COVID-19 infection and severe rhabdomyolysis

Patel, Vishal; Alzghoul, Bashar; Kalra, Saminder

doi:10.1080/08998280.2021.1897341

Cited by 5 publications

(6 citation statements)

References 4 publications

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“…Viral infection is a recognized cause of rhabdomyolysis which often initially presents with myalgias. Similar cases of rhabdomyolysis associated with COVID-19 infection have been reported in the literature beginning in the early months of the pandemic [4][5][6][7][8][9][10][11][12][13]. Our report demonstrates a case of rhabdomyolysis with an extremely high CK value that was treated with a high flow rate of IV fluids and resolved completely with no residual kidney disease and no need for hemodialysis during treatment.…”

Section: Discussionsupporting

confidence: 82%

“…Viral infection is a recognized cause of rhabdomyolysis, which often initially presents with myalgias, as many viruses also do without concurrent rhabdomyolysis [1]. Numerous case studies have specifically reported associations between COVID-19 infection and rhabdomyolysis [4][5][6][7][8][9][10][11][12][13][14]. Thus, it is important to monitor COVID-19 patients with appropriate physical exams and labs in order to diagnose rhabdomyolysis early, initiate treatment, and mitigate downstream effects of proteinemia and myoglobinuria, such as acute kidney injury [1].…”

Section: Introductionmentioning

confidence: 99%

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Extremely Elevated Creatine Kinase in COVID-19-Associated Rhabdomyolysis

Laches,

Tillotson,

Kaufman

et al. 2023

Cureus

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Rhabdomyolysis is a condition characterized by the destruction of skeletal muscle cells with the release of myoglobin and creatine kinase into the blood. Viral infections such as influenza and Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been associated with rhabdomyolysis with varying degrees of morbidity and mortality. We present the case of a male in his early thirties who was diagnosed with rhabdomyolysis associated with coronavirus disease 2019 (COVID-19) infection who developed excessively high creatine kinase levels, peaking at 1,650,000 U/L. He was treated with IV fluids and made a complete recovery.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Extremely Elevated Creatine Kinase in COVID-19-Associated Rhabdomyolysis

Laches,

Tillotson,

Kaufman

et al. 2023

Cureus

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“…We recommend vaccinating lipin-1-deficient patients with all available vaccines, as the risk of decompensation is very high during epidemics of viral disease, and corticosteroids can make chickenpox worse. We include the vaccination against COVID-19, 22 although PAP-1 deficiency significantly suppresses SARS-CoV-2 replication 23 and this vaccine can be responsive for RM. 24 The innate immune system acts as the first line of defense against invading pathogens.…”

Section: Discussionmentioning

confidence: 99%

Systemic corticosteroids for the treatment of acute episodes of rhabdomyolysis in lipin‐1‐deficient patients

Tuchmann-Durand

Roda

Renard

et al. 2023

J of Inher Metab Disea

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Mutations in the LPIN1 gene constitute a major cause of severe rhabdomyolysis (RM). The TLR9 activation prompted us to treat patients with corticosteroids in acute conditions. In patients with LPIN1 mutations, RM and at‐risk situations that can trigger RM have been treated in a uniform manner. Since 2015, these patients have also received intravenous corticosteroids. We retrospectively compared data on hospital stays by corticosteroid‐treated patients vs. patients not treated with corticosteroids. Nineteen patients were hospitalized. The median number of admissions per patient was 21 overall and did not differ when comparing the 10 corticosteroid‐treated patients with the 9 patients not treated with corticosteroids. Four patients in the non‐corticosteroid group died during a RM (mean age at death: 5.6 years). There were no deaths in the corticosteroid group. The two groups did not differ significantly in the number of RM episodes. However, for the six patients who had RM and occasionally been treated with corticosteroids, the median number of RM episodes was significantly lower when intravenous steroids had been administered. The peak plasma creatine kinase level and the area under the curve were or tended to be higher in patients treated with corticosteroids—even after the exclusion of deceased patients or focusing on the period after 2015. The median length of stay (10 days overall) was significantly longer for corticosteroid‐treated patients but was similar after the exclusion of deceased patients. The absence of deaths and the higher severity of RM observed among corticosteroid‐treated patients could suggest that corticotherapy is associated with greater survival.

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“…Additionally, it has been well documented case reports of COVID-19 related rhabdomyolysis ( Alrubaye and Choudhary, 2020 ; Chan et al, 2020 ; Husain et al, 2020 ; Khosla et al, 2020 ; Meegada et al, 2020 ; Mukherjee et al, 2020 ; Rivas-García et al, 2020 ; Rosato et al, 2020 ; Singh et al, 2020 ; Byler et al, 2021 ; Haroun et al, 2021 ; Mah et al, 2021 ; Patel et al, 2021 ). Rhabdomyolysis is a skeletal muscle injury that can result in acute kidney injury, a life-threatening clinical complication.…”

Section: The Musculoskeletal Symptomatologymentioning

confidence: 97%

The Musculoskeletal Involvement After Mild to Moderate COVID-19 Infection

et al. 2022

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COVID-19, a disease caused by the novel coronavirus SARS-CoV-2, has been drastically affecting the daily lives of millions of people. COVID-19 is described as a multiorgan disease that affects not only the respiratory tract of infected individuals, but it has considerable effects on the musculoskeletal system, causing excessive fatigue, myalgia, arthralgia, muscle weakness and skeletal muscle damage. These symptoms can persist for months, decreasing the quality of life of numerous individuals. Curiously, most studies in the scientific literature focus on patients who were hospitalized due to SARS-CoV-2 infection and little is known about the mechanism of action of COVID-19 on skeletal muscles, especially of individuals who had the mild to moderate forms of the disease (non-hospitalized patients). In this review, we focus on the current knowledge about the musculoskeletal system in COVID-19, highlighting the lack of researches investigating the mild to moderate cases of infection and pointing out why it is essential to care for these patients. Also, we will comment about the need of more experimental data to assess the musculoskeletal manifestations on COVID-19-positive individuals.

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COVID-19 infection and severe rhabdomyolysis

Cited by 5 publications

References 4 publications

Extremely Elevated Creatine Kinase in COVID-19-Associated Rhabdomyolysis

Extremely Elevated Creatine Kinase in COVID-19-Associated Rhabdomyolysis

Systemic corticosteroids for the treatment of acute episodes of rhabdomyolysis in lipin‐1‐deficient patients

The Musculoskeletal Involvement After Mild to Moderate COVID-19 Infection

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