COVID-19 in Children

Kalyanaraman, Meena; Anderson, Michael R.

doi:10.1016/j.pcl.2022.01.013

Cited by 19 publications

(21 citation statements)

References 80 publications

(99 reference statements)

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“…Knowing the general effects of hyperbaric oxygen therapy including the alleviation of general inflammation by reducing the expression of TLR2 and TLR4 receptors and polarizing cytokine-secreting macrophages (and thus preventing acute respiratory failure), reducing fatigue and improving cognitive abilities, reducing tissue edema and improving tissue oxygenation, and antimicrobial activity [ 14 , 32 , 33 ], it can be expected that its effect will also be positive in the treatment of children with the pediatric inflammatory multisystem syndrome (PIMS, MIS-C) developed as a complication of COVID-19, and the treatment of other complications such as pediatric acute respiratory distress syndrome (PARDS). Both the occurrence of MIS-C and PARDS are likely to be initiated by the secretion of large amounts of pro-inflammatory cytokines and lead to multi-organ dysfunction [ 9 ]. Therefore, it can be speculated that hyperbaric oxygen therapy could potentially be used to treat pediatric patients with COVID-19 to prevent the development of pediatric acute respiratory failure and pediatric inflammatory multisystem syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Statistics show that children account for about 2–13% of all COVID-19 patients in individual countries, but this figure may be a significant underestimate due to the small number of tests among the youngest [ 4 , 5 , 6 , 7 , 8 ]. However, t in the most severe cases, children also develop acute respiratory failure, which is characterized by a reduced ratio of the partial pressure of oxygen to the fraction of inspired oxygen and reduced blood oxygen saturation [ 9 ]. However, a much bigger problem in the youngest population is complications after COVID-19, mainly involving pediatric inflammatory multisystem syndrome (PIMS, MIS-C) [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, t in the most severe cases, children also develop acute respiratory failure, which is characterized by a reduced ratio of the partial pressure of oxygen to the fraction of inspired oxygen and reduced blood oxygen saturation [ 9 ]. However, a much bigger problem in the youngest population is complications after COVID-19, mainly involving pediatric inflammatory multisystem syndrome (PIMS, MIS-C) [ 9 , 10 , 11 ]. The characteristic feature of PIMS is generalized multisystem inflammation with co-morbid fever, skin and mucosal lesions, and cardiopulmonary and gastrointestinal symptoms appearing several weeks after infection [ 9 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, a much bigger problem in the youngest population is complications after COVID-19, mainly involving pediatric inflammatory multisystem syndrome (PIMS, MIS-C) [ 9 , 10 , 11 ]. The characteristic feature of PIMS is generalized multisystem inflammation with co-morbid fever, skin and mucosal lesions, and cardiopulmonary and gastrointestinal symptoms appearing several weeks after infection [ 9 , 11 ]. PIMS can also lead to the development of complications such as shock, coronary artery aneurysms, and acute myocarditis, which is often confirmed by echocardiographic abnormalities [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Can Hyperbaric Oxygen Therapy Be Used to Treat Children after COVID-19? A Bibliographic Review

Myśliwiec¹,

Walatek²,

Tarnawa³

et al. 2022

IJERPH

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The coronavirus disease (COVID-19) epidemic is a public health emergency of international concern. It was believed that SARS-CoV-2 virus was much less likely affect children. Statistics show that children account for 2–13% of all COVID-19 patients in individual countries. In the youngest population, acute respiratory failure is not as serious a problem as complications after COVID-19, mainly pediatric inflammatory multisystem syndrome (PIMS, MIS-C). This study used a bibliography review. The Medline database (using the PubMed platform) and the Cochrane Clinical Trials database were searched using the following keywords: hyperbaric oxygen therapy for children, treatment of children with COVID-19, and use of HBOT in the treatment of children following COVID-19. Thirteen publications that quantitatively and qualitatively described the efficacy of HBOT application in the treatment of pediatric diseases were eligible among the studies; those relating to the use of HBOT in the treatment of children with COVID-19 and its complications were not found. The bibliographic review showed that hyperbaric oxygen therapy can be used in the treatment of children after carbon monoxide poisoning, with soft tissue necrosis, bone necrosis, after burns, or after skin transplant. No evidence supported by research has been found in scientific journals on the effectiveness of the use of hyperbaric oxygen therapy in children with a history of COVID-19 infection. Research data are needed to develop evidence-driven strategies with regard to the use of HBOT therapy in the treatment of children and to reduce the number of pediatric patients suffering because of complications after COVID-19.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Can Hyperbaric Oxygen Therapy Be Used to Treat Children after COVID-19? A Bibliographic Review

Myśliwiec¹,

Walatek²,

Tarnawa³

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…Cardiac, cardiorespiratory, and gastrointestinal complications are the most common reasons for admission to intensive care units, indicating the severity of this condition. 12 …”

Section: The Direct Impact Of Covid-19 On the Health Of Children And ...mentioning

confidence: 99%

COVID-19 vaccination in children: a public health priority

Lima

Leite

2023

Jornal de Pediatria

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COVID‐19 and pediatric pulmonology: Feedback from an expert center after the first year of the pandemic

Corvol

Prévost

Aubertin

et al. 2022

Pediatric Pulmonology

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The coronavirus disease 2019 (COVID‐19) outbreak has evolved with different waves corresponding to subsequent severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) mutations. While the most severe cases have been observed in the elderly and in individuals with underlying comorbidities, severe pediatric and young adult cases have been observed, as well as post‐infectious inflammatory syndromes and persistent symptoms leading to long‐COVID. This manuscript describes the experience of a pediatric respiratory unit during the first year of the pandemic and reviews the corresponding literature with a special emphasis on children and young people with underlying conditions, such as immunosuppression, sickle cell disease, and cystic fibrosis.

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COVID-19 in Children

Cited by 19 publications

References 80 publications

Can Hyperbaric Oxygen Therapy Be Used to Treat Children after COVID-19? A Bibliographic Review

Can Hyperbaric Oxygen Therapy Be Used to Treat Children after COVID-19? A Bibliographic Review

COVID-19 vaccination in children: a public health priority

COVID‐19 and pediatric pulmonology: Feedback from an expert center after the first year of the pandemic

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