COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives

Lauwers, Marianne; Au, Manting; Yuan, Shuofeng; Wen, Chunyi

doi:10.3390/ijms23020720

Cited by 46 publications

(43 citation statements)

References 99 publications

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“…According to some reviews, SARS-CoV-2 could exacerbate the pathological process of degenerative osteoarthritis. ACE2 expression, RAS imbalances, inflammation, and dysfunction at the molecular level have been suggested as the causative factors [ 64 ]. Based on the aforementioned reports, we speculate that systemic inflammation and ischaemia could aggravate cardiac injury in patients with HCM.…”

Section: Discussionmentioning

confidence: 99%

A Bioinformatic Approach Based on Systems Biology to Determine the Effects of SARS-CoV-2 Infection in Patients with Hypertrophic Cardiomyopathy

Han

Wang

Yang

et al. 2022

Computational and Mathematical Methods in Medicine

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Recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has infected millions of individuals worldwide. While COVID-19 generally affects the lungs, it also damages other organs, including those of the cardiovascular system. Hypertrophic cardiomyopathy (HCM) is a common genetic cardiovascular disorder. Studies have shown that HCM patients with COVID-19 have a higher mortality rate; however, the reason for this phenomenon is not yet elucidated. Herein, we conducted transcriptomic analyses to identify shared biomarkers between HCM and COVID-19 to bridge this knowledge gap. Differentially expressed genes (DEGs) were obtained using the Gene Expression Omnibus ribonucleic acid (RNA) sequencing datasets, GSE147507 and GSE89714, to identify shared pathways and potential drug candidates. We discovered 30 DEGs that were common between these two datasets. Using a combination of statistical and biological tools, protein-protein interactions were constructed in response to these findings to support hub genes and modules. We discovered that HCM is linked to COVID-19 progression based on a functional analysis under ontology terms. Based on the DEGs identified from the datasets, a coregulatory network of transcription factors, genes, proteins, and microRNAs was also discovered. Lastly, our research suggests that the potential drugs we identified might be helpful for COVID-19 therapy.

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Section: Discussionmentioning

confidence: 99%

A Bioinformatic Approach Based on Systems Biology to Determine the Effects of SARS-CoV-2 Infection in Patients with Hypertrophic Cardiomyopathy

Han

Wang

Yang

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Although there is evidence of musculoskeletal manifestations involving immune-inflammation-dependent mechanisms and cases of arthralgia and/or myalgia within SARS-CoV-2 ( 34 ), common features and crosstalk between COVID-19 and immune-based RD are still debated. Some similarities have been recently reported between COVID-19 and OA patients like hypocalcemia, vitamin D deficiency, endothelial and adipose tissue dysfunction, neuronal sensitization, and joint and muscle pain ( 35 , 36 ).…”

Section: The Relationship Between Covid-19 and Rheumatic Diseasesmentioning

confidence: 55%

COVID-19 and rheumatic diseases: A mini-review

Roseti

Grigolo

2022

Front. Med.

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Joint pain and arthralgia can be manifestations of COVID-19, and studies evaluating long COVID symptoms identified the persistence of these disorders. Moreover, some case reports highlighted the development of new inflammatory arthritis in patients with COVID-19, suggesting a possible relation. Viral infections and rheumatic diseases share a documented relationship; they have been associated with genetic and environmental risk factors responsible for some of them. There is crosstalk between viruses and the immune system during the development of several rheumatic diseases. Moreover, infections may participate in the pathogenesis of autoimmune rheumatic diseases and contribute to patient mortality. Therefore, it is crucial to provide a clearer insight into the interaction between viral infections and rheumatic diseases. Here, we provide a mini-review of the current literature with the aim of shedding light on the relationship between COVID-19 and rheumatic or musculoskeletal diseases, which is still unclear. Specifically, we examined several aspects: risk for the rheumatic population of acquiring the virus or developing severe symptoms, similarities of COVID-19 and arthritis, the possible rheumatic consequence of COVID-19, of rheumatic drugs and vaccines, and COVID-19 prevention in rheumatic patients through vaccination.

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“…The manifestations are very similar to osteoarthritis, but it is not a viral arthritis as no viral RNA has been found in the joints and the prevalence is much higher. One possible explanation could be hypocalcemia, vitamin D deficiency, and pro-inflammatory cytokine production, alongside the expression of ACE2 and the disruption of RAS [ 62 ], which lead to bone resorption and promote bone loss [ 59 ].…”

Section: Orthopedic Conditions and Covid-19mentioning

confidence: 99%

Connections between Orthopedic Conditions and Oxidative Stress: Current Perspective and the Possible Relevance of Other Factors, Such as Metabolic Implications, Antibiotic Resistance, and COVID-19

et al. 2022

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The general opinion in the literature is that these topics remain clearly understudied and underrated, with many unknown aspects and with controversial results in the respective areas of research. Based on the previous experience of our groups regarding such matters investigated separately, here we attempt a short overview upon their links. Thus, we summarize here the current state of knowledge regarding the connections between oxidative stress and: (a) orthopedic conditions; (b) COVID-19. We also present the reciprocal interferences among them. Oxidative stress is, of course, an interesting and continuously growing area, but what exactly is the impact of COVID-19 in orthopedic patients? In the current paper we also approached some theories on how oxidative stress, metabolism involvement, and even antibiotic resistance might be influenced by either orthopedic conditions or COVID-19. These manifestations could be relevant and of great interest in the context of this current global health threat; therefore, we summarize the current knowledge and/or the lack of sufficient evidence to support the interactions between these conditions.

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COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives

Cited by 46 publications

References 99 publications

A Bioinformatic Approach Based on Systems Biology to Determine the Effects of SARS-CoV-2 Infection in Patients with Hypertrophic Cardiomyopathy

A Bioinformatic Approach Based on Systems Biology to Determine the Effects of SARS-CoV-2 Infection in Patients with Hypertrophic Cardiomyopathy

COVID-19 and rheumatic diseases: A mini-review

Connections between Orthopedic Conditions and Oxidative Stress: Current Perspective and the Possible Relevance of Other Factors, Such as Metabolic Implications, Antibiotic Resistance, and COVID-19

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