COVID-19 Disease and Ophthalmology: An Update

Amesty, María; Barrio, Jorge L. Alió del; Alió, Jorge L.

doi:10.1007/s40123-020-00260-y

Cited by 63 publications

(67 citation statements)

References 60 publications

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“…All agree that it is safest to assume that any ophthalmic patient is potentially at risk of having been infected with SARS-CoV-2, especially in regions currently facing significant outbreaks of COVID-19. Overall, the recommended protocols include access control systems with interim guidance for triage, physical distancing measures, frequent and meticulous disinfection of common areas and equipment, the use of slit lamp barriers, or breath shields, a surgical mask for the patient, and personal protective equipment, including eye protection for healthcare personnel [43]. The role of telemedicine during the epidemic is also valuable in diminishing risk.…”

Section: Risk Of Sars-cov-2 Transmission Through Ophthalmic Proceduresmentioning

confidence: 99%

Novel Insights into the Transmission of SARS-CoV-2 Through the Ocular Surface and its Detection in Tears and Conjunctival Secretions: A Review

et al. 2020

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SARS-CoV-2 is a highly transmissible virus that spreads mainly via person-to-person contact through respiratory droplets, or through contact with contaminated objects or surfaces from an infected person. At present we are passing through a phase of slow and painful understanding of the origin, epidemiological profile, clinical spectrum, and risk profile of the virus. To the best of our knowledge there is only limited and contradictory evidence concerning SARS-CoV-2 transmission through other routes. Importantly, the eye may constitute not only a potential site of virus replication but also an alternative transmission route of the virus from the ocular surface to the respiratory and gastrointestinal tract. It is therefore imperative to gain a better insight into the potential ophthalmological transmission route of the virus and establish directions on best practice and future models of care for ophthalmological patients. This review article critically evaluates available evidence on the ophthalmological mode of viral transmission and the value of earlier identification of the virus on the eye. More evidence is urgently needed to better evaluate the need for protective measures and reliable ocular diagnostic tests to diminish further pandemic spread.

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Section: Risk Of Sars-cov-2 Transmission Through Ophthalmic Proceduresmentioning

confidence: 99%

Novel Insights into the Transmission of SARS-CoV-2 Through the Ocular Surface and its Detection in Tears and Conjunctival Secretions: A Review

et al. 2020

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“…Coronaviruses can cause severe ocular disease in animals, including anterior uveitis, retinitis, vasculitis, and optic neuritis in feline and murine species. However, so far, ocular manifestations described in humans were mild and rare (Seah et al 2020;Amesty et al 2020).…”

Section: ; Choi Et Al 2015; Fernandez-cooke Et Al 2019)mentioning

confidence: 99%

COVID-19 ocular findings in paediatric population

Alcalde

Fernández

Moreno

et al. 2020

Preprint

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Purpose To investigate and describe ocular findings in COVID-19 paediatric patients. Methods A total of 17 COVID-19 patients aged between 0 and 17 years old were recruited at the Paediatric Hospital of La Paz University Hospital (Madrid, Spain). A complete ophthalmological examination was performed in all patients. Results Of 17 patients, 50% had a known COVID-19 previous exposure. PCR from nasopharyngeal swabs was positive in 35.29%, whereas IgM and/or IgG serology tests were positive in 81%. Clinical manifestations were: 6 COVID-19associated Paediatric Inflammatory Multisystem Syndrome (PIMS), 7 pneumonias and 2 cutaneous purpura and/or chilblains. Ocular findings were ocular hyperaemia (5 patients), as bilateral acute conjunctivitis (3 patients) or unilateral episcleritis (2 patients). Mean best corrected visual acuity was 1/1 in all tested cases. Only one patient, presenting unilateral optic neuritis, had visual symptoms as unilateral inferior temporal quadrantanopsy. Retinal involvement was found in one patient, where ocular fundus exam showed unilateral retinal vasculitis. Conclusion SARS-CoV-2 infection could produce ocular pathology in children, frequently presented weeks after the acute phase of the disease. We should take into account COVID-19 when performing differential diagnosis of children presenting with conjunctivitis, episcleritis, retinal vasculitis and/or optic neuritis, meanwhile this world-wide pandemic lasts.

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“…According to scholars such as Coroneo and Wu et al (2020), the virus is highly contagious, potentially lethal, with ocular tropism (Coroneo); thus, it may be transmitted through ocular secretions (Wu et al). There are theories, intended to explain this phenomenon, that suggest that the transmission can occur through the inoculation of infected droplets in the ocular conjunctiva (Amesty et al, 2020), causing the further spread of the infection to the respiratory tract due to the anatomical connection between the lacrimal gland and the nasal cavity (Amesty et al). Therefore, an eye spray system could be useful to prevent infection through the eye and, indeed, there is a spray on the market that can reduce the bacterial and viral load on the skin and eyelashes (Seah & Agrawal, 2020).…”

Section: Introductionmentioning

confidence: 99%