COVID‐19 hospitalization with later long COVID in a person with Down syndrome

Abstract

Viruses that induce pulmonary difficulties and auto-inflammation are more common in people with Down syndrome. They also have a higher number of comorbidities associated with a worse prognosis than the overall population.Adult patients with acute COVID-19 are increasingly being diagnosed with Long COVID. However, patients with Down syndrome with later long COVID-19 are the first example documented in Bangladesh.

Enhancing understanding of SARS-CoV-2 infection among individuals with Down syndrome: An integrative review

“…Hypothyroidism was persistent; 7 , 19 , 24 , 32 , 35 , 38 , 39 Malle et al 19 demonstrated a 50% prevalence among patients with DS hospitalized due to COVID-19. Despite this, thyroid disease did not appear to have played a direct role in the progression of COVID-19.…”

“…However, it is known that the coronavirus family, in general, has developed strategies to evade the effects of IFN, which probably also occurred with SARS-CoV-2. 32 , 51 , 68 …”

“…As chromosome 21 encodes four of the six types of interferon receptors, an extra copy of this chromosome can result in higher plasma levels of interferons. 32 , 50 …”

“…22,24,36,40,42 Apnea has been linked to a more severe course of COVID-19, ventilatory support, prolonged hospitalization, and death. 24,36,42 Hypothyroidism was persistent; 7,19,24,32,35,38,39 Malle et al 19 demonstrated a 50% prevalence among patients with DS hospitalized due to COVID-19. Despite this, thyroid disease did not appear to have played a direct role in the progression of COVID-19.…”

“…or post-COVID conditions. 32,50 The risk of mortality was also higher. 21,56,59,61,63,64 In the cohort study by Semenzato et al, 56 27,30,35,39,41,44,51,[65][66][67] Individuals with DS tended to have a higher early initial response to infection, especially through the action of IFNs, which could theoretically contain the viral spread.…”