COVID-19 infection and children: A comprehensive review

Mehrabani, Sanaz

doi:10.4103/ijpvm.ijpvm_277_20

Cited by 3 publications

(3 citation statements)

References 57 publications

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“…Moreover, people with underlying health conditions, which include diabetes, cardiovascular diseases, or most cancers, are at a higher risk of death than those without these health conditions. Recent studies have additionally suggested cases of COVID-19 infections in kids (Mehrabani, 2020 ). Notably, the general population tested for an additional occurrence of SARS-CoV-2 (0.15%) in comparison to CF patients (0.07%; Cosgriff et al, 2020 ).…”

Section: Epidemiological and Clinical Outcomes Of Sars-cov-2 In Cf Pa...mentioning

confidence: 99%

Occurrence of COVID-19 in cystic fibrosis patients: a review

Abolhasani,

Moein,

Rezaie

et al. 2024

Front. Microbiol.

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Cystic fibrosis (CF) is a genetic ailment caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. This autosomal recessive disorder is characterized by diverse pathobiological abnormalities, such as the disorder of CFTR channels in mucosal surfaces, caused by inadequate clearance of mucus and sputum, in addition to the malfunctioning of mucous organs. However, the primary motive of mortality in CF patients is pulmonary failure, which is attributed to the colonization of opportunistic microorganisms, formation of resistant biofilms, and a subsequent decline in lung characteristics. In December 2019, the World Health Organization (WHO) declared the outbreak of the radical coronavirus disease 2019 (COVID-19) as a worldwide public health crisis, which unexpectedly spread not only within China but also globally. Given that the respiration system is the primary target of the COVID-19 virus, it is crucial to investigate the impact of COVID-19 on the pathogenesis and mortality of CF patients, mainly in the context of acute respiratory distress syndrome (ARDS). Therefore, the goal of this review is to comprehensively review the present literature on the relationship between cystic fibrosis, COVID-19 contamination, and development of ARDS. Several investigations performed during the early stages of the virus outbreak have discovered unexpected findings regarding the occurrence and effectiveness of COVID-19 in individuals with CF. Contrary to initial expectancies, the rate of infection and the effectiveness of the virus in CF patients are lower than those in the overall population. This finding may be attributed to different factors, including the presence of thick mucus, social avoidance, using remedies that include azithromycin, the fairly younger age of CF patients, decreased presence of ACE-2 receptors, and the effect of CFTR channel disorder on the replication cycle and infectivity of the virus. However, it is important to notice that certain situations, which include undergoing a transplant, can also doubtlessly boost the susceptibility of CF patients to COVID-19. Furthermore, with an increase in age in CF patients, it is vital to take into account the prevalence of the SARS-CoV-2 virus in this population. Therefore, ordinary surveillance of CF patients is vital to evaluate and save the population from the capability of transmission of the virus given the various factors that contribute to the spread of the SARS-CoV-2 outbreak in this precise organization.

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Section: Epidemiological and Clinical Outcomes Of Sars-cov-2 In Cf Pa...mentioning

confidence: 99%

Occurrence of COVID-19 in cystic fibrosis patients: a review

Abolhasani,

Moein,

Rezaie

et al. 2024

Front. Microbiol.

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“…Symptoms in children will be milder, including cough, fever, sore throat, myalgia sneezing, and fatigue, but adults will be more severely affected. Lymphopenia may or may not be present and it seems to be less pronounced than in adults [ 85 , 86 ].…”

Section: Diagnosis and Testingmentioning

confidence: 99%

The COVID-19 pandemic in children and young people during 2020-2021: Learning about clinical presentation, patterns of spread, viral load, diagnosis and treatment

et al. 2021

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“…Results showed that the majority of COVID-19 deaths occurred with reduced oxygen saturation levels and elevated lactate dehydrogenase and erythrocyte sedimentation levels on admission in male elderly people [22]. Elevated amounts of C-reactive protein (CRP) reported in laboratory test results, which suggesting the infection by COVID-19 [23]. [24] stated that poor prognosis is associated with multiple laboratory features, including LDH and CPK.…”

Section: Biochemical Parameter Values Between Healthy Control Individ...mentioning

confidence: 99%

COMPARATIVE STUDY of SOME BIOCHEMICAL PARAMETERS AMONG of COVID-19 SYMPTOMS and NON COVID-19 SYMPTOMS IN-DIVIDUALS

Rostam

Shekhany

Smail

2020

BIOV

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Nowadays in the Kurdistan region of Iraq, the number of patients have common symptoms with COVID-19 infection rapidly increased. 123 patients which they had common symptoms with COVID-19 and 94 healthy control individuals (non-COVID-19) were subjected for quantitative analysis for each one of the following biochemical parameters, Lactate dehydrogenase (LDH), Creatine Phosphokinase (CPK), and C-reactive protein (CRP) in Erbil, Kurdistan Region of Iraq. We analyze clinical features and compared the differences between COVID-19 and non-COVID-19 symptoms. Among the healthy control individuals, the absolute value of LDH, CPK Creatine Kinase and CRP were determined in between the normal range, and in compare with patients with COVID-19 symptoms their values were smaller and, the P value was (P ＜0.05). All three biochemical parameters increased among patients with COVID-19 symptoms, but more significantly, steadily increase was observed only in LDH value in age above and under 40 years (284.43±10.29 and 321.23±16.32 U/L), and p-value was (0.0488). Male patients had higher levels of LDH (299.32±11.42 U/L), CPK Creatine Kinase (195.90±26.65 mg/L), and C-Reactive Protein (5.86±3.96 mg/L) in compared with the female patients. Our study suggested that among patients who have COVID 19 symptoms, increased LDH is the advised and helpful biochemical marker among routine panel for COVID-19 infection evaluation. Also, CRP levels were positively correlated with male patients when compared with the healthy control.

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COVID-19 infection and children: A comprehensive review

Cited by 3 publications

References 57 publications

Occurrence of COVID-19 in cystic fibrosis patients: a review

Occurrence of COVID-19 in cystic fibrosis patients: a review

The COVID-19 pandemic in children and young people during 2020-2021: Learning about clinical presentation, patterns of spread, viral load, diagnosis and treatment

COMPARATIVE STUDY of SOME BIOCHEMICAL PARAMETERS AMONG of COVID-19 SYMPTOMS and NON COVID-19 SYMPTOMS IN-DIVIDUALS

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