COVID-19 in dialysis units: A comprehensive review

Nogueira, Gabriel Martins; Oliveira, Moisés Santana; Moura, Ana Flávia; Cruz, Constança Margarida Sampaio; Moura-Neto, José A.

doi:10.5501/wjv.v10.i5.264

Cited by 6 publications

(3 citation statements)

References 63 publications

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“…Additional strategies to minimize infection were implemented internationally, including reduced visitor access in hospitals 98 , 99 and dialysis units 100 . End-of-life care provision was dramatically altered because of the restrictions, with limitations of social contact and rituals before and after death 101 .…”

Section: Psychosocial Aspects Of Covid-19mentioning

confidence: 99%

Impact of the COVID-19 pandemic on the kidney community: lessons learned and future directions

et al. 2022

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The coronavirus disease 2019 (COVID-19) pandemic has disproportionately affected patients with kidney disease, causing significant challenges in disease management, kidney research and trainee education. For patients, increased infection risk and disease severity, often complicated by acute kidney injury, have contributed to high mortality. Clinicians were faced with high clinical demands, resource shortages and novel ethical dilemmas in providing patient care. In this review, we address the impact of COVID-19 on the entire spectrum of kidney care, including acute kidney injury, chronic kidney disease, dialysis and transplantation, trainee education, disparities in health care, changes in health care policies, moral distress and the patient perspective. Based on current evidence, we provide a framework for the management and support of patients with kidney disease, infection mitigation strategies, resource allocation and support systems for the nephrology workforce.

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Section: Psychosocial Aspects Of Covid-19mentioning

confidence: 99%

Impact of the COVID-19 pandemic on the kidney community: lessons learned and future directions

et al. 2022

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“…Pre-existing conditions such as cardiovascular disease, diabetes mellitus (DM), hypertension (HT), and chronic kidney disease (CKD) have been identified as significant risk factors for severe disease and mortality [ 11 , 12 , 13 , 14 , 15 , 16 ]. The emergence of the COVID-19 pandemic has brought forth unprecedented challenges for individuals on a global level, but for those undergoing hemodialysis, the impact has been particularly pronounced [ 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

A Study on Mortality Predictors in Hemodialysis Patients Infected with COVID-19: Impact of Vaccination Status

Brkovic,

Nikolic,

Baralic

et al. 2023

Vaccines

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The global outbreak of COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted significant public health concerns. This study focuses on 442 chronic hemodialysis patients diagnosed with COVID-19, emphasizing the impact of vaccination status on clinical outcomes. The study investigates the correlation between vaccination status and laboratory findings, aiming to identify predictive factors for mortality. Results indicate that vaccination status plays a crucial role in outcomes. Full vaccination, evidenced by two or three doses, is associated with better outcomes, including reduced incidence of bilateral pneumonia and lower risks of complications such as hemorrhage and thrombosis. Laboratory analyses reveal significant differences between vaccinated and unvaccinated patients in parameters like C-reactive protein, ferritin, and white blood cell counts. Univariate and multivariate Cox proportional hazards regression analyses identify several factors influencing mortality, including comorbidities, pneumonia development, and various inflammatory markers. In conclusion among hemodialysis patients affected by COVID-19 infection, vaccination with at least three doses emerges as a protective factor against fatal outcomes. Independent predictors of mortality are CRP levels upon admission, maximum CRP values during the illness and cardiovascular comorbidities. Noteworthy lymphocytopenia during infection exhibits a notable level of specificity and sensitivity in predicting mortality.

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“…Moreover, the reported SARS-CoV-2 seroprevalence is up to 40% in patients on dialysis, even in the presence of the asymptomatic disease [ 5 ]. The elevated infectious risk in these patients can be partly explained by the need for repeated access to hospital/health care facilities, transport from home to the dialysis center and prolonged treatment in contact with other patients and staff [ 6 , 7 ]. The common presence of cardiovascular comorbidity, overweight, diabetes, associated with inflammation, accelerated immunosenescence and ultimately age-related immune dysfunction is another underlying cause for the unfavorable outcomes [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of SARS-CoV-2 Vaccination in Dialysis Patients: Epidemiological Analysis and Evaluation of the Clinical Progress

Mosconi

Fantini

Righini³

et al. 2022

JCM

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This study investigated the impact of the fourth COVID-19 pandemic wave on dialysis patients of Romagna territory, assessing the associations of vaccination status with infection risk, clinical severity and mortality. From November 2021 to February 2022, an epidemiological search was conducted on 829 patients under dialysis treatment for at least one month. The data were then analyzed with reference to the general population of the same area. A temporal comparison was also carried out with the previous pandemic waves (from March 2020 to October 2021). The epidemiological evolution over time in the dialysis population and in Romagna citizens replicated the global trend, as the peak of the fourth wave corresponded to the time of maximum diffusion of omicron variant (B.1.1.529). Of 771 prevalent dialysis patients at the beginning of the study, 109 (14.1%) contracted SARS-CoV-2 infection during the 4-month observation period. Vaccine adherence in the dialysis population of the reference area was above 95%. Compared to fully or partially vaccinated subjects, the unvaccinated ones showed a significantly higher proportion of infections (12.5% vs. 27.0% p = 0.0341), a more frequent need for hospitalization (22.2% vs. 50.0%) and a 3.3-fold increased mortality risk. These findings confirm the effectiveness of COVID-19 vaccines in keeping infectious risk under control and ameliorating clinical outcomes in immunocompromised patients.

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COVID-19 in dialysis units: A comprehensive review

Cited by 6 publications

References 63 publications

Impact of the COVID-19 pandemic on the kidney community: lessons learned and future directions

Impact of the COVID-19 pandemic on the kidney community: lessons learned and future directions

A Study on Mortality Predictors in Hemodialysis Patients Infected with COVID-19: Impact of Vaccination Status

Efficacy of SARS-CoV-2 Vaccination in Dialysis Patients: Epidemiological Analysis and Evaluation of the Clinical Progress

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