COVID-19 en pacientes en hemodiálisis en Colombia: reporte de siete casos

Aroca, Gustavo; Vélez-Verbel, María; Cadena, Andrés; Avendaño, Lil; Hernández, Sandra; Sierra, Angélica; Cabarcas, Omar; Depine, Santos Ángel

doi:10.7705/biomedica.5743

Cited by 2 publications

(3 citation statements)

References 35 publications

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“…In our study, cough, dyspnea, and fever were frequent symptoms, which is in line with what has been previously reported in CKD patients (cough in 35-69%, dyspnea in 6.25-57%, and fever in 43-71%) 3 , 13 , 20 - 24 , with the exception of the ERACODA series that documented considerably lower incidences (cough in 9.55%, dyspnea in 6.65%, and fever in 11%). This could be explained by the inclusion of CKD patients followed and treated as outpatients and, therefore, more likely to be asymptomatic.…”

Section: Discussionsupporting

confidence: 93%

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Presentation and outcomes of chronic kidney disease patients with COVID-19

et al. 2022

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Introduction: COVID-19 is currently a global health issue and an important cause of mortality. Chronic kidney disease (CKD) is one of the risk factors for infection, morbidity and mortality by SARS-CoV-2. In our study, we aimed to evaluate the clinical presentation and outcomes of CKD patients with COVID-19, as well as identify predictors of mortality. Methods: This was a retrospective study of CKD patients admitted in a tertiary-care Portuguese hospital between March and August of 2020. Variables were submitted to univariate and multivariate analysis to determine factors predictive of in-hospital mortality. Results: 130 CKD patients were analyzed (median age 73.9 years, male 60.0%). Hypertension (81.5%), cardiovascular disease (36.2%), and diabetes (54.6%) were frequent conditions. Cough, dyspnea, fever and respiratory failure were also common. Almost 60% had anemia, 50% hypoalbuminemia, 13.8% hyperlactacidemia and 17% acidemia. Mean serum ferritin was 1531 µg/L, mean CRP 8.3 mg/dL and mean LDH 336.9 U/L. Most patients were treated with lopinavir/ritonavir, hydroxychloroquine or corticosteroids and only 2 with remdesivir. Eighty percent had acute kidney injury and 16.2% required intensive care unit admission. The 34 patients who died were older and more likely to have heart failure. They had higher neutrophils/lymphocytes ratio, ferritin, lactate, and LDH levels. Multivariate analysis identified an association between older age [OR 1.1 (CI 1.01-1.24), p=0.027], higher ferritin [OR 1.0 (CI 1.00-1.00), p=0.009] and higher LDH levels [OR 1.0 (CI 1.00-1.01), p=0.014] and mortality. Conclusion: In our cohort of CKD patients with COVID-19, older age, higher ferritin, and higher LDH levels were independent risk factors for mortality.

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Section: Discussionsupporting

confidence: 93%

“…This might indicate a worse nutritional status of our cohort. As expected, inflammation markers (ferritin and CRP) and LDH were elevated 3 , 4 , 9 , 20 , 22 - 24 , 26 , 29 .…”

Section: Discussionsupporting

confidence: 80%

Presentation and outcomes of chronic kidney disease patients with COVID-19

et al. 2022

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“…Dentre os estudos com pacientes em hemodiálise, estudo na Colômbia encontrou como sintomas mais frequentes febre, tosse e dispneia. 25 Um estudo na Coreia do Sul encontrou como sintomas mais comuns os sintomas respiratórios, como tosse, produção de expectoração e dispneia. 26 Em um estudo em Wuhan, China, os sintomas mais comuns foram febre, fadiga, tosse, expectoração, dispneia, náusea/vômito, diarreia e dor de garganta.…”

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Infecção por COVID-19 em pacientes da lista de espera para transplante renal

et al. 2022

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Objetivo: Identificar aspectos sociodemográficos e clínicos da infecção por COVID-19 em pacientes da lista de espera para transplante renal. Material e métodos: Estudo descritivo, observacional, transversal, realizado com 46 pacientes com COVID-19 (93,8% dos pacientes com teste positivo), acompanhados no ambulatório de transplante renal de um hospital universitário em Fortaleza – CE . A coleta foi realizada em dezembro de 2020 por prontuários e entrevista semiestruturada e análise pelo programa Statistical Package for the Social Sciences (SPSS). Resultados: A maioria apresentou hipertensão (72%) e diabetes (26%). A transmissão mais frequente foi a nosocomial (63%). O modo de diagnóstico predominante foi o RT-PCR (46%). Os sintomas foram: febre (65%), anosmia (64%), digeusia (57%), adinamia (50%), tosse seca (46%), inapetência (43%), dispneia (39%) e mialgia (39%). O monitoramento mais frequente foi o domiciliar (63%), seguido do internamento em enfermaria (30%) e internamento em UTI (7%). O tempo médio de internação foi de 9,11 dias. A maior idade se mostrou significativamente associada ao aumento de dias de internamento. Quanto ao desfecho, 93% tiveram cura e 7% foram a óbito. Conclusão: Os resultados demonstraram semelhança do perfil sociodemográfico e clínico em comparação com os dados da população em diálise. Contudo, a mortalidade encontrada foi maior que a demonstrada na população geral.

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COVID-19 en pacientes en hemodiálisis en Colombia: reporte de siete casos

Cited by 2 publications

References 35 publications

Presentation and outcomes of chronic kidney disease patients with COVID-19

Presentation and outcomes of chronic kidney disease patients with COVID-19

Infecção por COVID-19 em pacientes da lista de espera para transplante renal

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