The emergence of the global COVID-19 pandemic has continued to cause havoc and untold suffering worldwide. The pandemic’s pattern of spreading has varied between continents and indeed within countries. Studies looking at the factors affecting the dynamics of COVID-19 in African countries are limited. In this study we attempt to assess and understand the differential spread of COVID-19 in Africa by looking at South Africa (Southern Africa), Senegal (West Africa), Egypt and Morocco (North Africa), Rwanda (Central Africa) and Kenya (East Africa). We observed a high prevalence of COVID-19 in South Africa, Morocco and Egypt. Furthermore, South Africa ranks first in the number of reported confirmed COVID-19 cases and related hospitalisations and deaths in Africa. Senegal (Western Africa) shows lower confirmed cases and death rates. Based on the findings, it is crucial for these countries’ governments and health authorities to be vigilant in mobilising effective medical resources and to continue educating their citizens in order to curb the spread of the coronavirus.