COVID-19 in Grade 4–5 Chronic Kidney Disease Patients

Collado, Sílvia; Arenas, María Dolores; Barbosa, Francesc; Cao, Higini; Montero, María Milagro; Villar-García, Judit; Barrios, Clara; Rodríguez, Eva; Sans, Laia; Sierra, Adriana; Pérez‐Sáez, María José; Redondo-Pachón, Dolores; Coca, Armando; Maiques, José María; Güerri‐Fernández, Robert; Horcajada, Juan Pablo; Crespo, Marta; Pascual, Julio

doi:10.1159/000511082

Cited by 19 publications

(18 citation statements)

References 12 publications

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“… 14 A study by Collado et al showed that COVID‐19 infected patients with advanced CKD with or without AKI had a tendency to present with more respiratory symptoms like cough and dyspnoea. 10 This was similar to our findings. The prevalence of cardiovascular disease among patients with KD could worsen fluid overload and lead to exacerbation of respiratory symptoms.…”

Section: Discussionsupporting

confidence: 93%

“…ERA‐EDTA council and ERACODA working group highlighted that dialysis (3.7×), organ transplant (3.5×) and advanced CKD (2.5×) were three of the top four risk factors associated with COVID‐19 deaths 14 . A study by Collado et al showed that COVID‐19 infected patients with advanced CKD with or without AKI had a tendency to present with more respiratory symptoms like cough and dyspnoea 10 . This was similar to our findings.…”

Section: Discussionsupporting

confidence: 91%

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COVID‐19 death and kidney disease in a multiracial Asian country

Goh

Shanmuganathan

Peariasamy³

et al. 2022

Nephrology

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Introduction COVID‐19 infection and kidney disease (KD) carry a considerable risk of mortality. Understanding predictors of death and KD may help improve management and patient outcome. Methods This is a prospective multicentre observational study conducted in a multiracial Asian country to identify predictors of death and acute kidney injury (AKI) in hospitalized COVID‐19 patients from January to June 2020. Results A total of 6078 patients were included in this study. Mean age was 37.3 (±16.8) years, 71% were male, 59.4% Malay, 6.7% Chinese, 2.3% Indian and 31.7% other ethnicities. AKI was seen in 3.5% of patients while 1.6% had pre‐existing chronic kidney disease (CKD). Overall case fatality rate (CFR) was 1.3%. Patients with KD (AKI and CKD) had CFR of 20%. Many factors were associated with increased risk of death and AKI. However, significant predictors of death after adjustment for covariates were age (>70 years), Chinese ethnicity, diabetes mellitus (DM) and KD. Adjusted predictors of AKI were age (>51 years), DM and severity at presentation. Chinese were 2.58 times more likely to die ( p = .036) compared to Malay. Centre capacity to manage, ventilate and dialyze patients significantly influenced death. Among those with AKI, the most common symptoms were fever, cough, and dyspnea. They had lower absolute lymphocyte count, were more likely to be admitted to ICU, required more ventilation and longer hospitalization. Conclusion Patient and centre factors influence death and AKI among COVID‐19 patients. This study also demonstrates death disparities across different racial groups and centre capacities in this multiracial Asian country.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

COVID‐19 death and kidney disease in a multiracial Asian country

Goh

Shanmuganathan

Peariasamy³

et al. 2022

Nephrology

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“…Collado et al . [ 19 ] presented a case series with seven patients suffering from CKD in which the Estimated Glomerular filtration rate (eGFR) was between 12 and 20 mL/min during the month prior to the COVID-19/SARS-COV-2 infection. The three major symptoms were fever, cough and dyspnoea, and five patients showed bilateral pneumonia.…”

Section: Discussionmentioning

confidence: 99%

Impact of age, gender and comorbidities affecting the severity of COVID-19 infection in Kashmir

