COVID-19 in Russia: Evolution of Views on the Pandemic. Report I

Стародубов, В. И.; Береговых, В. В.; Акимкин, В. Г.; Semenenko, Т. A.; Углева, С. В.; Avdeev, S. N.; Zykov, K. A.; Трофимова, Т. Н.; Переходов, С. Н.; Кузин, С. Н.; Yatsyshina, S. B.; Petrov, Vadim V.; Khafizov, K.; Дубоделов, Д. В.; Gasanov, Gasan A.; Svanadze, Nino Kh.; Cherkashina, Anna S.; Sinitsyn, E. A.; Rvacheva, A. V.; Sergeeva, Natal’ya V.; Polosova, Tat’yana A.; Зыкова, А А; Zelenin, D A; Gorbenko, Mihail Yu.; Rodyukova, Irina S.; Chaus, N. I.; Snitsar, A V

doi:10.15690/vramn2118

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…B.1.617.2, the Delta variant detected in October 2020, was identified by WHO as VOC on 11 May 2021. In Russia, Delta began to actively spread in the second half of April 2021 and prevailed until January 2022 [ 10 ]. The increased transmissibility of the Delta variant is associated with critical mutations such as L452R, P681R, and T478K in the S-protein.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 Variants Monitoring Using Real-Time PCR

et al. 2022

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According to the temporary recommendations of the 2021 World Health Organization (WHO), in addition to whole-genome sequencing, laboratories in various countries can also screen for known mutations utilizing targeted RT-PCR-based mutation detection assays. The aim of this work was to generate a laboratory technique to differentiate the main circulating SARS-CoV-2 variants in 2021–2022, when a sharp increase in morbidity was observed with the appearance of the Omicron variant. Real-time PCR methodology is available for use in the majority of scientific and diagnostic institutions in Russia, which makes it possible to increase the coverage of monitoring of variants in the territories of all 85 regions in order to accumulate information for the Central Services and make epidemiological decisions. With the methodology developed by the Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (FSSCRP Human Wellbeing) (CRIE), more than 6000 biological samples have been typed, and 7% of samples with the Delta variant and 92% of samples with the Omicron variant have been identified as of 25 August 2022. Reagents for 140,000 definitions have been supplied to regional organizations.

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Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 Variants Monitoring Using Real-Time PCR

et al. 2022

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“…It was on the basis of epidemiological analysis and clear criteria for assessing the epidemic situation that decisions were made to restrict air travel, the work of production enterprises, business organizations, educational and cultural institutions, etc. [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Epidemic Process and Evolution of SARS-CoV-2 Genetic Variants in the Russian Federation

Akimkin,

Semenenko,

Ugleva

et al. 2024

Microbiology Research

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The COVID-19 pandemic, etiologically related to a new coronavirus, has had a catastrophic impact on the demographic situation on a global scale. The aim of this study was to analyze the manifestations of the COVID-19 epidemic process, the dynamics of circulation, and the rate of the spread of new variants of the SARS-CoV-2 virus in the Russian Federation. Retrospective epidemiological analysis of COVID-19 incidence from March 2020 to fall 2023 and molecular genetic monitoring of virus variability using next-generation sequencing technologies and bioinformatics methods were performed. Two phases of the pandemic, differing in the effectiveness of anti-epidemic measures and the evolution of the biological properties of the pathogen, were identified. Regularities of SARS-CoV-2 spread were determined, and risk territories (megacities), risk groups, and factors influencing the development of the epidemic process were identified. It was found that with each subsequent cycle of disease incidence rise, the pathogenicity of SARS-CoV-2 decreased against the background of the increasing infectiousness of SARS-CoV-2. Data on the mutational variability of the new coronavirus were obtained using the Russian platform of viral genomic information aggregation (VGARus) deployed at the Central Research Institute of Epidemiology. Monitoring the circulation of SARS-CoV-2 variants in Russia revealed the dominance of Delta and Omicron variants at different stages of the pandemic. Data from molecular genetic studies are an essential component of epidemiologic surveillance for making management decisions to prevent the further spread of SARS-CoV-2 and allow for prompt adaptation to pandemic control tactics.

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Thyroid status and TNF-alpha in post-reproductive women with COVID-19 and 12 months after the disease

Semenova,

Kolesnikov,

Vyrupaeva

et al. 2023

Acta biomedica scientifica

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The aim. To assess the thyroid status and its relationship with tumor necrosis factor alpha (TNF-alpha) in post-reproductive women in the acute phase of the COVID-19 of moderate course and 12 months after the disease.Materials and methods. 85 women aged 45 to 69 years were divided into groups: women without COVID-19, not vaccinated, with no antibodies to COVID-19 (IgG) – control group (n = 15); women in the acute phase of COVID-19 of a moderate course, accompanied by pneumonia – main group (n = 57); patients from the main group who agreed to be examined 12 months after having COVID-19 (n = 14); women with IgG in blood who deny any symptoms of COVID-19 in the last 12 months – asymptomatic COVID-19 (n = 13). Using hormone replacement therapy and the presence of thyroid disease in history were the exclusion criteria from the study.Results. 75.4 % of patients with COVID-19 had euthyroidism, 12.3 % had subclinical hyperthyroidism. An increase of free thyroxine (free T4) level in women with COVID-19 as compared to the control group (p = 0.004) and the group with asymptomatic COVID-19 (p = 0.054) was found. There was no statistically significant difference in the level of thyroid stimulating hormone between the groups. The level of C-reactive protein in women with COVID-19 was naturally higher as compared to the control group (p = 0.009) and the group of asymptomatic patients (p = 0.001). A lower TNF-alpha level was found in the group of patients without clinical signs of COVID-19 as compared to the control group (p = 0.007) and the group with COVID-19 (p = 0.00007). The analysis of correlation relationships revealed a positive correlation between of free T4 and TNF-alpha levels in women with COVID-19 (r = 0.38, p = 0.004).Conclusions. The moderate course of COVID-19 in the post-reproductive women is associated with an increase of free T4 level, which positively correlates with TNF-alpha level. Twelve months after COVID-19, thyroid status in women remains at the level of the acute phase of the disease.

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COVID-19 in Russia: Evolution of Views on the Pandemic. Report I

Cited by 7 publications

References 21 publications

SARS-CoV-2 Variants Monitoring Using Real-Time PCR

SARS-CoV-2 Variants Monitoring Using Real-Time PCR

COVID-19 Epidemic Process and Evolution of SARS-CoV-2 Genetic Variants in the Russian Federation

Thyroid status and TNF-alpha in post-reproductive women with COVID-19 and 12 months after the disease

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