COVID-19 disease severity and mortality determinants: A large population-based analysis in Oman

Wahaibi, Adil Al; Rawahi, Bader Al; Patel, Prakash; Khalili, Sulien Al; Maani, Amal Al; Al-Abri, Seif

doi:10.1016/j.tmaid.2020.101923

Cited by 15 publications

(13 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, spleens can persist in SCA patients to adult life where the thalassaemia gene is carried in association with the sickle gene mutation, and the COVID group had a high prevalence of both the alpha and beta thalassemia genes (Alkindi et al, 2010). Fever, cough, fatigue, abdominal pain and anosmia were the lead presenting symptoms in the COVID group (P < 0.5, Chi-Square test), similar to the general population and as reported among sickle cell disease cohorts (Al Wahaibi et al, 2020;Balanchivadze et al, 2020;Khamis et al, 2020). In their report from the same population, Khamis et al (2020) reported that 95.9% of cases were mild, 3.6% moderate and 0.5% severe, with a case fatality rate of 0.5% in the non-SCA population.…”

Section: Discussionsupporting

confidence: 74%

“…The other patient died with COVID-related pneumonia, renal failure and occipital infarction. Both patients had a history of asthma, ACS (2 factors also seen in COVID-19 in the general population) and splenectomy (Al Wahaibi et al, 2020). The COVID group mortality rate is consistent with a French study where COVID-19 mortality among SCA patients was not severe (Arlet et al, 2020); this is thought to be partly due to SCA patients being young and selfisolated, and there may also be a protective effect against COVID-19 driven by cytokine profile (Arlet et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of COVID-19 on vasooclusive crisis in patients with sickle cell anaemia

Elsadek¹,

Al-Madhani²,

Al-Musalhi³

et al. 2021

International Journal of Infectious Diseases

View full text Add to dashboard Cite

Objectives The aim of this study was to assess the impact of COVID-19 on the morbidity and mortality on vasooclusive crisis (VOC) in sickle cell anaemia (SCA) patients. Methods One hundred patients with(fifty) or without COVID-19 PCR positivity(fifty), were enrolled in a prospective cohort study after signing a written informed consent. Results The COVID-19 positive patients had significantly higher median VOC episodes/year i.e 3 /year (IQR, 1-6 /year) v/s 2 /year (IQR, 2-12 /year) (p < 0.05) respectively, however the need for hospitalization was similar. There was a higher culture proven infection in COVID-19 negative group (P = 0.05). COVID-19 positive group had more osteonecrosis (p < 0.05), splenic sequestration, splenomegaly, and hepatic crisis (P values 0.05, 0.006 and 0.02 respectively). Symptoms of fever, cough, fatigue, abdominal pain and anosmia were significantly higher (p < 0.05) in the COVID-19 positive patients. Both cohorts, showed a fall in the mean haemoglobin, lymphocyte subset, platelets, and reticulocytes, whereas, the LDH and ferritin were significantly elevated. In SCA COVID-19 positive patients the rise in WBC, reticulocyte%, platelets, and ferritin was subdued (p < 0.05). Two died in COVID-19 positive, whereas three died in the COVID-19 negative, without statistically significant difference in mortality. Conclusions Although COVID-19 infection may have triggered the onset of VOC, it did not significantly influence the morbidity or mortality in this SCA cohort.

show abstract

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Impact of COVID-19 on vasooclusive crisis in patients with sickle cell anaemia

Elsadek¹,

Al-Madhani²,

Al-Musalhi³

et al. 2021

International Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Although most patients are considered mild cases, severe COVID-19 infection can lead to complications and higher mortality [ 70 ]. In our meta-analysis, severe cases had an approximately 3-fold higher risk of developing ocular symptoms.…”

Section: Discussionmentioning

confidence: 99%

Ocular manifestations in COVID-19 patients: A systematic review and meta-analysis

Zhong

Wang

Zhu

et al. 2021

Travel Medicine and Infectious Disease

View full text Add to dashboard Cite

“…Development in any field can only be achieved by activating the field of scientific research through which decisions are made and reviewed on solid scientific grounds. Examples of research conducted in Oman during the COVID-19 pandemic that aided decision making include a national sero-prevalence survey conducted for COVID-19 disease in the community ( 20 ), a multicenter serological study for health care worker exposure risks and infection ( 21 ), and a large population-based analysis of severity and mortality determinants ( 22 ). Additionally, a pre-campaign cross-sectional knowledge, attitudes, and practices (KAP) study of the COVID-19 vaccine was done ( 23 ).…”

Section: During the Covid-19 Pandemic: Challenges Opportunities And Resiliencementioning

confidence: 99%

Challenges and Opportunities for Public Health Service in Oman From the COVID-19 Pandemic: Learning Lessons for a Better Future

Khalili

Maani

Wahaibi

et al. 2021

Front. Public Health

Self Cite

View full text Add to dashboard Cite

Despite the apparent challenges inflicted by COVID-19 globally, the pandemic provided an opportunity to utilize and expand existing public health capacities for a more adaptive and resilient system during and after each wave of the disease. This paper provides a narrative review of Oman's public health response to the COVID-19 pandemic from January 2020 to July 2021, and the challenges it faced for a more rapid and efficient response. The review demonstrates that the three main pillars influencing the direction of the pandemic and aiding the control are Oman's unified governmental leadership, the move to expand the capacity of the health care system at all levels, and community partnership in all stages of the response including the COVID-19 vaccination campaign. The opportunities identified during response stages in the harmonization of the multisectoral response, streamlining communication channels, addressing vulnerable communities (dormitories, residences at border regions), and providing professional technical leadership provide an excellent precursor for expediting the transformation of Oman's health care system to one with a multisectoral holistic approach. Some of the major challenges faced are the shortage of the public health cadre, lack of a fully integrated digital platform for surveillance, and the scarcity of experts in risk communication and community engagement. A future health system where the center for diseases surveillance and control acts as a nucleus for multisectoral expertise and leadership, which includes community representatives, is crucial to attain optimum health. The destruction inflicted by this prolong COVID-19 pandemic at all levels of human life had valued the importance of investing on preventive and preparedness strategies.

show abstract

COVID-19 disease severity and mortality determinants: A large population-based analysis in Oman

Cited by 15 publications

References 3 publications

Impact of COVID-19 on vasooclusive crisis in patients with sickle cell anaemia

Impact of COVID-19 on vasooclusive crisis in patients with sickle cell anaemia

Ocular manifestations in COVID-19 patients: A systematic review and meta-analysis

Challenges and Opportunities for Public Health Service in Oman From the COVID-19 Pandemic: Learning Lessons for a Better Future

Contact Info

Product

Resources

About