COVID-19 Hastaları İçin Prognostik Faktörler ve Eozinofillerin Rolü

Abstract

Objective:We planned to investigate the relationship of blood eosinophil level with disease severity and its effect on prognosis in coronavirus disease 2019 (COVID-19) patients.Material and Methods: Four hundred and thirty-four COVID-19 patients who were hospitalized in the ward and admitted to our hospital between March 11, 2020, and May 15, 2020, and whose diagnosis was confirmed by real-time-polimerase chain reaction were included in the study.Results: Lymphocyte, eosinophil count, and percentage were found to be significantly lower in mortal group (p=0.004, p=0.043, p<0.001, respectively). The blood c-reactive protein (CRP) value was also found to be high in mortal group (p<0.001). When the radiological findings accompanied by pleural effusion were more fatal (p<0.001). In addition, significantly more lobe involvement (mean 4.5) was observed in mortal group (p=0.009). According to the results of multivariate logistic regression analysis, 50-64 age range (p=0.028), shortness of breath (p=0.011), complaints of nauseavomiting (p=0.007), low number and percentage of eosinophils in the blood count (p=0.001), and radiological findings accompanied by pleural effusion (p=0.026) were determined as important risk factors for mortality. Conclusion:The presence of eosinopenia and elevated CRP with lymphopenia at admission in COVID-19 patients is an indicator of poor prognosis and has been found to be associated with mortality.