COVID-19 in pregnancy, management and outcomes among pregnant women and neonates — results from tertiary care center in Wroclaw

Abstract

Objectives: A novel coronavirus -SARS-CoV-2 -outbreak has, for sure, been the greatest medical challenge in recent years. The maternal and neonatal consequences of the infection are still largely unknown. Material and methods:This prospective study aims to describe the perinatal care and outcomes of SARS-CoV-2 positive pregnant women and their newborn infants during the third wave of the pandemic, in a large tertiary university center in Wroclaw/Poland from 15 February to 1 May 2021. Results:The paper describes a group of 83 women with confirmed SARS-CoV-2 infection during delivery, as well as their newborn infants (n = 84). The course of COVID-19 disease in pregnant patients was mostly asymptomatic (54.2%) but 31% women manifested mild to moderate symptoms and 14% had severe infection. The median gestational age at the delivery was 39 weeks. On average, 16.7% of mothers were separated from their newborns at birth, 83.3% practiced skin-to-skin, and roomed in with their babies, and 84.5% of the infants received any mother's milk. Preterm infants were more often born by mothers with symptomatic course of COVID-19 infection. Need for neonatal treatment was only due to prematurity. Neonates with acquired infection (after 14 th day of life) had to be treated symptomatically with fever and loose stools, only 28.5% had symptoms of respiratory failure.Conclusions: Despite the confirmed SARS-CoV-2 infection, the majority of mother-infant dyads were in a good health condition. The data on perinatal care reported in the paper could be helpful contribution supporting childbirth physiology protection during the COVID-19 pandemic.

Mother-to-child transmission of SARS-CoV-2 infection in high-income countries: a systematic review and meta-analysis of prospective observational studies

“…Among 1536 articles retained after duplication removal, we finally included 26 prospective studies 13 – 38 . Most studies (N = 21) were conducted during 2020, one in 2021 and four between 2020 and 2021 (Table 1 ).…”

Angiotensin converting enzyme 2 (ACE2): Virus accomplice or host defender

“…6g). And the comparison of asymptomatic infection in pregnancy is quite high [62][63][64][65][66] (Fig. 6h), which proves the important role of ACE2 in asymptomatic infection.…”

Severe course of COVID-19 in pregnant woman and newborn’s alloimmune thrombocytopenia — case study and review of the literature

“…Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared a pandemic by WHO on March 11, 2020. Pregnant women are particularly affected, but little is known about the impact of the coronavirus disease 2019 (COVID-19) on pregnancy and vice versa. The rate of preterm birth incidence in SARS-CoV-2 positive patients is 20% reported by Chen et al [1] (out of 118 pregnancies), 17% by Allotey et al [2] and 18,1% by Szczygiol et al [3] Although current evidence suggest that development of severe COVID-19 in neonates is rare, in some cases there is necessity of NICU admission estimated in studies to 21.4 % [3], 23% [4], 25% [2].…”