) Hypoglycaemia in Adults: Pitfalls to Avoid

Elghobashy,

Gama,

Sulaiman

2023

Diagnostics

View full text Add to dashboard Cite

Although adult spontaneous (non-diabetic) hypoglycaemia is rare, its recognition is important for the preventative or curative treatment of the underlying cause. Establishing Whipple’s triad—low blood glucose, neuroglycopaenia and resolution of neuroglycopaenia on increasing blood glucose levels to normal or above—is essential to verify hypoglycaemia. Awareness that hypoglycaemia may occur in severely ill patients is important for its prevention. Further investigation in such cases is unnecessary unless another cause of hypoglycaemia is suspected. Patients are often asymptomatic and normoglycaemic at review. Their history of medication, self-medication, access to hypoglycaemic drugs, alcohol use and comorbidity may provide aetiological clues. The investigation involves obtaining blood samples during symptoms for laboratory glucose measurement or provoking fasting or postprandial hypoglycaemia as directed by symptoms. If confirmed, insulin, c-peptide, proinsulin and beta-hydroxybutyrate are analysed in hypoglycaemic samples. These will classify hypoglycaemia due to non-ketotic hyperinsulinaemia, non-ketotic hypoinsulinaemia and ketotic hypoinsulinaemia, and direct investigations to identify the underlying cause. There are, however, many pitfalls that may mislabel healthy individuals as “hypoglycaemic” or misdiagnose treatable or preventable causes of spontaneous hypoglycaemia. Clinical acumen and appropriate investigations will mostly identify hypoglycaemia and its cause.

show abstract

Section: Patients Who Are Illmentioning

confidence: 99%

Investigation and Causes of Spontaneous (Non-Diabetic) Hypoglycaemia in Adults: Pitfalls to Avoid

Elghobashy,

Gama,

Sulaiman

2023

Diagnostics

View full text Add to dashboard Cite

show abstract

“… 15 , 16 Prevention of GIOP should start as soon as GCS treatment is initiated since bone loss is most rapid in the first months of therapy. 17 Oral bisphosphonates are considered first-line therapy due to their well-proven effectiveness in preventing osteoporosis-related fractures, safety, and the low cost of this regimen. 3 , 18 Despite this, studies still demonstrate that a minority of patients receiving long-term GCS treatment receive bisphosphonates as a preventative measure for GIOP.…”

Section: Introductionmentioning

confidence: 99%

Nationwide prevalence of glucocorticoid prescriptions over 17 years and osteoporosis prevention among long-term users

Bjornsdottir,

Einarsson,

Gröndal

et al. 2024

SAGE Open Medicine

View full text Add to dashboard Cite

Objectives: Glucocorticoid steroids are frequently prescribed, and side effects are well-known, such as glucocorticoid-induced osteoporosis. Our aim was to estimate the nationwide trend in the prevalence of glucocorticoid steroid prescriptions over 17 years and to elucidate the proportion of patients on long-term glucocorticoid steroid therapy who receive active bone protective therapy. As well as to examine which medical specialties prescribe glucocorticoid steroids the most. Methods: This study was a retrospective observational registry study extended over 17 years (2003–2020). Data were retrieved from the Icelandic Prescription Medicine Register on all delivered glucocorticoid steroids (Anatomic therapeutic chemical code: H02AB) for oral use. Long-term users were defined as those who annually received ⩾90 defined daily doses of glucocorticoid steroids. Results: Annually, 3.8% of the population received oral glucocorticoid steroids, from 3.3% in 2006 to 4.3% in 2017. Prednisolone was most frequently prescribed. Females dispatched glucocorticoid steroid prescriptions more often than males (55.8%). Males and females reached their peak prevalence between the ages of 60 and 70. General practitioners most often prescribe glucocorticoid steroids, followed by physicians in training, rheumatologists, internists, and medical students. Of those who received prescriptions for glucocorticoid steroids, 12.2%–18.1% were classified as long-term users. A declining number of patients have been receiving bone-protective therapy in recent years. Only 13.0% of chronic users received bone protective therapy in 2020. Conclusion: The use of glucocorticoid steroids has increased during the last 2 decades despite improvements in treatment for inflammatory disorders. The prevalence of long-term users has remained stable. Meanwhile, the use of parallel active bone-protective therapy among long-term users of glucocorticoid steroids is declining. Thus, improvements in prophylaxis for corticosteroid-induced osteoporosis are urgently needed for patients who require long-term treatment with glucocorticoid steroids.

show abstract

Colchicine in COVID-19 (Mechanism of Action, Effect on Prognosis)

Bytyçi

Banach

2022

Contemporary Cardiology

View full text Add to dashboard Cite

COVID-19, colchicine and glycemia

Cited by 5 publications

References 10 publications

Investigation and Causes of Spontaneous (Non-Diabetic) Hypoglycaemia in Adults: Pitfalls to Avoid

Investigation and Causes of Spontaneous (Non-Diabetic) Hypoglycaemia in Adults: Pitfalls to Avoid

Nationwide prevalence of glucocorticoid prescriptions over 17 years and osteoporosis prevention among long-term users

Colchicine in COVID-19 (Mechanism of Action, Effect on Prognosis)

Contact Info

Product

Resources

About