COVID-19 infection among pregnant and non-pregnant women: Comparison of biochemical markers and outcomes during COVID-19 pandemic, A retrospective cohort study

Asghar, Muhammad Sohaib; Siddiqui, Muhammad Ali; Iqbal, Sadia; Tahir, Muhammad Junaid; Yasmin, Farah; Chughtai, Najeebullah; Khan, Farmanullah; Kirmani, Tooba Ahmed; Lareeb, Iqra

doi:10.1016/j.amsu.2022.103527

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…Our study showed fewer mortalities in pregnant subjects than in nonpregnant counterparts. This finding is supported by multiple studies that showed lower in-hospital death in pregnant than in nonpregnant patients [ 21 , 24 , 25 , 26 ]. However, factors other than pregnancy could have influenced this low mortality rate.…”

Section: Discussionsupporting

confidence: 74%

Clinical Outcomes of COVID-19 Infection in Pregnant and Nonpregnant Women: Results from The Philippine CORONA Study

et al. 2023

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Objective: Our study determined the association of pregnancy with various clinical outcomes among women with COVID-19 infection. Methods: We conducted a retrospective, cohort, subgroup analysis of the Philippine CORONA Study datasets comparing the clinical/neurological manifestations and outcomes of pregnant and nonpregnant women admitted in 37 Philippine hospitals for COVID-19 infection. Results: We included 2448 women in the analyses (322 pregnant and 2.126 nonpregnant). Logistic regression models showed that crude odds ratio (OR) for mortality (OR 0.26 [95% CI 0.11, 0.66]), respiratory failure [OR 0.37 [95% CI 0.17, 0.80]), need for intensive care (OR 0.39 [95% CI 0.19, 0.80]), and prolonged length of hospital stay (OR 1.73 [95% CI 1.36, 2.19]) among pregnant women were significant. After adjusting for age, disease severity, and new-onset neurological symptoms, only the length of hospital stay remained significant (adjusted OR 1.99 [95% CI 1.56,2.54]). Cox regression models revealed that the unadjusted hazard ratio (HR) for mortality (HR 0.22 [95% CI 0.09, 0.55]) among pregnant women was statistically significant; however, after adjustment, the HR for mortality became nonsignificant. Conclusion: We did not find a significantly increased risk of mortality, respiratory failure, and need for ICU admission in pregnant women compared with nonpregnant women with COVID-19. However, the likelihood of hospital confinement beyond 14 days was twice more likely among pregnant women than nonpregnant women with COVID-19.

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Section: Discussionsupporting

confidence: 74%

Clinical Outcomes of COVID-19 Infection in Pregnant and Nonpregnant Women: Results from The Philippine CORONA Study

et al. 2023

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“…al. shows a similar D-Dimer concentration among asymptomatic, mild, moderate and severe COVID-19 in pregnant women 28 , and our study agrees with this observation. Another potential biomarker is the PCT, however, the value of this biomarker to predict severity in COVID-19 show some contradictory results in general population 19 , and in pregnant women with COVI-19, PCT levels was similar between pregnant and non-pregnant women with COVID-19 41,50 , while some other study show a difference between them 27 . Because the PCT was similar among mild, moderate and severe COVID-19 in pregnant women 28 , the result suggest that PCT is not able to discriminate the mild from severe COVID-19 in pregnant women, our study agrees with this observation, we observed that the highest PCT concentration was in the mild cases, in the mild group we observed patients with PCT values quite similar to severe COVID-19 patients (range 0.010-11.0 ng/mL) and a subgroup of mild COVID-19 patients with high values of PCT (918.0-5227.0 ng/mL), suggesting that this second subgroup got a bacterial infection, however, we could not get a positive bacterial culture on them, interestingly, none of this potential over infected patients got a fatal outcome, suggesting that even in the case of double infection the immune system of pregnant women will be sufficient to solve the infection challenge.…”

Section: Resultsmentioning

confidence: 97%

The Colloido-Osmotic Pressure as a useful biomarker of fatal outcome in pregnant COVID-19 patients