Hamza

Shah

Azad

et al. 2022

Journal of Family Medicine and Primary Care

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Aim: To study the impact of age, gender and comorbidities/risk factors affecting the severity of CoronaVirus Disease 2019/Severe acute respiratory syndrome coronavirus 2 (COVID-19/SARS-COV-2) infection in the Kashmiri community. Materials and Methods: The present descriptive cross-sectional study was conducted in the Chest Disease Hospital. The study included 957 subjects who were diagnosed with SARS-CoV-2 infection. Descriptive statistics were calculated. Results: In the age group <40 years, the severity of illness was found to be 30.42% and the occurrence of death was 11.54%, in the 40–60 years, the severity of the illness was found to be 32.51% and the occurrence of death was 12.84%, in the older age >60 years, the severity of illness was found to be 35.74% and the occurrence of death was 10.49%. In males, the severity of the illness was found to be 32.39% and the occurrence of death was 11.27%. In females, the severity of the illness was found to be 33.96% and the occurrence of death was 12.58%. In patients suffering from chronic obstructive pulmonary disease (COPD), asthma, diabetes mellitus, coronary artery disease (CAD), chronic kidney disease (CKD), cancer, hypertension, chronic liver disease (CLD), cerebrovascular disease, thyroid disease, steroid use, obstructive sleep apnoea (OSA) and smokers, the severity of the illness was 29.27, 41.67, 37.73, 20, 23.53, 11.11, 36.30, 40, 20, 36.37, 50, 54.54 and 36% and the occurrence of death was 14.63, 0, 10.69, 10, 11.76, 5.55, 10.67, 0, 0, 20.78, 0, 0 and 16%, respectively. Conclusion: The age, gender and comorbidity disparities seen in the COVID-19 vulnerability emphasise the need to understand the impact of these factors on the incidence and case fatality of the disease.

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“…This was similar to a study by Collado et al, which showed that the presenting complaints among the patients with CKD were fever, breathlessness, and cough. The inflammatory parameters were also similar among patients with CKD [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Study of Disease Severity and Outcomes in COVID-19 Patients With Chronic Kidney Disease at a Tertiary Care Hospital in South India

Ramamurthy¹,

Rajashekhar²,

Kulkarni³

et al. 2022

Cureus

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Background: Coronavirus disease 2019 (COVID-19) disproportionately affects individuals with various comorbidities. Among these, chronic kidney disease (CKD) has been shown to be strongly associated with the progression to severe disease. This study aimed to assess the severity and disease outcomes in patients with COVID-19 infection and CKD. Methods: This is a retrospective study conducted at a tertiary care hospital from July 2021 to September 2021. The case records of patients with CKD and COVID-19 were studied. They were compared with age and gender-matched controls equally. The presenting symptoms, clinical course, severity of illness, laboratory markers, need for ventilator support, and mortality outcomes were studied. Results: In total, 40 CKD and 40 non-CKD patients with COVID-19 were included in the study. It was also observed that among the patients with CKD, more patients had fever, breathlessness, and diarrhea. The requirement for noninvasive ventilation, ventilator, and inotropes was on the higher average for patients with CKD. Overall mortality was 27.5% in the CKD group and 2.5% in the non-CKD group, which was statistically significant (p = 0.002). Conclusions: COVID-19 patients with CKD had more severe illnesses with a requirement of ventilator support and had higher mortality than the patients without CKD. Patients with CKD are a key subset of patients with COVID-19 for whom more aggressive early treatment and stricter preventive measures may be beneficial.

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COVID-19 in Grade 4–5 Chronic Kidney Disease Patients

Cited by 19 publications

References 12 publications

COVID‐19 death and kidney disease in a multiracial Asian country

COVID‐19 death and kidney disease in a multiracial Asian country

Impact of age, gender and comorbidities affecting the severity of COVID-19 infection in Kashmir

Study of Disease Severity and Outcomes in COVID-19 Patients With Chronic Kidney Disease at a Tertiary Care Hospital in South India

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