COVID-19 induced follicular lymphoma remission

Baptista, Renata Lyrio; Moreira, Renata; Rego, Eduardo Magalhães

doi:10.1016/j.htct.2022.01.017

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…There are few case reports about lymphoma remissions after bacterial or virus infections, including recently the SARs-CoV-2 infection, suggesting that the infection can trigger the immune system against the tumor cell. Although there is none associated with vaccination, there are no cases reported yet ( 12 , 13 ).…”

Section: Discussionmentioning

confidence: 99%

Spontaneous remission of a pulmonary sclerosing epithelioid fibrosarcoma: a case report of a possible abscopal effect

Campos Ramírez,

Gómez Mateo,

Ruffini Egea

et al. 2024

Transl Cancer Res

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Background Spontaneous remission (SR) is defined as the complete or partial disappearance of a diagnosed malignant disease in the absence of known active medical treatment. The role of the immune system is thought to be important, but has not yet been elucidated. On this matter, there are studies that suggest that the abscopal effect (AE), which is defined as the remission of untreated lesions beyond the irradiated area, may be explained by the activation of a systemic immune response against the tumor. Sclerosing epithelioid fibrosarcoma (SEF) is a rare variant of soft tissue sarcoma that is characterized by a slow evolution, with local recurrences and late metastases. The treatment is based on surgery, leaving a minimal role to chemotherapy (ChT) and radiotherapy (RT) for metastatic unresectable disease, and no cases of SR have been reported in the literature so far. Case Description We present the case of a patient with a lung metastatic recurrence of SEF, diagnosed and treated with surgery 8 years before. After progression to pazopanib and other ChT drugs, because of the chest pain associated with a pleural mass invading the second costal arch, the patient received antalgic local RT treatment. Months later, and without any further treatment, a partial remission of all the tumoral lesions was presented, and she is alive 25 years after the first diagnosis. Conclusions As far as reported in the literature, this is the first case of SR in SEF. Among the possible causes of this SR, we think that the most plausible is that palliative treatment with RT of the pleural mass induced an AE, leading to a reduction of all tumoral lesions, even those outside the irradiated region.

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Section: Discussionmentioning

confidence: 99%

Spontaneous remission of a pulmonary sclerosing epithelioid fibrosarcoma: a case report of a possible abscopal effect

Campos Ramírez,

Gómez Mateo,

Ruffini Egea

et al. 2024

Transl Cancer Res

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“…Reported cases included patients diagnosed with lymphoma, multiple myeloma, chronic lymphocytic leukemia, renal cell carcinoma, and colorectal carcinoma, with most of the cases related to hematologic neoplasms, suggesting higher spontaneous remission rates for these malignancies. 2,[5][6][7][8][9][10] Extended patient follow-up and research are required to fully understand the molecular mechanisms, confirm the relationship between COVID-19 disease and cancer, and determine the clinical implications of these interactions. 5…”

mentioning

confidence: 99%

“…Over the last 3 years, a limited number of cases describing the antitumor effect of SARS-CoV-2 have been reported in the literature, with only a small part of these involving patients who did not receive any antineoplastic treatment. Reported cases included patients diagnosed with lymphoma, multiple myeloma, chronic lymphocytic leukemia, renal cell carcinoma, and colorectal carcinoma, with most of the cases related to hematologic neoplasms, suggesting higher spontaneous remission rates for these malignancies 2,5–10 . Extended patient follow-up and research are required to fully understand the molecular mechanisms, confirm the relationship between COVID-19 disease and cancer, and determine the clinical implications of these interactions 5 …”

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confidence: 99%

Spontaneous Remission of High-Grade Non-Hodgkin Lymphoma After SARS-CoV-2 Infection

Teixeira Ferreira,

Cardoso Ferreira,

Carmona

et al. 2023

Clin Nucl Med

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Despite extensive research into COVID-19 since its emergence in late 2019, there is still much not fully understood about its long-term effects. When infected with SARS-CoV-2, cancer patients have been reported to be at higher risk for unfavorable outcomes. Nevertheless, evidence suggests that viruses may exhibit an antitumor effect in some cases, which has recently been anecdotally reported with SARS-CoV-2. We present the case of a patient with a recent high-grade non-Hodgkin lymphoma diagnosis and without any cancer-specific therapy, in whom a complete metabolic response on 2-[18F]FDG PET/CT was observed after COVID-19.

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Tumor lysis syndrome followed by tumor regression after COVID-19 in a patient with chronic lymphocytic leukemia

Yasumi,

Yamamoto,

Kamijo

et al. 2023

Int Canc Conf J

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COVID-19 induced follicular lymphoma remission

Cited by 4 publications

References 5 publications

Spontaneous remission of a pulmonary sclerosing epithelioid fibrosarcoma: a case report of a possible abscopal effect

Spontaneous remission of a pulmonary sclerosing epithelioid fibrosarcoma: a case report of a possible abscopal effect

Spontaneous Remission of High-Grade Non-Hodgkin Lymphoma After SARS-CoV-2 Infection

Tumor lysis syndrome followed by tumor regression after COVID-19 in a patient with chronic lymphocytic leukemia

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