Zavala-Barrios,

Cérbulo-Vázquez,

García-Espinosa

et al. 2023

Preprint

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Background: Pregnancy was considering a health condition that could support high severity in COVID-19, among others the cardiologic and respiratory systems express some physiologic change in the pregnant women and could specially affected in COVID-19. Pregnant women characteristically have an increase volume of blood, with a higher cardiac output and lower peripheral vascular resistance, these could be negative affected by hypoalbuminemia frequently observed in COVID-19. Then, an early recognition of hypoalbuminemia in pregnant women with COVID-19 would help us to predict fatal outcome. Objective: We conduct a study to analyzed the demographic, clinical, blood gas test results, laboratory and ultrasonographic doppler data in pregnant women with COVID-19 that demand medical attention for labor. Study design: Ninety-two pregnant women with COVID-19 were included in our study from may 30th 2020 to august 12th 2022, and data was analyzed in survival and fatal outcome patients. Normality test were applied to data and parametric or non-parametric test were used to determine statistical difference between or among data. Results: Demographic and clinical data were quite similar between survival and fatal outcome pregnant patients with COVID-19. Also, blood gas test shown similar results among groups (asymptomatic, mild, or severe patients who survive COVID-19 or fatal outcome patients). We observed that serum albumin was consistently low in pregnant patients with fatal outcome by COVID-19, then based on Total Protein concentration in serum we calculated the colloido-osmotic pressure and we evaluate its utility as predictor of fatal outcome. ROC analysis and Kaplan-Meier of survival curves suggest that the colloido-osmotic pressure could be a potential predictor. Also, we observed an association of low colloido-osmotic pressure and low amniotic fluid index. Conclusion: Our study suggests that early evaluation of pregnant with COVID-19 must include the calculation of colloido-osmotic pressure and the doppler analysis to early recognition of fatal outcome in pregnant women with COVID-19.

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Section: Introductionmentioning

confidence: 99%

“…21,22 While some studies suggest that COVID-19 may pose a heightened risk to pregnant women, 14,15 others argue that the severity of the disease may not significantly differ in non-pregnant populations. 23,24 This divergence underscores the necessity for further research, particularly in regions where data is lacking. In light of the limited research on COVID-19's impact on pregnant women in Saudi Arabia, this study aims to evaluate the severity of COVID-19 among pregnant women admitted to hospitals in the Jazan region of Saudi Arabia and assess maternal outcomes and risk factors associated with the disease.…”

Section: Introductionmentioning

confidence: 99%

Characteristics and Outcomes of Coronavirus Disease- 2019 Among Pregnant Women in Saudi Arabia; a Retrospective Study

Abdelmola,

Albasheer,

Kariri

et al. 2024

IJWH

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Background Pregnancy-related coronavirus disease 2019 infection ranges from asymptomatic to very serious illness. This study aimed to determine the impact of the COVID-19 infection on pregnant women in the Jazan region of Saudi Arabia. Methods Retrospective observational study of women who had COVID-19 positive test in pregnancy admitted in King Fahd Hospital, Abu Arish General Hospital, and Sabya General Hospital, Jazan, Saudi Arabia during the period between March 2020 and March 2022. Data were extracted from the patient’s records. Frequency and percentage distributions were calculated for categorical variables. Descriptive studies and regression analysis were conducted to evaluate the association between selected variables and pregnancy outcomes. Results Of the 33 pregnant women with confirmed infection, the majority were in their second and third trimester, with approximately 42.4% requiring intensive care unit (ICU) admission and oxygen therapy. The most prevalent symptoms were high respiratory rate and low blood pressure, often accompanied by fever, cough, and shortness of breath. Live births resulted in 54.5% of the cases, while two maternal deaths were reported. Significant associations were found between the need for non-invasive ventilation and timing of infection (p = 0.026), the mode of delivery and timing of infection (p = 0.036), and the mode of delivery and body mass index (BMI) (p = 0.007). Conclusion COVID-19 poses significant risks to pregnant women, particularly in the third trimester, and emphasized the importance of early identification of high-risk pregnancies, strategic planning, and enhanced monitoring during antenatal care.

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COVID-19 infection among pregnant and non-pregnant women: Comparison of biochemical markers and outcomes during COVID-19 pandemic, A retrospective cohort study

Cited by 5 publications

References 21 publications

Clinical Outcomes of COVID-19 Infection in Pregnant and Nonpregnant Women: Results from The Philippine CORONA Study

Clinical Outcomes of COVID-19 Infection in Pregnant and Nonpregnant Women: Results from The Philippine CORONA Study

The Colloido-Osmotic Pressure as a useful biomarker of fatal outcome in pregnant COVID-19 patients

Characteristics and Outcomes of Coronavirus Disease- 2019 Among Pregnant Women in Saudi Arabia; a Retrospective Study

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