COVID-19 in the elderly people and advances in vaccination approaches

Dhama, Kuldeep; Patel, Shailesh Kumar; Natesan, Senthilkumar; Vora, Kranti; Yatoo, Mohd Iqbal; Tiwari, Ruchi; Saxena, Shailendra K.; Singh, Karam Pal; Singh, Rajendra; Malik, Yashpal Singh

doi:10.1080/21645515.2020.1842683

Cited by 49 publications

(39 citation statements)

References 76 publications

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“…22,[35][36][37][38] This presumably because the immune function decreases with age and the incidence and mortality of COVID-19 are relatively higher in older adults. 39 Furthermore, young people often do not have a strong demand for vaccines and tend to adopt a wait-and-see attitude. This attitude was likely heightened because the pandemic was effectively controlled in China.…”

Section: Discussionmentioning

confidence: 99%

The landscape of COVID-19 vaccination among healthcare workers at the first round of COVID-19 vaccination in China: willingness, acceptance and self-reported adverse effects

Wan²,

Yu³

et al. 2021

Preprint

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Background: Vaccination is a crucial measure in preventing the spread of epidemic. Vaccines targeting coronavirus disease 2019 (COVID-19) have been developed in a wide range of countries. Objective: This study aims to examine factors influencing vaccination rate and willingness to vaccinate against COVID-19 among Chinese healthcare workers (HCWs). Methods: From 3rd February to 18th February, 2021, an online cross-sectional survey was conducted among HCWs to investigate factors associated with the acceptance and willingness of COVID-19 vaccination. Respondents were classified into two categories, vaccinated and unvaccinated, and, the willingness of vaccination was assessed in the unvaccinated group. Information on socio-demographics and the psychological process of the participants for accepting the vaccine were evaluated. Results: A total of 2156 HCWs from 21 provinces in China responded to this survey (response rate: 98.99%)), among whom 1433 (66.5%) were vaccinated at least one dose. Higher vaccination rates were associated with older age (40-50 years vs. less than 30 years, OR=1.63, 95%CI: 1.02-2.58; >50 years vs. 30 years, OR=1.90, 95%CI: 1.02-3.52), working as a clinician (OR=1.54, 95% CI: 1.05-2.27), having no personal religion (OR=1.35, 95%CI: 1.06-1.71), working in a fever clinic (OR=4.50 , 95%CI:1.54-13.17) or higher hospital level(Municipal vs. County, OR=2.01, 95%CI: 1.28-3.16; Provincial vs. County, OR=2.01, 95%CI: 1.25-3.22) and having knowledge training of vaccine (OR=1.67, 95%CI:1.27-2.22), family history for influenza vaccination (OR=1.887, 95%CI:1.49-2.35) and strong familiarity with the vaccine (OR=1.43, 95%CI:1.05-1.95) (All P<0.05). Strong willingness for vaccination was related to having a working in midwestern China (OR=1.89, 95%CI:1.24-2.89), considerable knowledge of the vaccine (familiar vs. not familiar, OR=1.67, 95%CI: 1.17-2.39; strongly familiar vs. not familiar, OR=2.47, 95%CI: 1.36-4.49), knowledge training of vaccine(OR=1.61, 95%CI: 1.05-2.48) and strong confidence in the vaccine (OR=3.84 , 95%CI: 2.09-7.07). Conclusion: Personal characteristics, working environments, familiarity and confidence in the vaccine were related to vaccination rates and willingness to get vaccinated among healthcare workers. Results of this study could provide evidence for the government to improve vaccine coverage by addressing vaccine hesitancy in the COVID-19 pandemic and future public health emergencies.

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Section: Discussionmentioning

confidence: 99%

The landscape of COVID-19 vaccination among healthcare workers at the first round of COVID-19 vaccination in China: willingness, acceptance and self-reported adverse effects

Wan²,

Yu³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Geriatric populations are at high risk of COVID-19-associated mortality [37]. Their reduced immunity and age-related organ functional decline predispose them to a higher infection risk, leading to fatal outcomes [38,39].…”

Section: Geriatric Populationmentioning

confidence: 99%

COVID-19 Vaccinations: A Comprehensive Review of Their Safety and Efficacy in Special Populations

2021

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COVID-19 has been spreading worldwide since late 2019. There is no definitive cure to date. Global vaccination programs are urgently required to confer herd immunity, reducing the incidence of COVID-19 infections and associated morbidity and mortality. However, a significant proportion of special populations are hesitant to receive vaccination due to their special conditions, namely, age (pediatrics and geriatrics), immunocompromised state, autoimmune diseases, chronic cardiovascular and pulmonary conditions, active or treated cancers, and pregnancy. This review aims to evaluate the existing evidence of COVID-19 vaccinations on these special populations and to provide clues to guide vaccination decision making to balance the benefits and risks of vaccinations.

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“…The key objective of COVID-19 vaccines is to contribute significantly to the equitable protection and promotion of human well-being, based on reciprocity and legitimacy for all people around the world, at the global and national level ( 130 , 133 , 134 ). Besides, focus should be put on older adults, pregnant and lactating mothers in clarifying gender-based biological disparities in the efforts of vaccine production clinical trials to ensure safety and efficacy ( 135 , 136 ).…”

Section: Integrated Strategic Approaches Against the Covid-19 Pandemic And Lesson Learned In Combating The Crises Mirroring Ways To Safegmentioning

confidence: 99%

Expected Impacts of COVID-19: Considering Resource-Limited Countries and Vulnerable Population

Gashaw

Hagos

Sisay

2021

Front. Public Health

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Coronavirus disease in 2019 emerged in Wuhan, Hubei Province, China, in December 2019. After a month, it was declared a global threat to public health. The effects of the pandemic could be socio-economic, undermining the health system and risking livelihoods. Vulnerability to this infection has been associated with underlying comorbidities such as hypertension, diabetes, coronary heart disease, chronic respiratory diseases, cancer, and compromised immune systems. Co-morbidity has been common to the elderly, the disabled, and the homeless. In addition, more severe coronavirus disease outcomes have been reported in older males than females. Nonetheless, multiple variables are related to the concept of cultural gender that should be taken into account as women in more affected sectors are economically disadvantageous and over-represented. Similarly, although children are not the face of this pandemic, calamity has a profound effect on their welfare, especially for those living in poor and inconvenient situations. Moreover, the economic influence could be profound and universal when viewed through a migration lens as it is exacerbating xenophobic and discriminatory treatment. Protection measures to mitigate the outbreak of a pandemic, such as social distancing, may reduce social support for certain categories relied on for their day-to-day activities. The mental health of people would definitely be affected by the additional psychosocial burden of the pandemic, particularly in vulnerable groups. Integrated approaches are therefore mandatory to assist these groups and contain the pandemic.

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COVID-19 in the elderly people and advances in vaccination approaches

Cited by 49 publications

References 76 publications

The landscape of COVID-19 vaccination among healthcare workers at the first round of COVID-19 vaccination in China: willingness, acceptance and self-reported adverse effects

The landscape of COVID-19 vaccination among healthcare workers at the first round of COVID-19 vaccination in China: willingness, acceptance and self-reported adverse effects

COVID-19 Vaccinations: A Comprehensive Review of Their Safety and Efficacy in Special Populations

Expected Impacts of COVID-19: Considering Resource-Limited Countries and Vulnerable Population

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